Arrestins contribute to amyloid beta-induced cell death via modulation of autophagy and the α7nAch receptor in SH-SY5Y cells

Abstract Amyloid β-protein (Aβ) is believed to contribute to the development of Alzheimer’s disease (AD). Here we showed that Aβ25-35 rapidly caused activation of autophagy, subsequently leading to reduction of autophagy associated with cellular apoptosis. Further investigation revealed that the acc...

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Autores principales: Yi-qing Liu, Meng-qi Jia, Zhao-hong Xie, Xiao-fei Liu, Hui-Yang, Xiao-lei Zheng, Hui-qing Yuan, Jian-zhong Bi
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2017
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Acceso en línea:https://doaj.org/article/67019f06892b4c4e970964bf203f83e3
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