The long non coding RNA H19 as a biomarker for breast cancer diagnosis in Lebanese women

Abstract Breast cancer is the most common cancer in women worldwide. Minimally invasive percutaneous image-guided biopsies are the current cornerstone in the diagnosis of breast lesions detected on mammography/ultrasonography/MRI or palpable clinically. However, apparently benign breast disease seen...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Tamina Elias-Rizk, Joelle El Hajj, Evelyne Segal-Bendirdjian, George Hilal
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/67238519ab334ff8b0170e0108523106
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:67238519ab334ff8b0170e0108523106
record_format	dspace
spelling	oai:doaj.org-article:67238519ab334ff8b0170e01085231062021-12-02T13:34:09ZThe long non coding RNA H19 as a biomarker for breast cancer diagnosis in Lebanese women10.1038/s41598-020-79285-z2045-2322https://doaj.org/article/67238519ab334ff8b0170e01085231062020-12-01T00:00:00Zhttps://doi.org/10.1038/s41598-020-79285-zhttps://doaj.org/toc/2045-2322Abstract Breast cancer is the most common cancer in women worldwide. Minimally invasive percutaneous image-guided biopsies are the current cornerstone in the diagnosis of breast lesions detected on mammography/ultrasonography/MRI or palpable clinically. However, apparently benign breast disease seen on benign biopsies is a limiting factor for diagnosis and a risk factor of breast cancer especially in the high-risk category patients. Hypothesizing that molecular changes often occur before morphological variations, the levels of the LncRNA H19 were measured in anonymous tissues obtained from 79 women’s image guided breast biopsies, and correlated with cancer progression and aggressiveness. Using a double-blinded approach, H19 might be attributed an interesting role of a more sensitive biomarker in core breast biopsies, independently of the radiological/clinical classification and distant from the clinical management. We established different thresholds for H19 levels in normal versus proliferative, versus malignant tissues. Additionnally, H19 could act as an intra-group risk marker categorizing the biopsies in normal versus benign, versus precancerous breast tissue, and as a prognostic factor in cancerous lesions discriminating aggressive versus nonaggressive lesions. Our study suggests that the lncRNA H19 could be a potential marker for breast cancer diagnosis, prognosis and risk management.Tamina Elias-RizkJoelle El HajjEvelyne Segal-BendirdjianGeorge HilalNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 10, Iss 1, Pp 1-7 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Tamina Elias-Rizk Joelle El Hajj Evelyne Segal-Bendirdjian George Hilal The long non coding RNA H19 as a biomarker for breast cancer diagnosis in Lebanese women
description	Abstract Breast cancer is the most common cancer in women worldwide. Minimally invasive percutaneous image-guided biopsies are the current cornerstone in the diagnosis of breast lesions detected on mammography/ultrasonography/MRI or palpable clinically. However, apparently benign breast disease seen on benign biopsies is a limiting factor for diagnosis and a risk factor of breast cancer especially in the high-risk category patients. Hypothesizing that molecular changes often occur before morphological variations, the levels of the LncRNA H19 were measured in anonymous tissues obtained from 79 women’s image guided breast biopsies, and correlated with cancer progression and aggressiveness. Using a double-blinded approach, H19 might be attributed an interesting role of a more sensitive biomarker in core breast biopsies, independently of the radiological/clinical classification and distant from the clinical management. We established different thresholds for H19 levels in normal versus proliferative, versus malignant tissues. Additionnally, H19 could act as an intra-group risk marker categorizing the biopsies in normal versus benign, versus precancerous breast tissue, and as a prognostic factor in cancerous lesions discriminating aggressive versus nonaggressive lesions. Our study suggests that the lncRNA H19 could be a potential marker for breast cancer diagnosis, prognosis and risk management.
format	article
author	Tamina Elias-Rizk Joelle El Hajj Evelyne Segal-Bendirdjian George Hilal
author_facet	Tamina Elias-Rizk Joelle El Hajj Evelyne Segal-Bendirdjian George Hilal
author_sort	Tamina Elias-Rizk
title	The long non coding RNA H19 as a biomarker for breast cancer diagnosis in Lebanese women
title_short	The long non coding RNA H19 as a biomarker for breast cancer diagnosis in Lebanese women
title_full	The long non coding RNA H19 as a biomarker for breast cancer diagnosis in Lebanese women
title_fullStr	The long non coding RNA H19 as a biomarker for breast cancer diagnosis in Lebanese women
title_full_unstemmed	The long non coding RNA H19 as a biomarker for breast cancer diagnosis in Lebanese women
title_sort	long non coding rna h19 as a biomarker for breast cancer diagnosis in lebanese women
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/67238519ab334ff8b0170e0108523106
work_keys_str_mv	AT taminaeliasrizk thelongnoncodingrnah19asabiomarkerforbreastcancerdiagnosisinlebanesewomen AT joelleelhajj thelongnoncodingrnah19asabiomarkerforbreastcancerdiagnosisinlebanesewomen AT evelynesegalbendirdjian thelongnoncodingrnah19asabiomarkerforbreastcancerdiagnosisinlebanesewomen AT georgehilal thelongnoncodingrnah19asabiomarkerforbreastcancerdiagnosisinlebanesewomen AT taminaeliasrizk longnoncodingrnah19asabiomarkerforbreastcancerdiagnosisinlebanesewomen AT joelleelhajj longnoncodingrnah19asabiomarkerforbreastcancerdiagnosisinlebanesewomen AT evelynesegalbendirdjian longnoncodingrnah19asabiomarkerforbreastcancerdiagnosisinlebanesewomen AT georgehilal longnoncodingrnah19asabiomarkerforbreastcancerdiagnosisinlebanesewomen
_version_	1718392799868485632

The long non coding RNA H19 as a biomarker for breast cancer diagnosis in Lebanese women

Ejemplares similares