Massively parallel reporter assays of melanoma risk variants identify MX2 as a gene promoting melanoma
There are more than 20 known melanoma susceptibility genes. Here, using a massively parallel reporter assay, the authors identify risk-associated variants that alter gene transcription, and demonstrate that expression of one such gene, MX2, leads to the promotion of melanoma in a zebrafish model.
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Nature Portfolio
2020
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oai:doaj.org-article:670b26b5d219499083d912a34bb1bf002021-12-02T15:56:54ZMassively parallel reporter assays of melanoma risk variants identify MX2 as a gene promoting melanoma10.1038/s41467-020-16590-12041-1723https://doaj.org/article/670b26b5d219499083d912a34bb1bf002020-06-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-16590-1https://doaj.org/toc/2041-1723There are more than 20 known melanoma susceptibility genes. Here, using a massively parallel reporter assay, the authors identify risk-associated variants that alter gene transcription, and demonstrate that expression of one such gene, MX2, leads to the promotion of melanoma in a zebrafish model.Jiyeon ChoiTongwu ZhangAndrew VuJulien AblainMatthew M. MakowskiLeandro M. ColliMai XuRebecca C. HennesseyJinhu YinHarriet RothschildCathrin GräweMichael A. KovacsKaren M. FunderburkMyriam BrossardJohn TaylorBogdan PasaniucRaj ChariStephen J. ChanockClive J. HoggartFlorence DemenaisJennifer H. BarrettMatthew H. LawMark M. IlesKai YuMichiel VermeulenLeonard I. ZonKevin M. BrownNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-16 (2020) |
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DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
Science Q |
| spellingShingle |
Science Q Jiyeon Choi Tongwu Zhang Andrew Vu Julien Ablain Matthew M. Makowski Leandro M. Colli Mai Xu Rebecca C. Hennessey Jinhu Yin Harriet Rothschild Cathrin Gräwe Michael A. Kovacs Karen M. Funderburk Myriam Brossard John Taylor Bogdan Pasaniuc Raj Chari Stephen J. Chanock Clive J. Hoggart Florence Demenais Jennifer H. Barrett Matthew H. Law Mark M. Iles Kai Yu Michiel Vermeulen Leonard I. Zon Kevin M. Brown Massively parallel reporter assays of melanoma risk variants identify MX2 as a gene promoting melanoma |
| description |
There are more than 20 known melanoma susceptibility genes. Here, using a massively parallel reporter assay, the authors identify risk-associated variants that alter gene transcription, and demonstrate that expression of one such gene, MX2, leads to the promotion of melanoma in a zebrafish model. |
| format |
article |
| author |
Jiyeon Choi Tongwu Zhang Andrew Vu Julien Ablain Matthew M. Makowski Leandro M. Colli Mai Xu Rebecca C. Hennessey Jinhu Yin Harriet Rothschild Cathrin Gräwe Michael A. Kovacs Karen M. Funderburk Myriam Brossard John Taylor Bogdan Pasaniuc Raj Chari Stephen J. Chanock Clive J. Hoggart Florence Demenais Jennifer H. Barrett Matthew H. Law Mark M. Iles Kai Yu Michiel Vermeulen Leonard I. Zon Kevin M. Brown |
| author_facet |
Jiyeon Choi Tongwu Zhang Andrew Vu Julien Ablain Matthew M. Makowski Leandro M. Colli Mai Xu Rebecca C. Hennessey Jinhu Yin Harriet Rothschild Cathrin Gräwe Michael A. Kovacs Karen M. Funderburk Myriam Brossard John Taylor Bogdan Pasaniuc Raj Chari Stephen J. Chanock Clive J. Hoggart Florence Demenais Jennifer H. Barrett Matthew H. Law Mark M. Iles Kai Yu Michiel Vermeulen Leonard I. Zon Kevin M. Brown |
| author_sort |
Jiyeon Choi |
| title |
Massively parallel reporter assays of melanoma risk variants identify MX2 as a gene promoting melanoma |
| title_short |
Massively parallel reporter assays of melanoma risk variants identify MX2 as a gene promoting melanoma |
| title_full |
Massively parallel reporter assays of melanoma risk variants identify MX2 as a gene promoting melanoma |
| title_fullStr |
Massively parallel reporter assays of melanoma risk variants identify MX2 as a gene promoting melanoma |
| title_full_unstemmed |
Massively parallel reporter assays of melanoma risk variants identify MX2 as a gene promoting melanoma |
| title_sort |
massively parallel reporter assays of melanoma risk variants identify mx2 as a gene promoting melanoma |
| publisher |
Nature Portfolio |
| publishDate |
2020 |
| url |
https://doaj.org/article/670b26b5d219499083d912a34bb1bf00 |
| work_keys_str_mv |
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