ROLE OF СD14 AND CYTOKINE GENE POLYMORPHISM IN CLINICAL FEATURES AND OUTCOMES OF NOSOCOMIAL PNEUMONIA

Abstract. This article is devoted to analysis of gene polymorphisms affecting CD14 regulatory molecule, as well as IL-1β, TNFα cytokines and IL-1RN in the patients with nosocomial pneumonias. The influence of single-nucleotide substitution polymorphisms is discussed in terms of clinical severity and...

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Autores principales:	E. A. Baygosina, V. I. Sovalkin
Formato:	article
Lenguaje:	RU
Publicado:	SPb RAACI 2014
Materias:	gene polymorphism cd14 cytokines nosocomial pneumonia Immunologic diseases. Allergy RC581-607
Acceso en línea:	https://doaj.org/article/6717c6dc47e94595b085b15b8ddc8021
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spelling	oai:doaj.org-article:6717c6dc47e94595b085b15b8ddc80212021-11-18T08:03:39ZROLE OF СD14 AND CYTOKINE GENE POLYMORPHISM IN CLINICAL FEATURES AND OUTCOMES OF NOSOCOMIAL PNEUMONIA1563-06252313-741X10.15789/1563-0625-2008-4-5-467-472https://doaj.org/article/6717c6dc47e94595b085b15b8ddc80212014-07-01T00:00:00Zhttps://www.mimmun.ru/mimmun/article/view/223https://doaj.org/toc/1563-0625https://doaj.org/toc/2313-741XAbstract. This article is devoted to analysis of gene polymorphisms affecting CD14 regulatory molecule, as well as IL-1β, TNFα cytokines and IL-1RN in the patients with nosocomial pneumonias. The influence of single-nucleotide substitution polymorphisms is discussed in terms of clinical severity and outcomes of nosocomial pneumonia. A predisposition for more severe clinical course of pneumonia is revealed in a group of patients with C/Т and Т/Т genotypes of CD14 regulatory molecule. A carriership of –511Т аllele in the patients’ genotype predisposed for reduced terms of pneumonia evolution, like as development of acute respiratory distress syndrome and more pronounced acute phase response (leukocytosis and high levels of C-reactive protein). IL-RN2 allele was associated with generally poor outcome, whereas presence of –308 (AG, AA) variant of TNFα polymorphic gene was connected with pulmonary and extrapulmonary complications of nosocomial pneumonia. (Med. Immunol., vol. 10, N 4-5, pp 467-472).E. A. BaygosinaV. I. SovalkinSPb RAACIarticlegene polymorphismcd14cytokinesnosocomial pneumoniaImmunologic diseases. AllergyRC581-607RUMedicinskaâ Immunologiâ, Vol 10, Iss 4-5, Pp 467-472 (2014)
institution	DOAJ
collection	DOAJ
language	RU
topic	gene polymorphism cd14 cytokines nosocomial pneumonia Immunologic diseases. Allergy RC581-607
spellingShingle	gene polymorphism cd14 cytokines nosocomial pneumonia Immunologic diseases. Allergy RC581-607 E. A. Baygosina V. I. Sovalkin ROLE OF СD14 AND CYTOKINE GENE POLYMORPHISM IN CLINICAL FEATURES AND OUTCOMES OF NOSOCOMIAL PNEUMONIA
description	Abstract. This article is devoted to analysis of gene polymorphisms affecting CD14 regulatory molecule, as well as IL-1β, TNFα cytokines and IL-1RN in the patients with nosocomial pneumonias. The influence of single-nucleotide substitution polymorphisms is discussed in terms of clinical severity and outcomes of nosocomial pneumonia. A predisposition for more severe clinical course of pneumonia is revealed in a group of patients with C/Т and Т/Т genotypes of CD14 regulatory molecule. A carriership of –511Т аllele in the patients’ genotype predisposed for reduced terms of pneumonia evolution, like as development of acute respiratory distress syndrome and more pronounced acute phase response (leukocytosis and high levels of C-reactive protein). IL-RN2 allele was associated with generally poor outcome, whereas presence of –308 (AG, AA) variant of TNFα polymorphic gene was connected with pulmonary and extrapulmonary complications of nosocomial pneumonia. (Med. Immunol., vol. 10, N 4-5, pp 467-472).
format	article
author	E. A. Baygosina V. I. Sovalkin
author_facet	E. A. Baygosina V. I. Sovalkin
author_sort	E. A. Baygosina
title	ROLE OF СD14 AND CYTOKINE GENE POLYMORPHISM IN CLINICAL FEATURES AND OUTCOMES OF NOSOCOMIAL PNEUMONIA
title_short	ROLE OF СD14 AND CYTOKINE GENE POLYMORPHISM IN CLINICAL FEATURES AND OUTCOMES OF NOSOCOMIAL PNEUMONIA
title_full	ROLE OF СD14 AND CYTOKINE GENE POLYMORPHISM IN CLINICAL FEATURES AND OUTCOMES OF NOSOCOMIAL PNEUMONIA
title_fullStr	ROLE OF СD14 AND CYTOKINE GENE POLYMORPHISM IN CLINICAL FEATURES AND OUTCOMES OF NOSOCOMIAL PNEUMONIA
title_full_unstemmed	ROLE OF СD14 AND CYTOKINE GENE POLYMORPHISM IN CLINICAL FEATURES AND OUTCOMES OF NOSOCOMIAL PNEUMONIA
title_sort	role of сd14 and cytokine gene polymorphism in clinical features and outcomes of nosocomial pneumonia
publisher	SPb RAACI
publishDate	2014
url	https://doaj.org/article/6717c6dc47e94595b085b15b8ddc8021
work_keys_str_mv	AT eabaygosina roleofsd14andcytokinegenepolymorphisminclinicalfeaturesandoutcomesofnosocomialpneumonia AT visovalkin roleofsd14andcytokinegenepolymorphisminclinicalfeaturesandoutcomesofnosocomialpneumonia
_version_	1718422547869990912

ROLE OF СD14 AND CYTOKINE GENE POLYMORPHISM IN CLINICAL FEATURES AND OUTCOMES OF NOSOCOMIAL PNEUMONIA

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