Light-driven decarboxylative deuteration enabled by a divergently engineered photodecarboxylase

The chemical processes for the selective incorporation of deuterium into small molecules, of interest to organic and medicinal chemistry, are well established, while the enzymatic methods remain underdeveloped. Here, the authors use an enzymatic approach employing Chlorella variabilis NC64A photodec...

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Autores principales:	Jian Xu, Jiajie Fan, Yujiao Lou, Weihua Xu, Zhiguo Wang, Danyang Li, Haonan Zhou, Xianfu Lin, Qi Wu
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/671c1dc0e8124a00b5cc1aca053d9f9f
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spelling	oai:doaj.org-article:671c1dc0e8124a00b5cc1aca053d9f9f2021-12-02T17:45:15ZLight-driven decarboxylative deuteration enabled by a divergently engineered photodecarboxylase10.1038/s41467-021-24259-62041-1723https://doaj.org/article/671c1dc0e8124a00b5cc1aca053d9f9f2021-06-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-24259-6https://doaj.org/toc/2041-1723The chemical processes for the selective incorporation of deuterium into small molecules, of interest to organic and medicinal chemistry, are well established, while the enzymatic methods remain underdeveloped. Here, the authors use an enzymatic approach employing Chlorella variabilis NC64A photodecarboxylase that catalyses decarboxylative deuteration of various carboxylic acids with D2O, and identify enzyme variants that can employ substrates with different chain length acids.Jian XuJiajie FanYujiao LouWeihua XuZhiguo WangDanyang LiHaonan ZhouXianfu LinQi WuNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-10 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Jian Xu Jiajie Fan Yujiao Lou Weihua Xu Zhiguo Wang Danyang Li Haonan Zhou Xianfu Lin Qi Wu Light-driven decarboxylative deuteration enabled by a divergently engineered photodecarboxylase
description	The chemical processes for the selective incorporation of deuterium into small molecules, of interest to organic and medicinal chemistry, are well established, while the enzymatic methods remain underdeveloped. Here, the authors use an enzymatic approach employing Chlorella variabilis NC64A photodecarboxylase that catalyses decarboxylative deuteration of various carboxylic acids with D2O, and identify enzyme variants that can employ substrates with different chain length acids.
format	article
author	Jian Xu Jiajie Fan Yujiao Lou Weihua Xu Zhiguo Wang Danyang Li Haonan Zhou Xianfu Lin Qi Wu
author_facet	Jian Xu Jiajie Fan Yujiao Lou Weihua Xu Zhiguo Wang Danyang Li Haonan Zhou Xianfu Lin Qi Wu
author_sort	Jian Xu
title	Light-driven decarboxylative deuteration enabled by a divergently engineered photodecarboxylase
title_short	Light-driven decarboxylative deuteration enabled by a divergently engineered photodecarboxylase
title_full	Light-driven decarboxylative deuteration enabled by a divergently engineered photodecarboxylase
title_fullStr	Light-driven decarboxylative deuteration enabled by a divergently engineered photodecarboxylase
title_full_unstemmed	Light-driven decarboxylative deuteration enabled by a divergently engineered photodecarboxylase
title_sort	light-driven decarboxylative deuteration enabled by a divergently engineered photodecarboxylase
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/671c1dc0e8124a00b5cc1aca053d9f9f
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Light-driven decarboxylative deuteration enabled by a divergently engineered photodecarboxylase

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