Durable remission of renal cell carcinoma in conjuncture with graft versus host disease following allogeneic stem cell transplantation and donor lymphocyte infusion: rule or exception?

Allogeneic stem cell transplantation (alloSCT) followed by donor lymphocyte infusion (DLI) can be applied as immunotherapeutic intervention to treat malignant diseases. Here, we describe a patient with progressive metastatic clear cell renal cell carcinoma (RCC) who was treated with T cell depleted...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Cornelis A M van Bergen, Elisabeth M E Verdegaal, M Wilhelmina Honders, Conny Hoogstraten, A Q M Jeanne Steijn-van Tol, Linda de Quartel, Joan de Jong, Maaike Meyering, J H Frederik Falkenburg, Marieke Griffioen, Susanne Osanto
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2014
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/670c2aedb5b04ebea05014475c2038e6
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:670c2aedb5b04ebea05014475c2038e6
record_format	dspace
spelling	oai:doaj.org-article:670c2aedb5b04ebea05014475c2038e62021-11-18T08:37:42ZDurable remission of renal cell carcinoma in conjuncture with graft versus host disease following allogeneic stem cell transplantation and donor lymphocyte infusion: rule or exception?1932-620310.1371/journal.pone.0085198https://doaj.org/article/670c2aedb5b04ebea05014475c2038e62014-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24454818/?tool=EBIhttps://doaj.org/toc/1932-6203Allogeneic stem cell transplantation (alloSCT) followed by donor lymphocyte infusion (DLI) can be applied as immunotherapeutic intervention to treat malignant diseases. Here, we describe a patient with progressive metastatic clear cell renal cell carcinoma (RCC) who was treated with T cell depleted non-myeloablative alloSCT and DLI resulting in disease regression accompanied by extensive graft versus host disease (GVHD). We characterized the specificity of this immune response, and detected a dominant T cell population recognizing a novel minor histocompatibility antigen (MiHA) designated LB-FUCA2-1V. T cells specific for LB-FUCA2-1V were shown to recognize RCC cell lines, supporting a dominant role in the graft versus tumor (GVT) reaction. However, coinciding with the gradual disappearance of chronic GVHD, the anti-tumor effect declined and 3 years after alloSCT the metastases became progressive again. To re-initiate the GVT reaction, escalating doses of DLI were given, but no immune response could be induced and the patient died of progressive disease 8.5 years after alloSCT. Gene expression studies illustrated that only a minimal number of genes shared expression between RCC and professional antigen presenting cells but were not expressed by non-malignant healthy tissues, indicating that in patients suffering from RCC, GVT reactivity after alloSCT may be unavoidably linked to GVHD.Cornelis A M van BergenElisabeth M E VerdegaalM Wilhelmina HondersConny HoogstratenA Q M Jeanne Steijn-van TolLinda de QuartelJoan de JongMaaike MeyeringJ H Frederik FalkenburgMarieke GriffioenSusanne OsantoPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 9, Iss 1, p e85198 (2014)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Cornelis A M van Bergen Elisabeth M E Verdegaal M Wilhelmina Honders Conny Hoogstraten A Q M Jeanne Steijn-van Tol Linda de Quartel Joan de Jong Maaike Meyering J H Frederik Falkenburg Marieke Griffioen Susanne Osanto Durable remission of renal cell carcinoma in conjuncture with graft versus host disease following allogeneic stem cell transplantation and donor lymphocyte infusion: rule or exception?
description	Allogeneic stem cell transplantation (alloSCT) followed by donor lymphocyte infusion (DLI) can be applied as immunotherapeutic intervention to treat malignant diseases. Here, we describe a patient with progressive metastatic clear cell renal cell carcinoma (RCC) who was treated with T cell depleted non-myeloablative alloSCT and DLI resulting in disease regression accompanied by extensive graft versus host disease (GVHD). We characterized the specificity of this immune response, and detected a dominant T cell population recognizing a novel minor histocompatibility antigen (MiHA) designated LB-FUCA2-1V. T cells specific for LB-FUCA2-1V were shown to recognize RCC cell lines, supporting a dominant role in the graft versus tumor (GVT) reaction. However, coinciding with the gradual disappearance of chronic GVHD, the anti-tumor effect declined and 3 years after alloSCT the metastases became progressive again. To re-initiate the GVT reaction, escalating doses of DLI were given, but no immune response could be induced and the patient died of progressive disease 8.5 years after alloSCT. Gene expression studies illustrated that only a minimal number of genes shared expression between RCC and professional antigen presenting cells but were not expressed by non-malignant healthy tissues, indicating that in patients suffering from RCC, GVT reactivity after alloSCT may be unavoidably linked to GVHD.
