Protrudin and PDZD8 contribute to neuronal integrity by promoting lipid extraction required for endosome maturation

Interorganelle membrane contact sites between the endoplasmic reticulum and the endolysosome. Here, the authors show that ER-endolysosome membrane contact sites are promoted by the proteins protrudin and PDZD8 and may contribute to lipid extraction at these contact sites.

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Autores principales:	Michiko Shirane, Mariko Wada, Keiko Morita, Nahoki Hayashi, Reina Kunimatsu, Yuki Matsumoto, Fumiko Matsuzaki, Hirokazu Nakatsumi, Keisuke Ohta, Yasushi Tamura, Keiichi I. Nakayama
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/670432a918664d32a912916b09eded29
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spelling	oai:doaj.org-article:670432a918664d32a912916b09eded292021-12-02T19:12:33ZProtrudin and PDZD8 contribute to neuronal integrity by promoting lipid extraction required for endosome maturation10.1038/s41467-020-18413-92041-1723https://doaj.org/article/670432a918664d32a912916b09eded292020-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-18413-9https://doaj.org/toc/2041-1723Interorganelle membrane contact sites between the endoplasmic reticulum and the endolysosome. Here, the authors show that ER-endolysosome membrane contact sites are promoted by the proteins protrudin and PDZD8 and may contribute to lipid extraction at these contact sites.Michiko ShiraneMariko WadaKeiko MoritaNahoki HayashiReina KunimatsuYuki MatsumotoFumiko MatsuzakiHirokazu NakatsumiKeisuke OhtaYasushi TamuraKeiichi I. NakayamaNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-19 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Michiko Shirane Mariko Wada Keiko Morita Nahoki Hayashi Reina Kunimatsu Yuki Matsumoto Fumiko Matsuzaki Hirokazu Nakatsumi Keisuke Ohta Yasushi Tamura Keiichi I. Nakayama Protrudin and PDZD8 contribute to neuronal integrity by promoting lipid extraction required for endosome maturation
description	Interorganelle membrane contact sites between the endoplasmic reticulum and the endolysosome. Here, the authors show that ER-endolysosome membrane contact sites are promoted by the proteins protrudin and PDZD8 and may contribute to lipid extraction at these contact sites.
format	article
author	Michiko Shirane Mariko Wada Keiko Morita Nahoki Hayashi Reina Kunimatsu Yuki Matsumoto Fumiko Matsuzaki Hirokazu Nakatsumi Keisuke Ohta Yasushi Tamura Keiichi I. Nakayama
author_facet	Michiko Shirane Mariko Wada Keiko Morita Nahoki Hayashi Reina Kunimatsu Yuki Matsumoto Fumiko Matsuzaki Hirokazu Nakatsumi Keisuke Ohta Yasushi Tamura Keiichi I. Nakayama
author_sort	Michiko Shirane
title	Protrudin and PDZD8 contribute to neuronal integrity by promoting lipid extraction required for endosome maturation
title_short	Protrudin and PDZD8 contribute to neuronal integrity by promoting lipid extraction required for endosome maturation
title_full	Protrudin and PDZD8 contribute to neuronal integrity by promoting lipid extraction required for endosome maturation
title_fullStr	Protrudin and PDZD8 contribute to neuronal integrity by promoting lipid extraction required for endosome maturation
title_full_unstemmed	Protrudin and PDZD8 contribute to neuronal integrity by promoting lipid extraction required for endosome maturation
title_sort	protrudin and pdzd8 contribute to neuronal integrity by promoting lipid extraction required for endosome maturation
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/670432a918664d32a912916b09eded29
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Protrudin and PDZD8 contribute to neuronal integrity by promoting lipid extraction required for endosome maturation

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