Oscillatory protein expression dynamics endows stem cells with robust differentiation potential.

The lack of understanding of stem cell differentiation and proliferation is a fundamental problem in developmental biology. Although gene regulatory networks (GRNs) for stem cell differentiation have been partially identified, the nature of differentiation dynamics and their regulation leading to ro...

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Autores principales:	Narito Suzuki, Chikara Furusawa, Kunihiko Kaneko
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2011
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/67090293bcdc4b7bab31b6a5117ce2a9
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spelling	oai:doaj.org-article:67090293bcdc4b7bab31b6a5117ce2a92021-11-18T07:35:01ZOscillatory protein expression dynamics endows stem cells with robust differentiation potential.1932-620310.1371/journal.pone.0027232https://doaj.org/article/67090293bcdc4b7bab31b6a5117ce2a92011-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/22073296/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203The lack of understanding of stem cell differentiation and proliferation is a fundamental problem in developmental biology. Although gene regulatory networks (GRNs) for stem cell differentiation have been partially identified, the nature of differentiation dynamics and their regulation leading to robust development remain unclear. Herein, using a dynamical system modeling cell approach, we performed simulations of the developmental process using all possible GRNs with a few genes, and screened GRNs that could generate cell type diversity through cell-cell interactions. We found that model stem cells that both proliferated and differentiated always exhibited oscillatory expression dynamics, and the differentiation frequency of such stem cells was regulated, resulting in a robust number distribution. Moreover, we uncovered the common regulatory motifs for stem cell differentiation, in which a combination of regulatory motifs that generated oscillatory expression dynamics and stabilized distinct cellular states played an essential role. These findings may explain the recently observed heterogeneity and dynamic equilibrium in cellular states of stem cells, and can be used to predict regulatory networks responsible for differentiation in stem cell systems.Narito SuzukiChikara FurusawaKunihiko KanekoPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 6, Iss 11, p e27232 (2011)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Narito Suzuki Chikara Furusawa Kunihiko Kaneko Oscillatory protein expression dynamics endows stem cells with robust differentiation potential.
description	The lack of understanding of stem cell differentiation and proliferation is a fundamental problem in developmental biology. Although gene regulatory networks (GRNs) for stem cell differentiation have been partially identified, the nature of differentiation dynamics and their regulation leading to robust development remain unclear. Herein, using a dynamical system modeling cell approach, we performed simulations of the developmental process using all possible GRNs with a few genes, and screened GRNs that could generate cell type diversity through cell-cell interactions. We found that model stem cells that both proliferated and differentiated always exhibited oscillatory expression dynamics, and the differentiation frequency of such stem cells was regulated, resulting in a robust number distribution. Moreover, we uncovered the common regulatory motifs for stem cell differentiation, in which a combination of regulatory motifs that generated oscillatory expression dynamics and stabilized distinct cellular states played an essential role. These findings may explain the recently observed heterogeneity and dynamic equilibrium in cellular states of stem cells, and can be used to predict regulatory networks responsible for differentiation in stem cell systems.
format	article
author	Narito Suzuki Chikara Furusawa Kunihiko Kaneko
author_facet	Narito Suzuki Chikara Furusawa Kunihiko Kaneko
author_sort	Narito Suzuki
title	Oscillatory protein expression dynamics endows stem cells with robust differentiation potential.
title_short	Oscillatory protein expression dynamics endows stem cells with robust differentiation potential.
title_full	Oscillatory protein expression dynamics endows stem cells with robust differentiation potential.
title_fullStr	Oscillatory protein expression dynamics endows stem cells with robust differentiation potential.
title_full_unstemmed	Oscillatory protein expression dynamics endows stem cells with robust differentiation potential.
title_sort	oscillatory protein expression dynamics endows stem cells with robust differentiation potential.
publisher	Public Library of Science (PLoS)
publishDate	2011
url	https://doaj.org/article/67090293bcdc4b7bab31b6a5117ce2a9
work_keys_str_mv	AT naritosuzuki oscillatoryproteinexpressiondynamicsendowsstemcellswithrobustdifferentiationpotential AT chikarafurusawa oscillatoryproteinexpressiondynamicsendowsstemcellswithrobustdifferentiationpotential AT kunihikokaneko oscillatoryproteinexpressiondynamicsendowsstemcellswithrobustdifferentiationpotential
_version_	1718423225589825536

Oscillatory protein expression dynamics endows stem cells with robust differentiation potential.

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