A Decade of Mighty Lipophagy: What We Know and What Facts We Need to Know?

Lipids are integral cellular components that act as substrates for energy provision, signaling molecules, and essential constituents of biological membranes along with a variety of other biological functions. Despite their significance, lipid accumulation may result in lipotoxicity, impair autophagy...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Muhammad Babar Khawar, Muddasir Hassan Abbasi, Mussarat Rafiq, Naila Naz, Rabia Mehmood, Nadeem Sheikh
Formato:	article
Lenguaje:	EN
Publicado:	Hindawi Limited 2021
Materias:	Cytology QH573-671
Acceso en línea:	https://doaj.org/article/67222b79b27e4c34b66187c657ce47d8
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:67222b79b27e4c34b66187c657ce47d8
record_format	dspace
spelling	oai:doaj.org-article:67222b79b27e4c34b66187c657ce47d82021-11-15T01:19:24ZA Decade of Mighty Lipophagy: What We Know and What Facts We Need to Know?1942-099410.1155/2021/5539161https://doaj.org/article/67222b79b27e4c34b66187c657ce47d82021-01-01T00:00:00Zhttp://dx.doi.org/10.1155/2021/5539161https://doaj.org/toc/1942-0994Lipids are integral cellular components that act as substrates for energy provision, signaling molecules, and essential constituents of biological membranes along with a variety of other biological functions. Despite their significance, lipid accumulation may result in lipotoxicity, impair autophagy, and lysosomal function that may lead to certain diseases and metabolic syndromes like obesity and even cell death. Therefore, these lipids are continuously recycled and redistributed by the process of selective autophagy specifically termed as lipophagy. This selective form of autophagy employs lysosomes for the maintenance of cellular lipid homeostasis. In this review, we have reviewed the current literature about how lipid droplets (LDs) are recruited towards lysosomes, cross-talk between a variety of autophagy receptors present on LD surface and lysosomes, and lipid hydrolysis by lysosomal enzymes. In addition to it, we have tried to answer most of the possible questions related to lipophagy regulation at different levels. Moreover, in the last part of this review, we have discussed some of the pathological states due to the accumulation of these LDs and their possible treatments under the light of currently available findings.Muhammad Babar KhawarMuddasir Hassan AbbasiMussarat RafiqNaila NazRabia MehmoodNadeem SheikhHindawi LimitedarticleCytologyQH573-671ENOxidative Medicine and Cellular Longevity, Vol 2021 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Cytology QH573-671
spellingShingle	Cytology QH573-671 Muhammad Babar Khawar Muddasir Hassan Abbasi Mussarat Rafiq Naila Naz Rabia Mehmood Nadeem Sheikh A Decade of Mighty Lipophagy: What We Know and What Facts We Need to Know?
description	Lipids are integral cellular components that act as substrates for energy provision, signaling molecules, and essential constituents of biological membranes along with a variety of other biological functions. Despite their significance, lipid accumulation may result in lipotoxicity, impair autophagy, and lysosomal function that may lead to certain diseases and metabolic syndromes like obesity and even cell death. Therefore, these lipids are continuously recycled and redistributed by the process of selective autophagy specifically termed as lipophagy. This selective form of autophagy employs lysosomes for the maintenance of cellular lipid homeostasis. In this review, we have reviewed the current literature about how lipid droplets (LDs) are recruited towards lysosomes, cross-talk between a variety of autophagy receptors present on LD surface and lysosomes, and lipid hydrolysis by lysosomal enzymes. In addition to it, we have tried to answer most of the possible questions related to lipophagy regulation at different levels. Moreover, in the last part of this review, we have discussed some of the pathological states due to the accumulation of these LDs and their possible treatments under the light of currently available findings.
format	article
author	Muhammad Babar Khawar Muddasir Hassan Abbasi Mussarat Rafiq Naila Naz Rabia Mehmood Nadeem Sheikh
author_facet	Muhammad Babar Khawar Muddasir Hassan Abbasi Mussarat Rafiq Naila Naz Rabia Mehmood Nadeem Sheikh
author_sort	Muhammad Babar Khawar
title	A Decade of Mighty Lipophagy: What We Know and What Facts We Need to Know?
title_short	A Decade of Mighty Lipophagy: What We Know and What Facts We Need to Know?
title_full	A Decade of Mighty Lipophagy: What We Know and What Facts We Need to Know?
title_fullStr	A Decade of Mighty Lipophagy: What We Know and What Facts We Need to Know?
title_full_unstemmed	A Decade of Mighty Lipophagy: What We Know and What Facts We Need to Know?
title_sort	decade of mighty lipophagy: what we know and what facts we need to know?
publisher	Hindawi Limited
publishDate	2021
url	https://doaj.org/article/67222b79b27e4c34b66187c657ce47d8
work_keys_str_mv	AT muhammadbabarkhawar adecadeofmightylipophagywhatweknowandwhatfactsweneedtoknow AT muddasirhassanabbasi adecadeofmightylipophagywhatweknowandwhatfactsweneedtoknow AT mussaratrafiq adecadeofmightylipophagywhatweknowandwhatfactsweneedtoknow AT nailanaz adecadeofmightylipophagywhatweknowandwhatfactsweneedtoknow AT rabiamehmood adecadeofmightylipophagywhatweknowandwhatfactsweneedtoknow AT nadeemsheikh adecadeofmightylipophagywhatweknowandwhatfactsweneedtoknow AT muhammadbabarkhawar decadeofmightylipophagywhatweknowandwhatfactsweneedtoknow AT muddasirhassanabbasi decadeofmightylipophagywhatweknowandwhatfactsweneedtoknow AT mussaratrafiq decadeofmightylipophagywhatweknowandwhatfactsweneedtoknow AT nailanaz decadeofmightylipophagywhatweknowandwhatfactsweneedtoknow AT rabiamehmood decadeofmightylipophagywhatweknowandwhatfactsweneedtoknow AT nadeemsheikh decadeofmightylipophagywhatweknowandwhatfactsweneedtoknow
_version_	1718428926882086912

A Decade of Mighty Lipophagy: What We Know and What Facts We Need to Know?

Ejemplares similares