Comparison of the Scorpionism Caused by Centruroides margaritatus, Tityus pachyurus and Tityus n. sp. aff. metuendus Scorpion Venoms in Colombia

Among other scorpion species, Colombia has two genera of the Buthidae family Centruroides and Tityus, considered to be dangerous to humans. This research shares scientific knowledge aiming to a better understanding about the pathophysiological effects of such ve...

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Autores principales:	Leydy Lorena Mendoza-Tobar, Ivonne Alejandra Meza-Cabrera, Juan C. Sepúlveda-Arias, Jimmy Alexander Guerrero-Vargas
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	scorpionism <i>Tityus pachyurus</i> <i>Centruroides margaritatus</i> <i>Tityus</i> n. sp. aff. <i>metuendus</i> histopathology phyisiopathology Colombia Medicine R
Acceso en línea:	https://doaj.org/article/670ef9e0fed446808f680f8ad7e11ae8
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id	oai:doaj.org-article:670ef9e0fed446808f680f8ad7e11ae8
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spelling	oai:doaj.org-article:670ef9e0fed446808f680f8ad7e11ae82021-11-25T19:08:36ZComparison of the Scorpionism Caused by <i>Centruroides</i> <i>margaritatus</i>, <i>Tityus</i> <i>pachyurus</i> and <i>Tityus</i> n. sp. aff. <i>metuendus</i> Scorpion Venoms in Colombia10.3390/toxins131107572072-6651https://doaj.org/article/670ef9e0fed446808f680f8ad7e11ae82021-10-01T00:00:00Zhttps://www.mdpi.com/2072-6651/13/11/757https://doaj.org/toc/2072-6651Among other scorpion species, Colombia has two genera of the Buthidae family <i>Centruroides</i> and <i>Tityus,</i> considered to be dangerous to humans. This research shares scientific knowledge aiming to a better understanding about the pathophysiological effects of such venoms. The venom of the three species: <i>Centruroides margaritarus</i>, <i>Tityus pachyurus</i>, and <i>T</i>. n. sp. aff. <i>metuendus</i> with biomedical interest were studied. An initial pre-glycemic sample was taken from ICR mice. They were later intraperitoneally inoculated with doses of 35% and 70% of LD<sub>50</sub> of total venom. Poisoning signs were observed during a 6-h period to determine the level of scorpionism. After observation, a second glycemic sample was taken, and a histopathological evaluation of different organs was performed. This work revealed that all three venoms showed considerably notorious histopathological alterations in main organs such as heart and lungs; and inducing multiple organ failure, in relation to the glycemia values, only <i>C. margaritatus</i> and <i>T.</i> n. sp. aff. <i>metuendus</i> showed significant changes through manifestation of hyperglycemia. According to the Colombian scorpionism level; signs were mild to severe affecting the autonomous nervous system.Leydy Lorena Mendoza-TobarIvonne Alejandra Meza-CabreraJuan C. Sepúlveda-AriasJimmy Alexander Guerrero-VargasMDPI AGarticlescorpionism<i>Tityus pachyurus</i><i>Centruroides margaritatus</i><i>Tityus</i> n. sp. aff. <i>metuendus</i> histopathologyphyisiopathologyColombiaMedicineRENToxins, Vol 13, Iss 757, p 757 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	scorpionism <i>Tityus pachyurus</i> <i>Centruroides margaritatus</i> <i>Tityus</i> n. sp. aff. <i>metuendus</i> histopathology phyisiopathology Colombia Medicine R
