The underlying mechanisms for severe COVID-19 progression in people with diabetes mellitus: a critical review

Diabetes mellitus (DM) has a high incidence of comorbidities among patients with severe coronavirus disease 2019 (COVID-19). The elevated prevalence of DM in the world population makes it a significant risk factor because diabetic individuals appear to be prone to clinical complications and have inc...

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Autores principales:	María D Figueroa-Pizano, Alma C Campa-Mada, Elizabeth Carvajal-Millan, Karla G Martinez-Robinson, Agustin Rascon Chu
Formato:	article
Lenguaje:	EN
Publicado:	AIMS Press 2021
Materias:	covid-19 diabetes mellitus chronic inflammation impaired immune system sars-cov-2 receptor ace2 polymorphisms diabetogenic effect Public aspects of medicine RA1-1270
Acceso en línea:	https://doaj.org/article/67170a1c38a745f78c1bca36d0fbd36e
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spelling	oai:doaj.org-article:67170a1c38a745f78c1bca36d0fbd36e2021-11-30T01:43:21ZThe underlying mechanisms for severe COVID-19 progression in people with diabetes mellitus: a critical review10.3934/publichealth.20210572327-8994https://doaj.org/article/67170a1c38a745f78c1bca36d0fbd36e2021-10-01T00:00:00Zhttps://www.aimspress.com/article/doi/10.3934/publichealth.2021057?viewType=HTMLhttps://doaj.org/toc/2327-8994Diabetes mellitus (DM) has a high incidence of comorbidities among patients with severe coronavirus disease 2019 (COVID-19). The elevated prevalence of DM in the world population makes it a significant risk factor because diabetic individuals appear to be prone to clinical complications and have increased mortality rates. Here, we review the possible underlying mechanisms involved in DM that led to worse outcomes in COVID-19. The impacts of hyperglycemia side effects, secondary comorbidities, weakened innate and adaptive immunity, chronic inflammation, and poor nutritional status, commonly present in DM, are discussed. The role of the SARS-CoV-2 receptor and its polymorphic variations on higher binding affinity to facilitate viral uptake in people with DM were also considered. Clinical differences between individuals with type 1 DM and type 2 DM affected by COVID-19 and the potential diabetogenic effect of SARS-CoV-2 infection were addressed.María D Figueroa-PizanoAlma C Campa-MadaElizabeth Carvajal-Millan Karla G Martinez-Robinson Agustin Rascon ChuAIMS Pressarticlecovid-19diabetes mellituschronic inflammationimpaired immune systemsars-cov-2 receptorace2 polymorphismsdiabetogenic effectPublic aspects of medicineRA1-1270ENAIMS Public Health, Vol 8, Iss 4, Pp 720-742 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	covid-19 diabetes mellitus chronic inflammation impaired immune system sars-cov-2 receptor ace2 polymorphisms diabetogenic effect Public aspects of medicine RA1-1270
spellingShingle	covid-19 diabetes mellitus chronic inflammation impaired immune system sars-cov-2 receptor ace2 polymorphisms diabetogenic effect Public aspects of medicine RA1-1270 María D Figueroa-Pizano Alma C Campa-Mada Elizabeth Carvajal-Millan Karla G Martinez-Robinson Agustin Rascon Chu The underlying mechanisms for severe COVID-19 progression in people with diabetes mellitus: a critical review
description	Diabetes mellitus (DM) has a high incidence of comorbidities among patients with severe coronavirus disease 2019 (COVID-19). The elevated prevalence of DM in the world population makes it a significant risk factor because diabetic individuals appear to be prone to clinical complications and have increased mortality rates. Here, we review the possible underlying mechanisms involved in DM that led to worse outcomes in COVID-19. The impacts of hyperglycemia side effects, secondary comorbidities, weakened innate and adaptive immunity, chronic inflammation, and poor nutritional status, commonly present in DM, are discussed. The role of the SARS-CoV-2 receptor and its polymorphic variations on higher binding affinity to facilitate viral uptake in people with DM were also considered. Clinical differences between individuals with type 1 DM and type 2 DM affected by COVID-19 and the potential diabetogenic effect of SARS-CoV-2 infection were addressed.
format	article
author	María D Figueroa-Pizano Alma C Campa-Mada Elizabeth Carvajal-Millan Karla G Martinez-Robinson Agustin Rascon Chu
author_facet	María D Figueroa-Pizano Alma C Campa-Mada Elizabeth Carvajal-Millan Karla G Martinez-Robinson Agustin Rascon Chu
author_sort	María D Figueroa-Pizano
title	The underlying mechanisms for severe COVID-19 progression in people with diabetes mellitus: a critical review
title_short	The underlying mechanisms for severe COVID-19 progression in people with diabetes mellitus: a critical review
title_full	The underlying mechanisms for severe COVID-19 progression in people with diabetes mellitus: a critical review
title_fullStr	The underlying mechanisms for severe COVID-19 progression in people with diabetes mellitus: a critical review
title_full_unstemmed	The underlying mechanisms for severe COVID-19 progression in people with diabetes mellitus: a critical review
title_sort	underlying mechanisms for severe covid-19 progression in people with diabetes mellitus: a critical review
publisher	AIMS Press
publishDate	2021
url	https://doaj.org/article/67170a1c38a745f78c1bca36d0fbd36e
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The underlying mechanisms for severe COVID-19 progression in people with diabetes mellitus: a critical review

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