Communication pathways bridge local and global conformations in an IgG4 antibody

Abstract The affinity of an antibody for its antigen is primarily determined by the specific sequence and structural arrangement of the complementarity-determining regions (CDRs). Recent evidence, however, points toward a nontrivial relation between the CDR and distal sites: variations in the bindin...

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Autores principales: Thomas Tarenzi, Marta Rigoli, Raffaello Potestio
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
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Acceso en línea:https://doaj.org/article/66ff6bb769b24adb806d3721acdfc7ae
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