Comparative analysis of HLA II allele and genotype frequency distribution in patients with type 1 diabetes mellitus and autoimmune thyroiditis

Aim. To compare HLA II allele and genotype frequency distribution in type 1 diabetes mellitus (T1DM) and autoimmune thyroiditis (AIT) with that in isolated T1DM. Materials and Methods. A total of 92 T1DM patients were subdivided into two groups. The first group comprised 54 patients with establis...

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Autores principales:	Ekaterina Alexandrovna Repina, Tatiana Mikhailovna Atamanova, Yana Stanislavovna Zvereva, Yulia Vladimirovna Tishina, Sergey Alexandrovich Prokof'ev
Formato:	article
Lenguaje:	EN RU
Publicado:	Endocrinology Research Centre 2013
Materias:	type 1 diabetes mellitus autoimmune thyroiditis hla ii allele genotype Nutritional diseases. Deficiency diseases RC620-627
Acceso en línea:	https://doaj.org/article/67052df2df23436ca12c5ce56867da7d
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spelling	oai:doaj.org-article:67052df2df23436ca12c5ce56867da7d2021-11-14T09:00:18ZComparative analysis of HLA II allele and genotype frequency distribution in patients with type 1 diabetes mellitus and autoimmune thyroiditis2072-03512072-037810.14341/DM2013423-27https://doaj.org/article/67052df2df23436ca12c5ce56867da7d2013-12-01T00:00:00Zhttps://www.dia-endojournals.ru/jour/article/view/6268https://doaj.org/toc/2072-0351https://doaj.org/toc/2072-0378Aim. To compare HLA II allele and genotype frequency distribution in type 1 diabetes mellitus (T1DM) and autoimmune thyroiditis (AIT) with that in isolated T1DM. Materials and Methods. A total of 92 T1DM patients were subdivided into two groups. The first group comprised 54 patients with established AIT comorbidity or elevation of anti-thyroid autoantibodies (ATA). Patients with isolated T1DM (ATA-negative) formed the second group. HLA-genotyping was performed by multiprimer PCR set for the three following genes: DRB1, DQA1 and DQВ1. Results. Prevalence of alleles DRB101, 03(017), 04, 07, *11 and genotypes 01/03, 01/04, 03/04 tends to be higher among patients with AIT comorbidity. The comorbidity group was also characterized by the trend towards higher prevalence of ?marker/marker? and ?marker/non-marker? combinations favouring the former variant. Conversely, ATA-negative patients exhibited trend for higher prevalence of ?non-marker/non-marker? combination. Conclusion. Statistically insignificant difference between HLA II alleles and genotypes in the two studied groups suggests that primary genetic factors are common in these two diseases. Plausibly, genes other than DRB1, DQA1 and DQВ1 determine the localization of the autoimmune process.Ekaterina Alexandrovna RepinaTatiana Mikhailovna AtamanovaYana Stanislavovna ZverevaYulia Vladimirovna TishinaSergey Alexandrovich Prokof'evEndocrinology Research Centrearticletype 1 diabetes mellitusautoimmune thyroiditishla iiallelegenotypeNutritional diseases. Deficiency diseasesRC620-627ENRUСахарный диабет, Vol 16, Iss 4, Pp 23-27 (2013)
institution	DOAJ
collection	DOAJ
language	EN RU
topic	type 1 diabetes mellitus autoimmune thyroiditis hla ii allele genotype Nutritional diseases. Deficiency diseases RC620-627
spellingShingle	type 1 diabetes mellitus autoimmune thyroiditis hla ii allele genotype Nutritional diseases. Deficiency diseases RC620-627 Ekaterina Alexandrovna Repina Tatiana Mikhailovna Atamanova Yana Stanislavovna Zvereva Yulia Vladimirovna Tishina Sergey Alexandrovich Prokof'ev Comparative analysis of HLA II allele and genotype frequency distribution in patients with type 1 diabetes mellitus and autoimmune thyroiditis
description	Aim. To compare HLA II allele and genotype frequency distribution in type 1 diabetes mellitus (T1DM) and autoimmune thyroiditis (AIT) with that in isolated T1DM. Materials and Methods. A total of 92 T1DM patients were subdivided into two groups. The first group comprised 54 patients with established AIT comorbidity or elevation of anti-thyroid autoantibodies (ATA). Patients with isolated T1DM (ATA-negative) formed the second group. HLA-genotyping was performed by multiprimer PCR set for the three following genes: DRB1, DQA1 and DQВ1. Results. Prevalence of alleles DRB101, 03(017), 04, 07, *11 and genotypes 01/03, 01/04, 03/04 tends to be higher among patients with AIT comorbidity. The comorbidity group was also characterized by the trend towards higher prevalence of ?marker/marker? and ?marker/non-marker? combinations favouring the former variant. Conversely, ATA-negative patients exhibited trend for higher prevalence of ?non-marker/non-marker? combination. Conclusion. Statistically insignificant difference between HLA II alleles and genotypes in the two studied groups suggests that primary genetic factors are common in these two diseases. Plausibly, genes other than DRB1, DQA1 and DQВ1 determine the localization of the autoimmune process.
format	article
author	Ekaterina Alexandrovna Repina Tatiana Mikhailovna Atamanova Yana Stanislavovna Zvereva Yulia Vladimirovna Tishina Sergey Alexandrovich Prokof'ev
author_facet	Ekaterina Alexandrovna Repina Tatiana Mikhailovna Atamanova Yana Stanislavovna Zvereva Yulia Vladimirovna Tishina Sergey Alexandrovich Prokof'ev
author_sort	Ekaterina Alexandrovna Repina
title	Comparative analysis of HLA II allele and genotype frequency distribution in patients with type 1 diabetes mellitus and autoimmune thyroiditis
title_short	Comparative analysis of HLA II allele and genotype frequency distribution in patients with type 1 diabetes mellitus and autoimmune thyroiditis
title_full	Comparative analysis of HLA II allele and genotype frequency distribution in patients with type 1 diabetes mellitus and autoimmune thyroiditis
title_fullStr	Comparative analysis of HLA II allele and genotype frequency distribution in patients with type 1 diabetes mellitus and autoimmune thyroiditis
title_full_unstemmed	Comparative analysis of HLA II allele and genotype frequency distribution in patients with type 1 diabetes mellitus and autoimmune thyroiditis
title_sort	comparative analysis of hla ii allele and genotype frequency distribution in patients with type 1 diabetes mellitus and autoimmune thyroiditis
publisher	Endocrinology Research Centre
publishDate	2013
url	https://doaj.org/article/67052df2df23436ca12c5ce56867da7d
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_version_	1718429584042491904

Comparative analysis of HLA II allele and genotype frequency distribution in patients with type 1 diabetes mellitus and autoimmune thyroiditis

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