Finite Element Analysis on Wall Fluid Shear Stress on Cells under Oscillatory Flow

During mechanical stimulation-induced bone remodeling, interstitial fluid around microcracks may produce a flow field with gradient fluid shear stress (FSS). Osteoclast precursors can sense this gradient FSS and migrate toward the low FSS region. However, the local distribution of wall FSS on bone c...

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Autores principales:	Xiao Zhang, Yan Gao, Bo Huo
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	parallel plate flow chamber fluid shear stress finite element analysis oscillatory flow cell migration Technology T Engineering (General). Civil engineering (General) TA1-2040 Biology (General) QH301-705.5 Physics QC1-999 Chemistry QD1-999
Acceso en línea:	https://doaj.org/article/6701bc9248dd4cf2b1f7646a23662551
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id	oai:doaj.org-article:6701bc9248dd4cf2b1f7646a23662551
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spelling	oai:doaj.org-article:6701bc9248dd4cf2b1f7646a236625512021-11-11T15:06:12ZFinite Element Analysis on Wall Fluid Shear Stress on Cells under Oscillatory Flow10.3390/app1121100212076-3417https://doaj.org/article/6701bc9248dd4cf2b1f7646a236625512021-10-01T00:00:00Zhttps://www.mdpi.com/2076-3417/11/21/10021https://doaj.org/toc/2076-3417During mechanical stimulation-induced bone remodeling, interstitial fluid around microcracks may produce a flow field with gradient fluid shear stress (FSS). Osteoclast precursors can sense this gradient FSS and migrate toward the low FSS region. However, the local distribution of wall FSS on bone cells under a flow field with globally gradient FSS remains unknown. In this study, finite element models of a modified plate flow chamber with cells were constructed. The effect of oscillatory flow with different FSS levels and cell spacings or frequencies on the distribution of local wall FSS around cells was simulated by using a fluid–solid coupling method. Results showed that the polarization of wall FSS distribution in a cell decreased with the increase in cell spacing. At a low FSS level, the frequency of oscillatory flow had a minimal effect on the wall FSS distribution. At a high FSS level, the increase in flow frequency enhanced the fluctuation of local wall FSS distribution on cells. These results provide a basis for future research on the flow-induced migration of osteoclast precursors and clarify the mechanism of mechanical stimulation-induced bone resorption.Xiao ZhangYan GaoBo HuoMDPI AGarticleparallel plate flow chamberfluid shear stressfinite element analysisoscillatory flowcell migrationTechnologyTEngineering (General). Civil engineering (General)TA1-2040Biology (General)QH301-705.5PhysicsQC1-999ChemistryQD1-999ENApplied Sciences, Vol 11, Iss 10021, p 10021 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	parallel plate flow chamber fluid shear stress finite element analysis oscillatory flow cell migration Technology T Engineering (General). Civil engineering (General) TA1-2040 Biology (General) QH301-705.5 Physics QC1-999 Chemistry QD1-999
spellingShingle	parallel plate flow chamber fluid shear stress finite element analysis oscillatory flow cell migration Technology T Engineering (General). Civil engineering (General) TA1-2040 Biology (General) QH301-705.5 Physics QC1-999 Chemistry QD1-999 Xiao Zhang Yan Gao Bo Huo Finite Element Analysis on Wall Fluid Shear Stress on Cells under Oscillatory Flow
description	During mechanical stimulation-induced bone remodeling, interstitial fluid around microcracks may produce a flow field with gradient fluid shear stress (FSS). Osteoclast precursors can sense this gradient FSS and migrate toward the low FSS region. However, the local distribution of wall FSS on bone cells under a flow field with globally gradient FSS remains unknown. In this study, finite element models of a modified plate flow chamber with cells were constructed. The effect of oscillatory flow with different FSS levels and cell spacings or frequencies on the distribution of local wall FSS around cells was simulated by using a fluid–solid coupling method. Results showed that the polarization of wall FSS distribution in a cell decreased with the increase in cell spacing. At a low FSS level, the frequency of oscillatory flow had a minimal effect on the wall FSS distribution. At a high FSS level, the increase in flow frequency enhanced the fluctuation of local wall FSS distribution on cells. These results provide a basis for future research on the flow-induced migration of osteoclast precursors and clarify the mechanism of mechanical stimulation-induced bone resorption.
format	article
author	Xiao Zhang Yan Gao Bo Huo
author_facet	Xiao Zhang Yan Gao Bo Huo
author_sort	Xiao Zhang
title	Finite Element Analysis on Wall Fluid Shear Stress on Cells under Oscillatory Flow
title_short	Finite Element Analysis on Wall Fluid Shear Stress on Cells under Oscillatory Flow
title_full	Finite Element Analysis on Wall Fluid Shear Stress on Cells under Oscillatory Flow
title_fullStr	Finite Element Analysis on Wall Fluid Shear Stress on Cells under Oscillatory Flow
title_full_unstemmed	Finite Element Analysis on Wall Fluid Shear Stress on Cells under Oscillatory Flow
title_sort	finite element analysis on wall fluid shear stress on cells under oscillatory flow
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/6701bc9248dd4cf2b1f7646a23662551
work_keys_str_mv	AT xiaozhang finiteelementanalysisonwallfluidshearstressoncellsunderoscillatoryflow AT yangao finiteelementanalysisonwallfluidshearstressoncellsunderoscillatoryflow AT bohuo finiteelementanalysisonwallfluidshearstressoncellsunderoscillatoryflow
_version_	1718437145060835328

Finite Element Analysis on Wall Fluid Shear Stress on Cells under Oscillatory Flow

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