format	article
author	Cornelis A M van Bergen Elisabeth M E Verdegaal M Wilhelmina Honders Conny Hoogstraten A Q M Jeanne Steijn-van Tol Linda de Quartel Joan de Jong Maaike Meyering J H Frederik Falkenburg Marieke Griffioen Susanne Osanto
author_facet	Cornelis A M van Bergen Elisabeth M E Verdegaal M Wilhelmina Honders Conny Hoogstraten A Q M Jeanne Steijn-van Tol Linda de Quartel Joan de Jong Maaike Meyering J H Frederik Falkenburg Marieke Griffioen Susanne Osanto
author_sort	Cornelis A M van Bergen
title	Durable remission of renal cell carcinoma in conjuncture with graft versus host disease following allogeneic stem cell transplantation and donor lymphocyte infusion: rule or exception?
title_short	Durable remission of renal cell carcinoma in conjuncture with graft versus host disease following allogeneic stem cell transplantation and donor lymphocyte infusion: rule or exception?
title_full	Durable remission of renal cell carcinoma in conjuncture with graft versus host disease following allogeneic stem cell transplantation and donor lymphocyte infusion: rule or exception?
title_fullStr	Durable remission of renal cell carcinoma in conjuncture with graft versus host disease following allogeneic stem cell transplantation and donor lymphocyte infusion: rule or exception?
title_full_unstemmed	Durable remission of renal cell carcinoma in conjuncture with graft versus host disease following allogeneic stem cell transplantation and donor lymphocyte infusion: rule or exception?
title_sort	durable remission of renal cell carcinoma in conjuncture with graft versus host disease following allogeneic stem cell transplantation and donor lymphocyte infusion: rule or exception?
publisher	Public Library of Science (PLoS)
publishDate	2014
url	https://doaj.org/article/670c2aedb5b04ebea05014475c2038e6
work_keys_str_mv	AT cornelisamvanbergen durableremissionofrenalcellcarcinomainconjuncturewithgraftversushostdiseasefollowingallogeneicstemcelltransplantationanddonorlymphocyteinfusionruleorexception AT elisabethmeverdegaal durableremissionofrenalcellcarcinomainconjuncturewithgraftversushostdiseasefollowingallogeneicstemcelltransplantationanddonorlymphocyteinfusionruleorexception AT mwilhelminahonders durableremissionofrenalcellcarcinomainconjuncturewithgraftversushostdiseasefollowingallogeneicstemcelltransplantationanddonorlymphocyteinfusionruleorexception AT connyhoogstraten durableremissionofrenalcellcarcinomainconjuncturewithgraftversushostdiseasefollowingallogeneicstemcelltransplantationanddonorlymphocyteinfusionruleorexception AT aqmjeannesteijnvantol durableremissionofrenalcellcarcinomainconjuncturewithgraftversushostdiseasefollowingallogeneicstemcelltransplantationanddonorlymphocyteinfusionruleorexception AT lindadequartel durableremissionofrenalcellcarcinomainconjuncturewithgraftversushostdiseasefollowingallogeneicstemcelltransplantationanddonorlymphocyteinfusionruleorexception AT joandejong durableremissionofrenalcellcarcinomainconjuncturewithgraftversushostdiseasefollowingallogeneicstemcelltransplantationanddonorlymphocyteinfusionruleorexception AT maaikemeyering durableremissionofrenalcellcarcinomainconjuncturewithgraftversushostdiseasefollowingallogeneicstemcelltransplantationanddonorlymphocyteinfusionruleorexception AT jhfrederikfalkenburg durableremissionofrenalcellcarcinomainconjuncturewithgraftversushostdiseasefollowingallogeneicstemcelltransplantationanddonorlymphocyteinfusionruleorexception AT mariekegriffioen durableremissionofrenalcellcarcinomainconjuncturewithgraftversushostdiseasefollowingallogeneicstemcelltransplantationanddonorlymphocyteinfusionruleorexception AT susanneosanto durableremissionofrenalcellcarcinomainconjuncturewithgraftversushostdiseasefollowingallogeneicstemcelltransplantationanddonorlymphocyteinfusionruleorexception
_version_	1718421564228108288

Durable remission of renal cell carcinoma in conjuncture with graft versus host disease following allogeneic stem cell transplantation and donor lymphocyte infusion: rule or exception?

Ejemplares similares