Cariprazine in Three Acute Patients with Schizophrenia: A Real-World Experience

Jose M Montes,1 Paloma Montes,2 Daniel Hernández-Huerta3 1Psychiatry Service, CIBERSAM, IRYCIS, Hospital Universitario Ramóny Cajal, Madrid, Spain; 2Psychiatry Service, Hospital Universitario de Móstoles Madrid, Spain; 3Psychiatry Service, Hospital Universitario Ram&...

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Autores principales:	Montes JM, Montes P, Hernández-Huerta D
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2021
Materias:	schizophrenia cariprazine antipsychotics negative symptoms case report Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
Acceso en línea:	https://doaj.org/article/67129604ad4b4012a2dbf1770babe8cd
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spelling	oai:doaj.org-article:67129604ad4b4012a2dbf1770babe8cd2021-12-02T14:14:59ZCariprazine in Three Acute Patients with Schizophrenia: A Real-World Experience1178-2021https://doaj.org/article/67129604ad4b4012a2dbf1770babe8cd2021-02-01T00:00:00Zhttps://www.dovepress.com/cariprazine-in-three-acute-patients-with-schizophrenia-a-real-world-ex-peer-reviewed-article-NDThttps://doaj.org/toc/1178-2021Jose M Montes,1 Paloma Montes,2 Daniel Hernández-Huerta3 1Psychiatry Service, CIBERSAM, IRYCIS, Hospital Universitario Ramóny Cajal, Madrid, Spain; 2Psychiatry Service, Hospital Universitario de Móstoles Madrid, Spain; 3Psychiatry Service, Hospital Universitario Ramón y Cajal, Madrid, SpainCorrespondence: Jose M MontesPsychiatry Service, Hospital Universitario Ramón y Cajal, Carretera Colmenar Km 9,1, Madrid, 28034, SpainTel +34 91 336 9152Fax +34 91 336 8483Email j_m_montes@hotmail.comAbstract: There are still some unmet needs in the treatment of schizophrenia like the persistence of negative symptoms. Cariprazine is a new-generation antipsychotic with partial agonism of the dopamine receptors, distinct from other antipsychotics by its 10 times greater affinity for D3 receptors. This mechanism of action could be especially favorable on patients with predominant negative symptoms. This report is showing three clinical cases of acute schizophrenia exacerbation that required hospitalization and were successfully treated with cariprazine. All of them had predominant positive symptoms and two of them had substance use. Efficacy of cariprazine was also crucial on negative and cognitive symptoms with excellent tolerability.Keywords: schizophrenia, cariprazine, antipsychotics, negative symptoms, case reportMontes JMMontes PHernández-Huerta DDove Medical Pressarticleschizophreniacariprazineantipsychoticsnegative symptomscase reportNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571Neurology. Diseases of the nervous systemRC346-429ENNeuropsychiatric Disease and Treatment, Vol Volume 17, Pp 291-296 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	schizophrenia cariprazine antipsychotics negative symptoms case report Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
spellingShingle	schizophrenia cariprazine antipsychotics negative symptoms case report Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429 Montes JM Montes P Hernández-Huerta D Cariprazine in Three Acute Patients with Schizophrenia: A Real-World Experience
description	Jose M Montes,1 Paloma Montes,2 Daniel Hernández-Huerta3 1Psychiatry Service, CIBERSAM, IRYCIS, Hospital Universitario Ramóny Cajal, Madrid, Spain; 2Psychiatry Service, Hospital Universitario de Móstoles Madrid, Spain; 3Psychiatry Service, Hospital Universitario Ramón y Cajal, Madrid, SpainCorrespondence: Jose M MontesPsychiatry Service, Hospital Universitario Ramón y Cajal, Carretera Colmenar Km 9,1, Madrid, 28034, SpainTel +34 91 336 9152Fax +34 91 336 8483Email j_m_montes@hotmail.comAbstract: There are still some unmet needs in the treatment of schizophrenia like the persistence of negative symptoms. Cariprazine is a new-generation antipsychotic with partial agonism of the dopamine receptors, distinct from other antipsychotics by its 10 times greater affinity for D3 receptors. This mechanism of action could be especially favorable on patients with predominant negative symptoms. This report is showing three clinical cases of acute schizophrenia exacerbation that required hospitalization and were successfully treated with cariprazine. All of them had predominant positive symptoms and two of them had substance use. Efficacy of cariprazine was also crucial on negative and cognitive symptoms with excellent tolerability.Keywords: schizophrenia, cariprazine, antipsychotics, negative symptoms, case report
format	article
author	Montes JM Montes P Hernández-Huerta D
author_facet	Montes JM Montes P Hernández-Huerta D
author_sort	Montes JM
title	Cariprazine in Three Acute Patients with Schizophrenia: A Real-World Experience
title_short	Cariprazine in Three Acute Patients with Schizophrenia: A Real-World Experience
title_full	Cariprazine in Three Acute Patients with Schizophrenia: A Real-World Experience
title_fullStr	Cariprazine in Three Acute Patients with Schizophrenia: A Real-World Experience
title_full_unstemmed	Cariprazine in Three Acute Patients with Schizophrenia: A Real-World Experience
title_sort	cariprazine in three acute patients with schizophrenia: a real-world experience
publisher	Dove Medical Press
publishDate	2021
url	https://doaj.org/article/67129604ad4b4012a2dbf1770babe8cd
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Cariprazine in Three Acute Patients with Schizophrenia: A Real-World Experience

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