Resveratrol against 6-OHDA-induced damage of PC12 cells via PI3K/Akt
Our previous in vivo study found that resveratrol (Res), which is a phytoalexin, attenuated 6-hydroxydopamine (6-OHDA)-induced motor dysfunction by activating the phosphatidylinositol 3-kinase/protein kinase B (PI3K/Akt) signaling pathway in rats. Therefore, we further explored the protective effect...
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De Gruyter
2021
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oai:doaj.org-article:67283ab2e39047b8a7593ea801ba4bcc2021-12-05T14:11:05ZResveratrol against 6-OHDA-induced damage of PC12 cells via PI3K/Akt2081-693610.1515/tnsci-2020-0165https://doaj.org/article/67283ab2e39047b8a7593ea801ba4bcc2021-04-01T00:00:00Zhttps://doi.org/10.1515/tnsci-2020-0165https://doaj.org/toc/2081-6936Our previous in vivo study found that resveratrol (Res), which is a phytoalexin, attenuated 6-hydroxydopamine (6-OHDA)-induced motor dysfunction by activating the phosphatidylinositol 3-kinase/protein kinase B (PI3K/Akt) signaling pathway in rats. Therefore, we further explored the protective effect of Res on 6-OHDA-induced damage to PC12 cells in vitro with respect to the PI3K/Akt signaling pathway.Huang NanquHuang JuanZhang YingChen MingjiShi JingshanJin FengDe Gruyterarticle6-hydroxydopamineresveratrolphosphoinositide 3-kinaseparkinson’s diseaseprotein kinase bNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571ENTranslational Neuroscience, Vol 12, Iss 1, Pp 138-144 (2021) |
institution |
DOAJ |
collection |
DOAJ |
language |
EN |
topic |
6-hydroxydopamine resveratrol phosphoinositide 3-kinase parkinson’s disease protein kinase b Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 |
spellingShingle |
6-hydroxydopamine resveratrol phosphoinositide 3-kinase parkinson’s disease protein kinase b Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Huang Nanqu Huang Juan Zhang Ying Chen Mingji Shi Jingshan Jin Feng Resveratrol against 6-OHDA-induced damage of PC12 cells via PI3K/Akt |
description |
Our previous in vivo study found that resveratrol (Res), which is a phytoalexin, attenuated 6-hydroxydopamine (6-OHDA)-induced motor dysfunction by activating the phosphatidylinositol 3-kinase/protein kinase B (PI3K/Akt) signaling pathway in rats. Therefore, we further explored the protective effect of Res on 6-OHDA-induced damage to PC12 cells in vitro with respect to the PI3K/Akt signaling pathway. |
format |
article |
author |
Huang Nanqu Huang Juan Zhang Ying Chen Mingji Shi Jingshan Jin Feng |
author_facet |
Huang Nanqu Huang Juan Zhang Ying Chen Mingji Shi Jingshan Jin Feng |
author_sort |
Huang Nanqu |
title |
Resveratrol against 6-OHDA-induced damage of PC12 cells via PI3K/Akt |
title_short |
Resveratrol against 6-OHDA-induced damage of PC12 cells via PI3K/Akt |
title_full |
Resveratrol against 6-OHDA-induced damage of PC12 cells via PI3K/Akt |
title_fullStr |
Resveratrol against 6-OHDA-induced damage of PC12 cells via PI3K/Akt |
title_full_unstemmed |
Resveratrol against 6-OHDA-induced damage of PC12 cells via PI3K/Akt |
title_sort |
resveratrol against 6-ohda-induced damage of pc12 cells via pi3k/akt |
publisher |
De Gruyter |
publishDate |
2021 |
url |
https://doaj.org/article/67283ab2e39047b8a7593ea801ba4bcc |
work_keys_str_mv |
AT huangnanqu resveratrolagainst6ohdainduceddamageofpc12cellsviapi3kakt AT huangjuan resveratrolagainst6ohdainduceddamageofpc12cellsviapi3kakt AT zhangying resveratrolagainst6ohdainduceddamageofpc12cellsviapi3kakt AT chenmingji resveratrolagainst6ohdainduceddamageofpc12cellsviapi3kakt AT shijingshan resveratrolagainst6ohdainduceddamageofpc12cellsviapi3kakt AT jinfeng resveratrolagainst6ohdainduceddamageofpc12cellsviapi3kakt |
_version_ |
1718371425633435648 |