Childhood overeating is associated with adverse cardiometabolic and inflammatory profiles in adolescence

Abstract Childhood eating behaviour contributes to the rise of obesity and related noncommunicable disease worldwide. However, we lack a deep understanding of biochemical alterations that can arise from aberrant eating behaviour. In this study, we prospectively associate longitudinal trajectories of...

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Autores principales:	Christopher Hübel, Moritz Herle, Diana L. Santos Ferreira, Mohamed Abdulkadir, Rachel Bryant-Waugh, Ruth J. F. Loos, Cynthia M. Bulik, Deborah A. Lawlor, Nadia Micali
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/6705bdbbd2264bb699537ef169a71886
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spelling	oai:doaj.org-article:6705bdbbd2264bb699537ef169a718862021-12-02T17:41:05ZChildhood overeating is associated with adverse cardiometabolic and inflammatory profiles in adolescence10.1038/s41598-021-90644-22045-2322https://doaj.org/article/6705bdbbd2264bb699537ef169a718862021-06-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-90644-2https://doaj.org/toc/2045-2322Abstract Childhood eating behaviour contributes to the rise of obesity and related noncommunicable disease worldwide. However, we lack a deep understanding of biochemical alterations that can arise from aberrant eating behaviour. In this study, we prospectively associate longitudinal trajectories of childhood overeating, undereating, and fussy eating with metabolic markers at age 16 years to explore adolescent metabolic alterations related to specific eating patterns in the first 10 years of life. Data are from the Avon Longitudinal Study of Parents and Children (n = 3104). We measure 158 metabolic markers with a high-throughput (1H) NMR metabolomics platform. Increasing childhood overeating is prospectively associated with an adverse cardiometabolic profile (i.e., hyperlipidemia, hypercholesterolemia, hyperlipoproteinemia) in adolescence; whereas undereating and fussy eating are associated with lower concentrations of the amino acids glutamine and valine, suggesting a potential lack of micronutrients. Here, we show associations between early behavioural indicators of eating and metabolic markers.Christopher HübelMoritz HerleDiana L. Santos FerreiraMohamed AbdulkadirRachel Bryant-WaughRuth J. F. LoosCynthia M. BulikDeborah A. LawlorNadia MicaliNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-15 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Christopher Hübel Moritz Herle Diana L. Santos Ferreira Mohamed Abdulkadir Rachel Bryant-Waugh Ruth J. F. Loos Cynthia M. Bulik Deborah A. Lawlor Nadia Micali Childhood overeating is associated with adverse cardiometabolic and inflammatory profiles in adolescence
description	Abstract Childhood eating behaviour contributes to the rise of obesity and related noncommunicable disease worldwide. However, we lack a deep understanding of biochemical alterations that can arise from aberrant eating behaviour. In this study, we prospectively associate longitudinal trajectories of childhood overeating, undereating, and fussy eating with metabolic markers at age 16 years to explore adolescent metabolic alterations related to specific eating patterns in the first 10 years of life. Data are from the Avon Longitudinal Study of Parents and Children (n = 3104). We measure 158 metabolic markers with a high-throughput (1H) NMR metabolomics platform. Increasing childhood overeating is prospectively associated with an adverse cardiometabolic profile (i.e., hyperlipidemia, hypercholesterolemia, hyperlipoproteinemia) in adolescence; whereas undereating and fussy eating are associated with lower concentrations of the amino acids glutamine and valine, suggesting a potential lack of micronutrients. Here, we show associations between early behavioural indicators of eating and metabolic markers.
format	article
author	Christopher Hübel Moritz Herle Diana L. Santos Ferreira Mohamed Abdulkadir Rachel Bryant-Waugh Ruth J. F. Loos Cynthia M. Bulik Deborah A. Lawlor Nadia Micali
author_facet	Christopher Hübel Moritz Herle Diana L. Santos Ferreira Mohamed Abdulkadir Rachel Bryant-Waugh Ruth J. F. Loos Cynthia M. Bulik Deborah A. Lawlor Nadia Micali
author_sort	Christopher Hübel
title	Childhood overeating is associated with adverse cardiometabolic and inflammatory profiles in adolescence
title_short	Childhood overeating is associated with adverse cardiometabolic and inflammatory profiles in adolescence
title_full	Childhood overeating is associated with adverse cardiometabolic and inflammatory profiles in adolescence
title_fullStr	Childhood overeating is associated with adverse cardiometabolic and inflammatory profiles in adolescence
title_full_unstemmed	Childhood overeating is associated with adverse cardiometabolic and inflammatory profiles in adolescence
title_sort	childhood overeating is associated with adverse cardiometabolic and inflammatory profiles in adolescence
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/6705bdbbd2264bb699537ef169a71886
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Childhood overeating is associated with adverse cardiometabolic and inflammatory profiles in adolescence

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