Recruitment of Cln3 cyclin to promoters controls cell cycle entry via histone deacetylase and other targets.

In yeast, the G1 cyclin Cln3 promotes cell cycle entry by activating the transcription factor SBF. In mammals, there is a parallel system for cell cycle entry in which cyclin dependent kinase (CDK) activates transcription factor E2F/Dp. Here we show that Cln3 regulates SBF by at least two different...

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Autores principales:	Hongyin Wang, Lucas B Carey, Ying Cai, Herman Wijnen, Bruce Futcher
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2009
Materias:	Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/672c3d4978ac449fa0bea45244344a32
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spelling	oai:doaj.org-article:672c3d4978ac449fa0bea45244344a322021-11-25T05:34:33ZRecruitment of Cln3 cyclin to promoters controls cell cycle entry via histone deacetylase and other targets.1544-91731545-788510.1371/journal.pbio.1000189https://doaj.org/article/672c3d4978ac449fa0bea45244344a322009-09-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/19823669/?tool=EBIhttps://doaj.org/toc/1544-9173https://doaj.org/toc/1545-7885In yeast, the G1 cyclin Cln3 promotes cell cycle entry by activating the transcription factor SBF. In mammals, there is a parallel system for cell cycle entry in which cyclin dependent kinase (CDK) activates transcription factor E2F/Dp. Here we show that Cln3 regulates SBF by at least two different pathways, one involving the repressive protein Whi5, and the second involving Stb1. The Rpd3 histone deacetylase complex is also involved. Cln3 binds to SBF at the CLN2 promoter, and removes previously bound Whi5 and histone deacetylase. Adding extra copies of the SBF binding site to the cell delays Start, possibly by titrating Cln3. Since Rpd3 is the yeast ortholog of mammalian HDAC1, there is now a virtually complete analogy between the proteins regulating cell cycle entry in yeast (SBF, Cln3, Whi5 and Stb1, Rpd3) and mammals (E2F, Cyclin D, Rb, HDAC1). The cell may titrate Cln3 molecules against the number of SBF binding sites, and this could be the underlying basis of the size-control mechanism for Start.Hongyin WangLucas B CareyYing CaiHerman WijnenBruce FutcherPublic Library of Science (PLoS)articleBiology (General)QH301-705.5ENPLoS Biology, Vol 7, Iss 9, p e1000189 (2009)
institution	DOAJ
collection	DOAJ
language	EN
topic	Biology (General) QH301-705.5
spellingShingle	Biology (General) QH301-705.5 Hongyin Wang Lucas B Carey Ying Cai Herman Wijnen Bruce Futcher Recruitment of Cln3 cyclin to promoters controls cell cycle entry via histone deacetylase and other targets.
description	In yeast, the G1 cyclin Cln3 promotes cell cycle entry by activating the transcription factor SBF. In mammals, there is a parallel system for cell cycle entry in which cyclin dependent kinase (CDK) activates transcription factor E2F/Dp. Here we show that Cln3 regulates SBF by at least two different pathways, one involving the repressive protein Whi5, and the second involving Stb1. The Rpd3 histone deacetylase complex is also involved. Cln3 binds to SBF at the CLN2 promoter, and removes previously bound Whi5 and histone deacetylase. Adding extra copies of the SBF binding site to the cell delays Start, possibly by titrating Cln3. Since Rpd3 is the yeast ortholog of mammalian HDAC1, there is now a virtually complete analogy between the proteins regulating cell cycle entry in yeast (SBF, Cln3, Whi5 and Stb1, Rpd3) and mammals (E2F, Cyclin D, Rb, HDAC1). The cell may titrate Cln3 molecules against the number of SBF binding sites, and this could be the underlying basis of the size-control mechanism for Start.
format	article
author	Hongyin Wang Lucas B Carey Ying Cai Herman Wijnen Bruce Futcher
author_facet	Hongyin Wang Lucas B Carey Ying Cai Herman Wijnen Bruce Futcher
author_sort	Hongyin Wang
title	Recruitment of Cln3 cyclin to promoters controls cell cycle entry via histone deacetylase and other targets.
title_short	Recruitment of Cln3 cyclin to promoters controls cell cycle entry via histone deacetylase and other targets.
title_full	Recruitment of Cln3 cyclin to promoters controls cell cycle entry via histone deacetylase and other targets.
title_fullStr	Recruitment of Cln3 cyclin to promoters controls cell cycle entry via histone deacetylase and other targets.
title_full_unstemmed	Recruitment of Cln3 cyclin to promoters controls cell cycle entry via histone deacetylase and other targets.
title_sort	recruitment of cln3 cyclin to promoters controls cell cycle entry via histone deacetylase and other targets.
publisher	Public Library of Science (PLoS)
publishDate	2009
url	https://doaj.org/article/672c3d4978ac449fa0bea45244344a32
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Recruitment of Cln3 cyclin to promoters controls cell cycle entry via histone deacetylase and other targets.

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