Blood-brain-barrier spheroids as an in vitro screening platform for brain-penetrating agents

In vitroblood-brain barrier (BBB) models are crucial tools for screening brain-penetrating compounds. Here the authors develop a self-assembling BBB spheroid model with superior performance to the standard transwell BBB model, and use their platform to identify cell-penetrating peptides that can cro...

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Autores principales:	Choi-Fong Cho, Justin M. Wolfe, Colin M. Fadzen, David Calligaris, Kalvis Hornburg, E. Antonio Chiocca, Nathalie Y. R. Agar, Bradley L. Pentelute, Sean E. Lawler
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/66ff86f13d85438c93395cad172f6fbe
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id	oai:doaj.org-article:66ff86f13d85438c93395cad172f6fbe
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spelling	oai:doaj.org-article:66ff86f13d85438c93395cad172f6fbe2021-12-02T14:42:20ZBlood-brain-barrier spheroids as an in vitro screening platform for brain-penetrating agents10.1038/ncomms156232041-1723https://doaj.org/article/66ff86f13d85438c93395cad172f6fbe2017-06-01T00:00:00Zhttps://doi.org/10.1038/ncomms15623https://doaj.org/toc/2041-1723In vitroblood-brain barrier (BBB) models are crucial tools for screening brain-penetrating compounds. Here the authors develop a self-assembling BBB spheroid model with superior performance to the standard transwell BBB model, and use their platform to identify cell-penetrating peptides that can cross the BBB.Choi-Fong ChoJustin M. WolfeColin M. FadzenDavid CalligarisKalvis HornburgE. Antonio ChioccaNathalie Y. R. AgarBradley L. PenteluteSean E. LawlerNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-14 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Choi-Fong Cho Justin M. Wolfe Colin M. Fadzen David Calligaris Kalvis Hornburg E. Antonio Chiocca Nathalie Y. R. Agar Bradley L. Pentelute Sean E. Lawler Blood-brain-barrier spheroids as an in vitro screening platform for brain-penetrating agents
description	In vitroblood-brain barrier (BBB) models are crucial tools for screening brain-penetrating compounds. Here the authors develop a self-assembling BBB spheroid model with superior performance to the standard transwell BBB model, and use their platform to identify cell-penetrating peptides that can cross the BBB.
format	article
author	Choi-Fong Cho Justin M. Wolfe Colin M. Fadzen David Calligaris Kalvis Hornburg E. Antonio Chiocca Nathalie Y. R. Agar Bradley L. Pentelute Sean E. Lawler
author_facet	Choi-Fong Cho Justin M. Wolfe Colin M. Fadzen David Calligaris Kalvis Hornburg E. Antonio Chiocca Nathalie Y. R. Agar Bradley L. Pentelute Sean E. Lawler
author_sort	Choi-Fong Cho
title	Blood-brain-barrier spheroids as an in vitro screening platform for brain-penetrating agents
title_short	Blood-brain-barrier spheroids as an in vitro screening platform for brain-penetrating agents
title_full	Blood-brain-barrier spheroids as an in vitro screening platform for brain-penetrating agents
title_fullStr	Blood-brain-barrier spheroids as an in vitro screening platform for brain-penetrating agents
title_full_unstemmed	Blood-brain-barrier spheroids as an in vitro screening platform for brain-penetrating agents
title_sort	blood-brain-barrier spheroids as an in vitro screening platform for brain-penetrating agents
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/66ff86f13d85438c93395cad172f6fbe
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Blood-brain-barrier spheroids as an in vitro screening platform for brain-penetrating agents

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