Coordinated labio-lingual asymmetries in dental and bone development create a symmetrical acrodont dentition

Abstract Organs throughout the body develop both asymmetrically and symmetrically. Here, we assess how symmetrical teeth in reptiles can be created from asymmetrical tooth germs. Teeth of lepidosaurian reptiles are mostly anchored to the jaw bones by pleurodont ankylosis, where the tooth is held in...

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Autores principales:	M. Kavková, M. Šulcová, J. Dumková, O. Zahradníček, J. Kaiser, A. S. Tucker, T. Zikmund, M. Buchtová
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/670f068f1570408d8b730dd24102f70a
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spelling	oai:doaj.org-article:670f068f1570408d8b730dd24102f70a2021-12-02T13:34:10ZCoordinated labio-lingual asymmetries in dental and bone development create a symmetrical acrodont dentition10.1038/s41598-020-78939-22045-2322https://doaj.org/article/670f068f1570408d8b730dd24102f70a2020-12-01T00:00:00Zhttps://doi.org/10.1038/s41598-020-78939-2https://doaj.org/toc/2045-2322Abstract Organs throughout the body develop both asymmetrically and symmetrically. Here, we assess how symmetrical teeth in reptiles can be created from asymmetrical tooth germs. Teeth of lepidosaurian reptiles are mostly anchored to the jaw bones by pleurodont ankylosis, where the tooth is held in place on the labial side only. Pleurodont teeth are characterized by significantly asymmetrical development of the labial and lingual sides of the cervical loop, which later leads to uneven deposition of hard tissue. On the other hand, acrodont teeth found in lizards of the Acrodonta clade (i.e. agamas, chameleons) are symmetrically ankylosed to the jaw bone. Here, we have focused on the formation of the symmetrical acrodont dentition of the veiled chameleon (Chamaeleo calyptratus). Intriguingly, our results revealed distinct asymmetries in morphology of the labial and lingual sides of the cervical loop during early developmental stages, both at the gross and ultrastructural level, with specific patterns of cell proliferation and stem cell marker expression. Asymmetrical expression of ST14 was also observed, with a positive domain on the lingual side of the cervical loop overlapping with the SOX2 domain. In contrast, micro-CT analysis of hard tissues revealed that deposition of dentin and enamel was largely symmetrical at the mineralization stage, highlighting the difference between cervical loop morphology during early development and differentiation of odontoblasts throughout later odontogenesis. In conclusion, the early asymmetrical development of the enamel organ seems to be a plesiomorphic character for all squamate reptiles, while symmetrical and precisely orchestrated deposition of hard tissue during tooth formation in acrodont dentitions probably represents a novelty in the Acrodonta clade.M. KavkováM. ŠulcováJ. DumkováO. ZahradníčekJ. KaiserA. S. TuckerT. ZikmundM. BuchtováNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 10, Iss 1, Pp 1-16 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q M. Kavková M. Šulcová J. Dumková O. Zahradníček J. Kaiser A. S. Tucker T. Zikmund M. Buchtová Coordinated labio-lingual asymmetries in dental and bone development create a symmetrical acrodont dentition
description	Abstract Organs throughout the body develop both asymmetrically and symmetrically. Here, we assess how symmetrical teeth in reptiles can be created from asymmetrical tooth germs. Teeth of lepidosaurian reptiles are mostly anchored to the jaw bones by pleurodont ankylosis, where the tooth is held in place on the labial side only. Pleurodont teeth are characterized by significantly asymmetrical development of the labial and lingual sides of the cervical loop, which later leads to uneven deposition of hard tissue. On the other hand, acrodont teeth found in lizards of the Acrodonta clade (i.e. agamas, chameleons) are symmetrically ankylosed to the jaw bone. Here, we have focused on the formation of the symmetrical acrodont dentition of the veiled chameleon (Chamaeleo calyptratus). Intriguingly, our results revealed distinct asymmetries in morphology of the labial and lingual sides of the cervical loop during early developmental stages, both at the gross and ultrastructural level, with specific patterns of cell proliferation and stem cell marker expression. Asymmetrical expression of ST14 was also observed, with a positive domain on the lingual side of the cervical loop overlapping with the SOX2 domain. In contrast, micro-CT analysis of hard tissues revealed that deposition of dentin and enamel was largely symmetrical at the mineralization stage, highlighting the difference between cervical loop morphology during early development and differentiation of odontoblasts throughout later odontogenesis. In conclusion, the early asymmetrical development of the enamel organ seems to be a plesiomorphic character for all squamate reptiles, while symmetrical and precisely orchestrated deposition of hard tissue during tooth formation in acrodont dentitions probably represents a novelty in the Acrodonta clade.
format	article
author	M. Kavková M. Šulcová J. Dumková O. Zahradníček J. Kaiser A. S. Tucker T. Zikmund M. Buchtová
author_facet	M. Kavková M. Šulcová J. Dumková O. Zahradníček J. Kaiser A. S. Tucker T. Zikmund M. Buchtová
author_sort	M. Kavková
title	Coordinated labio-lingual asymmetries in dental and bone development create a symmetrical acrodont dentition
title_short	Coordinated labio-lingual asymmetries in dental and bone development create a symmetrical acrodont dentition
title_full	Coordinated labio-lingual asymmetries in dental and bone development create a symmetrical acrodont dentition
title_fullStr	Coordinated labio-lingual asymmetries in dental and bone development create a symmetrical acrodont dentition
title_full_unstemmed	Coordinated labio-lingual asymmetries in dental and bone development create a symmetrical acrodont dentition
title_sort	coordinated labio-lingual asymmetries in dental and bone development create a symmetrical acrodont dentition
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/670f068f1570408d8b730dd24102f70a
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Coordinated labio-lingual asymmetries in dental and bone development create a symmetrical acrodont dentition

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