De Ritis ratio (AST/ALT) as an independent predictor of poor outcome in patients with acute ischemic stroke

Fan Gao,1 Chen Chen,2 Jun Lu,1 Jie Zheng,1 Xian-Cang Ma,1,3 Xing-Yun Yuan,2 Kang Huo,2 Jian-Feng Han2 1Clinical Research Center, 2Department of Neurology, 3Department of Psychiatry, The First Affiliated Hospital of Xi’an Jiaotong University, Xi’an, Shaanxi, China Purpose: The a...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Gao F, Chen C, Lu J, Zheng J, Ma XC, Yuan XY, Huo K, Han JF
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2017
Materias:	De Ritis ratio stroke prognosis Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
Acceso en línea:	https://doaj.org/article/672c8e4c69534e37b25bdbb00380c16b
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:672c8e4c69534e37b25bdbb00380c16b
record_format	dspace
spelling	oai:doaj.org-article:672c8e4c69534e37b25bdbb00380c16b2021-12-02T06:09:00ZDe Ritis ratio (AST/ALT) as an independent predictor of poor outcome in patients with acute ischemic stroke1178-2021https://doaj.org/article/672c8e4c69534e37b25bdbb00380c16b2017-06-01T00:00:00Zhttps://www.dovepress.com/de-ritis-ratio-astalt-as-an-independent-predictor-of-poor-outcome-in-p-peer-reviewed-article-NDThttps://doaj.org/toc/1178-2021Fan Gao,1 Chen Chen,2 Jun Lu,1 Jie Zheng,1 Xian-Cang Ma,1,3 Xing-Yun Yuan,2 Kang Huo,2 Jian-Feng Han2 1Clinical Research Center, 2Department of Neurology, 3Department of Psychiatry, The First Affiliated Hospital of Xi’an Jiaotong University, Xi’an, Shaanxi, China Purpose: The aspartate transaminase/alanine transaminase ratio (De Ritis ratio, AAR) was reported to be associated with patients’ prognosis in certain diseases recently. The objective of the current study was to determine the association between the AAR at admission and poor outcome at 3 months in acute ischemic stroke (AIS) patients.Patients and methods: This retrospective cohort study included patients who experienced their first-ever AIS between June 2015 and March 2016. The primary outcome measure was a poor outcome at 3 months (modified Rankin Scale score >2). Multivariate logistic regression models were used to assess the relationship between AAR quartiles and clinical outcomes among the AIS patients. Receiver operating characteristic curve analysis was applied to identify the optimal cutoff for AAR in predicting the prognosis of AIS.Results: In terms of the relationship between poor outcome and AAR, the adjusted odds ratio comparing the highest and lowest AAR quartiles was 2.15 (95% confidence interval =1.14–4.05). An AAR of 1.53 was identified as the optimal cutoff. In a prespecified subgroup analysis according to the time from symptom onset to treatment (>24 vs ≤24 hours), there was no significant difference in the effect of AAR >1.53 between the two groups.Conclusion: An increased AAR at admission is significantly associated with a poor outcome at 3 months in AIS patients. Keywords: De Ritis ratio, stroke, prognosis, aspartate transaminase, alanine transaminase, modified Rankin scale, poor outcomeGao FChen CLu JZheng JMa XCYuan XYHuo KHan JFDove Medical PressarticleDe Ritis ratiostrokeprognosisNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571Neurology. Diseases of the nervous systemRC346-429ENNeuropsychiatric Disease and Treatment, Vol Volume 13, Pp 1551-1557 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	De Ritis ratio stroke prognosis Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
spellingShingle	De Ritis ratio stroke prognosis Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429 Gao F Chen C Lu J Zheng J Ma XC Yuan XY Huo K Han JF De Ritis ratio (AST/ALT) as an independent predictor of poor outcome in patients with acute ischemic stroke
