Transcriptome-wide Mendelian randomization study prioritising novel tissue-dependent genes for glioma susceptibility
Abstract Genome-wide association studies (GWAS) have discovered 27 loci associated with glioma risk. Whether these loci are causally implicated in glioma risk, and how risk differs across tissues, has yet to be systematically explored. We integrated multi-tissue expression quantitative trait loci (e...
Guardado en:
Autores principales: | Jamie W. Robinson, Richard M. Martin, Spiridon Tsavachidis, Amy E. Howell, Caroline L. Relton, Georgina N. Armstrong, Melissa Bondy, Jie Zheng, Kathreena M. Kurian |
---|---|
Formato: | article |
Lenguaje: | EN |
Publicado: |
Nature Portfolio
2021
|
Materias: | |
Acceso en línea: | https://doaj.org/article/671b6767142d465a88df9af27c9c410a |
Etiquetas: |
Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
|
Ejemplares similares
-
A transcriptome-wide Mendelian randomization study to uncover tissue-dependent regulatory mechanisms across the human phenome
por: Tom G. Richardson, et al.
Publicado: (2020) -
Testing and controlling for horizontal pleiotropy with probabilistic Mendelian randomization in transcriptome-wide association studies
por: Zhongshang Yuan, et al.
Publicado: (2020) -
Model checking via testing for direct effects in Mendelian Randomization and transcriptome-wide association studies.
por: Yangqing Deng, et al.
Publicado: (2021) -
Monitoring socio-climatic interactions to prioritise drinking water interventions in rural Africa
por: Andrew Armstrong, et al.
Publicado: (2021) -
A transcriptome-wide association study identifies susceptibility genes for Parkinson’s disease
por: Shi Yao, et al.
Publicado: (2021)