DNA methylation at enhancers identifies distinct breast cancer lineages

Breast cancers are classified based on gene expression profiles but it is well known that DNA methylation patterns are also altered. Here the authors, by combining genome-wide DNA methylation and gene expression analysis, identify transcriptional networks regulated by DNA methylation at enhancers ab...

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Autores principales:	Thomas Fleischer, Xavier Tekpli, Anthony Mathelier, Shixiong Wang, Daniel Nebdal, Hari P. Dhakal, Kristine Kleivi Sahlberg, Ellen Schlichting, Oslo Breast Cancer Research Consortium (OSBREAC), Anne-Lise Børresen-Dale, Elin Borgen, Bjørn Naume, Ragnhild Eskeland, Arnoldo Frigessi, Jörg Tost, Antoni Hurtado, Vessela N. Kristensen
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/672c1ec295c94bbb9950c3781c1429a7
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spelling	oai:doaj.org-article:672c1ec295c94bbb9950c3781c1429a72021-12-02T14:40:45ZDNA methylation at enhancers identifies distinct breast cancer lineages10.1038/s41467-017-00510-x2041-1723https://doaj.org/article/672c1ec295c94bbb9950c3781c1429a72017-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-00510-xhttps://doaj.org/toc/2041-1723Breast cancers are classified based on gene expression profiles but it is well known that DNA methylation patterns are also altered. Here the authors, by combining genome-wide DNA methylation and gene expression analysis, identify transcriptional networks regulated by DNA methylation at enhancers able to separate specific breast cancer subtypes.Thomas FleischerXavier TekpliAnthony MathelierShixiong WangDaniel NebdalHari P. DhakalKristine Kleivi SahlbergEllen SchlichtingOslo Breast Cancer Research Consortium (OSBREAC)Anne-Lise Børresen-DaleElin BorgenBjørn NaumeRagnhild EskelandArnoldo FrigessiJörg TostAntoni HurtadoVessela N. KristensenNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-14 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Thomas Fleischer Xavier Tekpli Anthony Mathelier Shixiong Wang Daniel Nebdal Hari P. Dhakal Kristine Kleivi Sahlberg Ellen Schlichting Oslo Breast Cancer Research Consortium (OSBREAC) Anne-Lise Børresen-Dale Elin Borgen Bjørn Naume Ragnhild Eskeland Arnoldo Frigessi Jörg Tost Antoni Hurtado Vessela N. Kristensen DNA methylation at enhancers identifies distinct breast cancer lineages
description	Breast cancers are classified based on gene expression profiles but it is well known that DNA methylation patterns are also altered. Here the authors, by combining genome-wide DNA methylation and gene expression analysis, identify transcriptional networks regulated by DNA methylation at enhancers able to separate specific breast cancer subtypes.
format	article
author	Thomas Fleischer Xavier Tekpli Anthony Mathelier Shixiong Wang Daniel Nebdal Hari P. Dhakal Kristine Kleivi Sahlberg Ellen Schlichting Oslo Breast Cancer Research Consortium (OSBREAC) Anne-Lise Børresen-Dale Elin Borgen Bjørn Naume Ragnhild Eskeland Arnoldo Frigessi Jörg Tost Antoni Hurtado Vessela N. Kristensen
author_facet	Thomas Fleischer Xavier Tekpli Anthony Mathelier Shixiong Wang Daniel Nebdal Hari P. Dhakal Kristine Kleivi Sahlberg Ellen Schlichting Oslo Breast Cancer Research Consortium (OSBREAC) Anne-Lise Børresen-Dale Elin Borgen Bjørn Naume Ragnhild Eskeland Arnoldo Frigessi Jörg Tost Antoni Hurtado Vessela N. Kristensen
author_sort	Thomas Fleischer
title	DNA methylation at enhancers identifies distinct breast cancer lineages
title_short	DNA methylation at enhancers identifies distinct breast cancer lineages
title_full	DNA methylation at enhancers identifies distinct breast cancer lineages
title_fullStr	DNA methylation at enhancers identifies distinct breast cancer lineages
title_full_unstemmed	DNA methylation at enhancers identifies distinct breast cancer lineages
title_sort	dna methylation at enhancers identifies distinct breast cancer lineages
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/672c1ec295c94bbb9950c3781c1429a7
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DNA methylation at enhancers identifies distinct breast cancer lineages

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