spellingShingle	scorpionism <i>Tityus pachyurus</i> <i>Centruroides margaritatus</i> <i>Tityus</i> n. sp. aff. <i>metuendus</i> histopathology phyisiopathology Colombia Medicine R Leydy Lorena Mendoza-Tobar Ivonne Alejandra Meza-Cabrera Juan C. Sepúlveda-Arias Jimmy Alexander Guerrero-Vargas Comparison of the Scorpionism Caused by <i>Centruroides</i> <i>margaritatus</i>, <i>Tityus</i> <i>pachyurus</i> and <i>Tityus</i> n. sp. aff. <i>metuendus</i> Scorpion Venoms in Colombia
description	Among other scorpion species, Colombia has two genera of the Buthidae family <i>Centruroides</i> and <i>Tityus,</i> considered to be dangerous to humans. This research shares scientific knowledge aiming to a better understanding about the pathophysiological effects of such venoms. The venom of the three species: <i>Centruroides margaritarus</i>, <i>Tityus pachyurus</i>, and <i>T</i>. n. sp. aff. <i>metuendus</i> with biomedical interest were studied. An initial pre-glycemic sample was taken from ICR mice. They were later intraperitoneally inoculated with doses of 35% and 70% of LD<sub>50</sub> of total venom. Poisoning signs were observed during a 6-h period to determine the level of scorpionism. After observation, a second glycemic sample was taken, and a histopathological evaluation of different organs was performed. This work revealed that all three venoms showed considerably notorious histopathological alterations in main organs such as heart and lungs; and inducing multiple organ failure, in relation to the glycemia values, only <i>C. margaritatus</i> and <i>T.</i> n. sp. aff. <i>metuendus</i> showed significant changes through manifestation of hyperglycemia. According to the Colombian scorpionism level; signs were mild to severe affecting the autonomous nervous system.
format	article
author	Leydy Lorena Mendoza-Tobar Ivonne Alejandra Meza-Cabrera Juan C. Sepúlveda-Arias Jimmy Alexander Guerrero-Vargas
author_facet	Leydy Lorena Mendoza-Tobar Ivonne Alejandra Meza-Cabrera Juan C. Sepúlveda-Arias Jimmy Alexander Guerrero-Vargas
author_sort	Leydy Lorena Mendoza-Tobar
title	Comparison of the Scorpionism Caused by <i>Centruroides</i> <i>margaritatus</i>, <i>Tityus</i> <i>pachyurus</i> and <i>Tityus</i> n. sp. aff. <i>metuendus</i> Scorpion Venoms in Colombia
title_short	Comparison of the Scorpionism Caused by <i>Centruroides</i> <i>margaritatus</i>, <i>Tityus</i> <i>pachyurus</i> and <i>Tityus</i> n. sp. aff. <i>metuendus</i> Scorpion Venoms in Colombia
title_full	Comparison of the Scorpionism Caused by <i>Centruroides</i> <i>margaritatus</i>, <i>Tityus</i> <i>pachyurus</i> and <i>Tityus</i> n. sp. aff. <i>metuendus</i> Scorpion Venoms in Colombia
title_fullStr	Comparison of the Scorpionism Caused by <i>Centruroides</i> <i>margaritatus</i>, <i>Tityus</i> <i>pachyurus</i> and <i>Tityus</i> n. sp. aff. <i>metuendus</i> Scorpion Venoms in Colombia
title_full_unstemmed	Comparison of the Scorpionism Caused by <i>Centruroides</i> <i>margaritatus</i>, <i>Tityus</i> <i>pachyurus</i> and <i>Tityus</i> n. sp. aff. <i>metuendus</i> Scorpion Venoms in Colombia
title_sort	comparison of the scorpionism caused by <i>centruroides</i> <i>margaritatus</i>, <i>tityus</i> <i>pachyurus</i> and <i>tityus</i> n. sp. aff. <i>metuendus</i> scorpion venoms in colombia
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/670ef9e0fed446808f680f8ad7e11ae8
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Comparison of the Scorpionism Caused by <i>Centruroides</i> <i>margaritatus</i>, <i>Tityus</i> <i>pachyurus</i> and <i>Tityus</i> n. sp. aff. <i>metuendus</i> Scorpion Venoms in Colombia

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