BRG1 attenuates colonic inflammation and tumorigenesis through autophagy-dependent oxidative stress sequestration

Dysfunctional autophagy induces inflammation that contributes to tumorigenesis. Here, the authors show that loss of BRG1 impairs autophagy and enhances reactive oxygen species production to disrupt intestinal barrier integrity, leading to spontaneous colitis and subsequent colorectal cancer developm...

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Autores principales:	Min Liu, Tongyu Sun, Ni Li, Junjie Peng, Da Fu, Wei Li, Li Li, Wei-Qiang Gao
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/670a91c070094d66a9b1c64d04f3c4c2
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spelling	oai:doaj.org-article:670a91c070094d66a9b1c64d04f3c4c22021-12-02T15:35:15ZBRG1 attenuates colonic inflammation and tumorigenesis through autophagy-dependent oxidative stress sequestration10.1038/s41467-019-12573-z2041-1723https://doaj.org/article/670a91c070094d66a9b1c64d04f3c4c22019-10-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-12573-zhttps://doaj.org/toc/2041-1723Dysfunctional autophagy induces inflammation that contributes to tumorigenesis. Here, the authors show that loss of BRG1 impairs autophagy and enhances reactive oxygen species production to disrupt intestinal barrier integrity, leading to spontaneous colitis and subsequent colorectal cancer development.Min LiuTongyu SunNi LiJunjie PengDa FuWei LiLi LiWei-Qiang GaoNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-15 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Min Liu Tongyu Sun Ni Li Junjie Peng Da Fu Wei Li Li Li Wei-Qiang Gao BRG1 attenuates colonic inflammation and tumorigenesis through autophagy-dependent oxidative stress sequestration
description	Dysfunctional autophagy induces inflammation that contributes to tumorigenesis. Here, the authors show that loss of BRG1 impairs autophagy and enhances reactive oxygen species production to disrupt intestinal barrier integrity, leading to spontaneous colitis and subsequent colorectal cancer development.
format	article
author	Min Liu Tongyu Sun Ni Li Junjie Peng Da Fu Wei Li Li Li Wei-Qiang Gao
author_facet	Min Liu Tongyu Sun Ni Li Junjie Peng Da Fu Wei Li Li Li Wei-Qiang Gao
author_sort	Min Liu
title	BRG1 attenuates colonic inflammation and tumorigenesis through autophagy-dependent oxidative stress sequestration
title_short	BRG1 attenuates colonic inflammation and tumorigenesis through autophagy-dependent oxidative stress sequestration
title_full	BRG1 attenuates colonic inflammation and tumorigenesis through autophagy-dependent oxidative stress sequestration
title_fullStr	BRG1 attenuates colonic inflammation and tumorigenesis through autophagy-dependent oxidative stress sequestration
title_full_unstemmed	BRG1 attenuates colonic inflammation and tumorigenesis through autophagy-dependent oxidative stress sequestration
title_sort	brg1 attenuates colonic inflammation and tumorigenesis through autophagy-dependent oxidative stress sequestration
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/670a91c070094d66a9b1c64d04f3c4c2
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BRG1 attenuates colonic inflammation and tumorigenesis through autophagy-dependent oxidative stress sequestration

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