Photobiomodulation has rejuvenating effects on aged bone marrow mesenchymal stem cells

Abstract The plasticity and proliferative capacity of stem cells decrease with aging, compromising their tissue regenerative potential and therapeutic applications. This decline is directly linked to mitochondrial dysfunction. Here, we present an effective strategy to reverse aging of mouse bone mar...

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Autores principales:	Binnur Eroglu, Evan Genova, Quanguang Zhang, Yun Su, Xingming Shi, Carlos Isales, Ali Eroglu
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/6712ff8964f54ec9829463fbffb61606
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spelling	oai:doaj.org-article:6712ff8964f54ec9829463fbffb616062021-12-02T16:07:04ZPhotobiomodulation has rejuvenating effects on aged bone marrow mesenchymal stem cells10.1038/s41598-021-92584-32045-2322https://doaj.org/article/6712ff8964f54ec9829463fbffb616062021-06-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-92584-3https://doaj.org/toc/2045-2322Abstract The plasticity and proliferative capacity of stem cells decrease with aging, compromising their tissue regenerative potential and therapeutic applications. This decline is directly linked to mitochondrial dysfunction. Here, we present an effective strategy to reverse aging of mouse bone marrow mesenchymal stem cells (BM-MSCs) by restoring their mitochondrial functionality using photobiomodulation (PBM) therapy. Following the characterization of young and aged MSCs, our results show that a near-infrared PBM treatment delivering 3 J/cm2 is the most effective modality for improving mitochondrial functionality and aging markers. Furthermore, our results unveil that young and aged MSCs respond differently to the same modality of PBM: whereas the beneficial effect of a single PBM treatment dissipates within 7 h in aged stem cells, it is lasting in young ones. Nevertheless, by applying three consecutive treatments at 24-h intervals, we were able to obtain a lasting rejuvenating effect on aged MSCs. Our findings are of particular significance for improving autologous stem cell transplantation in older individuals who need such therapies most.Binnur ErogluEvan GenovaQuanguang ZhangYun SuXingming ShiCarlos IsalesAli ErogluNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-18 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Binnur Eroglu Evan Genova Quanguang Zhang Yun Su Xingming Shi Carlos Isales Ali Eroglu Photobiomodulation has rejuvenating effects on aged bone marrow mesenchymal stem cells
description	Abstract The plasticity and proliferative capacity of stem cells decrease with aging, compromising their tissue regenerative potential and therapeutic applications. This decline is directly linked to mitochondrial dysfunction. Here, we present an effective strategy to reverse aging of mouse bone marrow mesenchymal stem cells (BM-MSCs) by restoring their mitochondrial functionality using photobiomodulation (PBM) therapy. Following the characterization of young and aged MSCs, our results show that a near-infrared PBM treatment delivering 3 J/cm2 is the most effective modality for improving mitochondrial functionality and aging markers. Furthermore, our results unveil that young and aged MSCs respond differently to the same modality of PBM: whereas the beneficial effect of a single PBM treatment dissipates within 7 h in aged stem cells, it is lasting in young ones. Nevertheless, by applying three consecutive treatments at 24-h intervals, we were able to obtain a lasting rejuvenating effect on aged MSCs. Our findings are of particular significance for improving autologous stem cell transplantation in older individuals who need such therapies most.
format	article
author	Binnur Eroglu Evan Genova Quanguang Zhang Yun Su Xingming Shi Carlos Isales Ali Eroglu
author_facet	Binnur Eroglu Evan Genova Quanguang Zhang Yun Su Xingming Shi Carlos Isales Ali Eroglu
author_sort	Binnur Eroglu
title	Photobiomodulation has rejuvenating effects on aged bone marrow mesenchymal stem cells
title_short	Photobiomodulation has rejuvenating effects on aged bone marrow mesenchymal stem cells
title_full	Photobiomodulation has rejuvenating effects on aged bone marrow mesenchymal stem cells
title_fullStr	Photobiomodulation has rejuvenating effects on aged bone marrow mesenchymal stem cells
title_full_unstemmed	Photobiomodulation has rejuvenating effects on aged bone marrow mesenchymal stem cells
title_sort	photobiomodulation has rejuvenating effects on aged bone marrow mesenchymal stem cells
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/6712ff8964f54ec9829463fbffb61606
work_keys_str_mv	AT binnureroglu photobiomodulationhasrejuvenatingeffectsonagedbonemarrowmesenchymalstemcells AT evangenova photobiomodulationhasrejuvenatingeffectsonagedbonemarrowmesenchymalstemcells AT quanguangzhang photobiomodulationhasrejuvenatingeffectsonagedbonemarrowmesenchymalstemcells AT yunsu photobiomodulationhasrejuvenatingeffectsonagedbonemarrowmesenchymalstemcells AT xingmingshi photobiomodulationhasrejuvenatingeffectsonagedbonemarrowmesenchymalstemcells AT carlosisales photobiomodulationhasrejuvenatingeffectsonagedbonemarrowmesenchymalstemcells AT alieroglu photobiomodulationhasrejuvenatingeffectsonagedbonemarrowmesenchymalstemcells
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Photobiomodulation has rejuvenating effects on aged bone marrow mesenchymal stem cells

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