description	Fan Gao,1 Chen Chen,2 Jun Lu,1 Jie Zheng,1 Xian-Cang Ma,1,3 Xing-Yun Yuan,2 Kang Huo,2 Jian-Feng Han2 1Clinical Research Center, 2Department of Neurology, 3Department of Psychiatry, The First Affiliated Hospital of Xi’an Jiaotong University, Xi’an, Shaanxi, China Purpose: The aspartate transaminase/alanine transaminase ratio (De Ritis ratio, AAR) was reported to be associated with patients’ prognosis in certain diseases recently. The objective of the current study was to determine the association between the AAR at admission and poor outcome at 3 months in acute ischemic stroke (AIS) patients.Patients and methods: This retrospective cohort study included patients who experienced their first-ever AIS between June 2015 and March 2016. The primary outcome measure was a poor outcome at 3 months (modified Rankin Scale score >2). Multivariate logistic regression models were used to assess the relationship between AAR quartiles and clinical outcomes among the AIS patients. Receiver operating characteristic curve analysis was applied to identify the optimal cutoff for AAR in predicting the prognosis of AIS.Results: In terms of the relationship between poor outcome and AAR, the adjusted odds ratio comparing the highest and lowest AAR quartiles was 2.15 (95% confidence interval =1.14–4.05). An AAR of 1.53 was identified as the optimal cutoff. In a prespecified subgroup analysis according to the time from symptom onset to treatment (>24 vs ≤24 hours), there was no significant difference in the effect of AAR >1.53 between the two groups.Conclusion: An increased AAR at admission is significantly associated with a poor outcome at 3 months in AIS patients. Keywords: De Ritis ratio, stroke, prognosis, aspartate transaminase, alanine transaminase, modified Rankin scale, poor outcome
format	article
author	Gao F Chen C Lu J Zheng J Ma XC Yuan XY Huo K Han JF
author_facet	Gao F Chen C Lu J Zheng J Ma XC Yuan XY Huo K Han JF
author_sort	Gao F
title	De Ritis ratio (AST/ALT) as an independent predictor of poor outcome in patients with acute ischemic stroke
title_short	De Ritis ratio (AST/ALT) as an independent predictor of poor outcome in patients with acute ischemic stroke
title_full	De Ritis ratio (AST/ALT) as an independent predictor of poor outcome in patients with acute ischemic stroke
title_fullStr	De Ritis ratio (AST/ALT) as an independent predictor of poor outcome in patients with acute ischemic stroke
title_full_unstemmed	De Ritis ratio (AST/ALT) as an independent predictor of poor outcome in patients with acute ischemic stroke
title_sort	de ritis ratio (ast/alt) as an independent predictor of poor outcome in patients with acute ischemic stroke
publisher	Dove Medical Press
publishDate	2017
url	https://doaj.org/article/672c8e4c69534e37b25bdbb00380c16b
work_keys_str_mv	AT gaof deritisratioastaltasanindependentpredictorofpooroutcomeinpatientswithacuteischemicstroke AT chenc deritisratioastaltasanindependentpredictorofpooroutcomeinpatientswithacuteischemicstroke AT luj deritisratioastaltasanindependentpredictorofpooroutcomeinpatientswithacuteischemicstroke AT zhengj deritisratioastaltasanindependentpredictorofpooroutcomeinpatientswithacuteischemicstroke AT maxc deritisratioastaltasanindependentpredictorofpooroutcomeinpatientswithacuteischemicstroke AT yuanxy deritisratioastaltasanindependentpredictorofpooroutcomeinpatientswithacuteischemicstroke AT huok deritisratioastaltasanindependentpredictorofpooroutcomeinpatientswithacuteischemicstroke AT hanjf deritisratioastaltasanindependentpredictorofpooroutcomeinpatientswithacuteischemicstroke
_version_	1718400054660694016

De Ritis ratio (AST/ALT) as an independent predictor of poor outcome in patients with acute ischemic stroke

Ejemplares similares