Biological correlates before esophageal cancer screening and after diagnosis

Abstract Almost 50% of the world’s esophageal cancer (EC) cases occur in China, and the impact of cancer screening has long been a controversial topic. The study was designed to evaluate the biological correlates of EC screening and subsequent diagnosis in China. Based on the national cohort of esop...

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Autores principales: Juan Zhu, Shanrui Ma, Ru Chen, Shuanghua Xie, Zhengkui Liu, Xinqing Li, Wenqiang Wei
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Publicado: Nature Portfolio 2021
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spelling oai:doaj.org-article:670132fda4ff473c896bc96db2a609152021-12-02T18:53:18ZBiological correlates before esophageal cancer screening and after diagnosis10.1038/s41598-021-96548-52045-2322https://doaj.org/article/670132fda4ff473c896bc96db2a609152021-08-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-96548-5https://doaj.org/toc/2045-2322Abstract Almost 50% of the world’s esophageal cancer (EC) cases occur in China, and the impact of cancer screening has long been a controversial topic. The study was designed to evaluate the biological correlates of EC screening and subsequent diagnosis in China. Based on the national cohort of esophageal cancer program, a prospective multicenter study in high-risk regions was conducted from 2017 to 2019. 61 participants received twice esophageal endoscopy screening and pathological biopsy successively (with a mean follow-up of 14.03 months). Box–Cox-power transformation and two-way repeated measures ANOVA were used to evaluate hormone cortisol and immunoglobulin (IgA, IgG, IgM) levels in plasma, reflecting their stress, immune function, and biological correlates before screening and after knowing the diagnosis. The median of cortisol, IgA, IgG, and IgM in pre-screening was 15.46 ug/dL, 1.86 g/L, 12.14 g/L, and 0.91 g/L, corresponding value at post-diagnosis was 15.30 ug/dL, 2.00 g/L, 12.79 g/L, and 0.94 g/L, respectively. No significant differences in biological indicators were found between normal and esophagitis and low-grade intraepithelial neoplasia before screening and after diagnosis. After normality transformation, cortisol, IgA, IgG and IgM levels were (0.25 ± 0.04) U/mL, (0.72 ± 0.13) (g/L), (2.44 ± 0.22) (g/L) and (0.98 ± 0.25) (g/L) before screening, (0.25 ± 0.05) U/mL, (0.70 ± 0.13) (g/L), (2.48 ± 0.21) (g/L) and (1.00 ± 0.25) (g/L) after diagnosis, respectively. Repeated Measures ANOVA showed that the main effects were significant on IgA levels between pre-screening and post-diagnosis (P = 0.019). No interaction effects on biological levels between pre-post screening and esophageal pathology, anxiety states (all P > 0.05). Little biological correlates were found both before screening and after diagnosis. Cortisol and IgA dropped less significantly, while IgM and IgA were increased slightly after diagnosis. Further multi-round longitudinal studies are needed to validate these results.Juan ZhuShanrui MaRu ChenShuanghua XieZhengkui LiuXinqing LiWenqiang WeiNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-8 (2021)
institution DOAJ
collection DOAJ
language EN
topic Medicine
R
Science
Q
spellingShingle Medicine
R
Science
Q
Juan Zhu
Shanrui Ma
Ru Chen
Shuanghua Xie
Zhengkui Liu
Xinqing Li
Wenqiang Wei
Biological correlates before esophageal cancer screening and after diagnosis
description Abstract Almost 50% of the world’s esophageal cancer (EC) cases occur in China, and the impact of cancer screening has long been a controversial topic. The study was designed to evaluate the biological correlates of EC screening and subsequent diagnosis in China. Based on the national cohort of esophageal cancer program, a prospective multicenter study in high-risk regions was conducted from 2017 to 2019. 61 participants received twice esophageal endoscopy screening and pathological biopsy successively (with a mean follow-up of 14.03 months). Box–Cox-power transformation and two-way repeated measures ANOVA were used to evaluate hormone cortisol and immunoglobulin (IgA, IgG, IgM) levels in plasma, reflecting their stress, immune function, and biological correlates before screening and after knowing the diagnosis. The median of cortisol, IgA, IgG, and IgM in pre-screening was 15.46 ug/dL, 1.86 g/L, 12.14 g/L, and 0.91 g/L, corresponding value at post-diagnosis was 15.30 ug/dL, 2.00 g/L, 12.79 g/L, and 0.94 g/L, respectively. No significant differences in biological indicators were found between normal and esophagitis and low-grade intraepithelial neoplasia before screening and after diagnosis. After normality transformation, cortisol, IgA, IgG and IgM levels were (0.25 ± 0.04) U/mL, (0.72 ± 0.13) (g/L), (2.44 ± 0.22) (g/L) and (0.98 ± 0.25) (g/L) before screening, (0.25 ± 0.05) U/mL, (0.70 ± 0.13) (g/L), (2.48 ± 0.21) (g/L) and (1.00 ± 0.25) (g/L) after diagnosis, respectively. Repeated Measures ANOVA showed that the main effects were significant on IgA levels between pre-screening and post-diagnosis (P = 0.019). No interaction effects on biological levels between pre-post screening and esophageal pathology, anxiety states (all P > 0.05). Little biological correlates were found both before screening and after diagnosis. Cortisol and IgA dropped less significantly, while IgM and IgA were increased slightly after diagnosis. Further multi-round longitudinal studies are needed to validate these results.
format article
author Juan Zhu
Shanrui Ma
Ru Chen
Shuanghua Xie
Zhengkui Liu
Xinqing Li
Wenqiang Wei
author_facet Juan Zhu
Shanrui Ma
Ru Chen
Shuanghua Xie
Zhengkui Liu
Xinqing Li
Wenqiang Wei
author_sort Juan Zhu
title Biological correlates before esophageal cancer screening and after diagnosis
title_short Biological correlates before esophageal cancer screening and after diagnosis
title_full Biological correlates before esophageal cancer screening and after diagnosis
title_fullStr Biological correlates before esophageal cancer screening and after diagnosis
title_full_unstemmed Biological correlates before esophageal cancer screening and after diagnosis
title_sort biological correlates before esophageal cancer screening and after diagnosis
publisher Nature Portfolio
publishDate 2021
url https://doaj.org/article/670132fda4ff473c896bc96db2a60915
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