Resveratrol against 6-OHDA-induced damage of PC12 cells via PI3K/Akt

Our previous in vivo study found that resveratrol (Res), which is a phytoalexin, attenuated 6-hydroxydopamine (6-OHDA)-induced motor dysfunction by activating the phosphatidylinositol 3-kinase/protein kinase B (PI3K/Akt) signaling pathway in rats. Therefore, we further explored the protective effect...

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Autores principales: Huang Nanqu, Huang Juan, Zhang Ying, Chen Mingji, Shi Jingshan, Jin Feng
Formato: article
Lenguaje:EN
Publicado: De Gruyter 2021
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Acceso en línea:https://doaj.org/article/67283ab2e39047b8a7593ea801ba4bcc
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spelling oai:doaj.org-article:67283ab2e39047b8a7593ea801ba4bcc2021-12-05T14:11:05ZResveratrol against 6-OHDA-induced damage of PC12 cells via PI3K/Akt2081-693610.1515/tnsci-2020-0165https://doaj.org/article/67283ab2e39047b8a7593ea801ba4bcc2021-04-01T00:00:00Zhttps://doi.org/10.1515/tnsci-2020-0165https://doaj.org/toc/2081-6936Our previous in vivo study found that resveratrol (Res), which is a phytoalexin, attenuated 6-hydroxydopamine (6-OHDA)-induced motor dysfunction by activating the phosphatidylinositol 3-kinase/protein kinase B (PI3K/Akt) signaling pathway in rats. Therefore, we further explored the protective effect of Res on 6-OHDA-induced damage to PC12 cells in vitro with respect to the PI3K/Akt signaling pathway.Huang NanquHuang JuanZhang YingChen MingjiShi JingshanJin FengDe Gruyterarticle6-hydroxydopamineresveratrolphosphoinositide 3-kinaseparkinson’s diseaseprotein kinase bNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571ENTranslational Neuroscience, Vol 12, Iss 1, Pp 138-144 (2021)
institution DOAJ
collection DOAJ
language EN
topic 6-hydroxydopamine
resveratrol
phosphoinositide 3-kinase
parkinson’s disease
protein kinase b
Neurosciences. Biological psychiatry. Neuropsychiatry
RC321-571
spellingShingle 6-hydroxydopamine
resveratrol
phosphoinositide 3-kinase
parkinson’s disease
protein kinase b
Neurosciences. Biological psychiatry. Neuropsychiatry
RC321-571
Huang Nanqu
Huang Juan
Zhang Ying
Chen Mingji
Shi Jingshan
Jin Feng
Resveratrol against 6-OHDA-induced damage of PC12 cells via PI3K/Akt
description Our previous in vivo study found that resveratrol (Res), which is a phytoalexin, attenuated 6-hydroxydopamine (6-OHDA)-induced motor dysfunction by activating the phosphatidylinositol 3-kinase/protein kinase B (PI3K/Akt) signaling pathway in rats. Therefore, we further explored the protective effect of Res on 6-OHDA-induced damage to PC12 cells in vitro with respect to the PI3K/Akt signaling pathway.
format article
author Huang Nanqu
Huang Juan
Zhang Ying
Chen Mingji
Shi Jingshan
Jin Feng
author_facet Huang Nanqu
Huang Juan
Zhang Ying
Chen Mingji
Shi Jingshan
Jin Feng
author_sort Huang Nanqu
title Resveratrol against 6-OHDA-induced damage of PC12 cells via PI3K/Akt
title_short Resveratrol against 6-OHDA-induced damage of PC12 cells via PI3K/Akt
title_full Resveratrol against 6-OHDA-induced damage of PC12 cells via PI3K/Akt
title_fullStr Resveratrol against 6-OHDA-induced damage of PC12 cells via PI3K/Akt
title_full_unstemmed Resveratrol against 6-OHDA-induced damage of PC12 cells via PI3K/Akt
title_sort resveratrol against 6-ohda-induced damage of pc12 cells via pi3k/akt
publisher De Gruyter
publishDate 2021
url https://doaj.org/article/67283ab2e39047b8a7593ea801ba4bcc
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AT huangjuan resveratrolagainst6ohdainduceddamageofpc12cellsviapi3kakt
AT zhangying resveratrolagainst6ohdainduceddamageofpc12cellsviapi3kakt
AT chenmingji resveratrolagainst6ohdainduceddamageofpc12cellsviapi3kakt
AT shijingshan resveratrolagainst6ohdainduceddamageofpc12cellsviapi3kakt
AT jinfeng resveratrolagainst6ohdainduceddamageofpc12cellsviapi3kakt
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