Skeletal stem and progenitor cells maintain cranial suture patency and prevent craniosynostosis

Cranial sutures are major growth centers for the skull vault and premature fusion leads to pathological fusion, craniosynostosis. Here the authors isolate Wnt responsive skeletal stem and progenitor cells from sutures, that can be transplanted together with Wnt3a protein to repair craniosynostosis i...

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Autores principales:	Siddharth Menon, Ankit Salhotra, Siny Shailendra, Ruth Tevlin, Ryan C. Ransom, Michael Januszyk, Charles K. F. Chan, Björn Behr, Derrick C. Wan, Michael T. Longaker, Natalina Quarto
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/671b4fb52e1c487f869afe46a4fd3690
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spelling	oai:doaj.org-article:671b4fb52e1c487f869afe46a4fd36902021-12-02T16:13:27ZSkeletal stem and progenitor cells maintain cranial suture patency and prevent craniosynostosis10.1038/s41467-021-24801-62041-1723https://doaj.org/article/671b4fb52e1c487f869afe46a4fd36902021-07-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-24801-6https://doaj.org/toc/2041-1723Cranial sutures are major growth centers for the skull vault and premature fusion leads to pathological fusion, craniosynostosis. Here the authors isolate Wnt responsive skeletal stem and progenitor cells from sutures, that can be transplanted together with Wnt3a protein to repair craniosynostosis in a mouse model.Siddharth MenonAnkit SalhotraSiny ShailendraRuth TevlinRyan C. RansomMichael JanuszykCharles K. F. ChanBjörn BehrDerrick C. WanMichael T. LongakerNatalina QuartoNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Siddharth Menon Ankit Salhotra Siny Shailendra Ruth Tevlin Ryan C. Ransom Michael Januszyk Charles K. F. Chan Björn Behr Derrick C. Wan Michael T. Longaker Natalina Quarto Skeletal stem and progenitor cells maintain cranial suture patency and prevent craniosynostosis
description	Cranial sutures are major growth centers for the skull vault and premature fusion leads to pathological fusion, craniosynostosis. Here the authors isolate Wnt responsive skeletal stem and progenitor cells from sutures, that can be transplanted together with Wnt3a protein to repair craniosynostosis in a mouse model.
format	article
author	Siddharth Menon Ankit Salhotra Siny Shailendra Ruth Tevlin Ryan C. Ransom Michael Januszyk Charles K. F. Chan Björn Behr Derrick C. Wan Michael T. Longaker Natalina Quarto
author_facet	Siddharth Menon Ankit Salhotra Siny Shailendra Ruth Tevlin Ryan C. Ransom Michael Januszyk Charles K. F. Chan Björn Behr Derrick C. Wan Michael T. Longaker Natalina Quarto
author_sort	Siddharth Menon
title	Skeletal stem and progenitor cells maintain cranial suture patency and prevent craniosynostosis
title_short	Skeletal stem and progenitor cells maintain cranial suture patency and prevent craniosynostosis
title_full	Skeletal stem and progenitor cells maintain cranial suture patency and prevent craniosynostosis
title_fullStr	Skeletal stem and progenitor cells maintain cranial suture patency and prevent craniosynostosis
title_full_unstemmed	Skeletal stem and progenitor cells maintain cranial suture patency and prevent craniosynostosis
title_sort	skeletal stem and progenitor cells maintain cranial suture patency and prevent craniosynostosis
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/671b4fb52e1c487f869afe46a4fd3690
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Skeletal stem and progenitor cells maintain cranial suture patency and prevent craniosynostosis

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