Mosaic deletion patterns of the human antibody heavy chain gene locus shown by Bayesian haplotyping

High-throughput sequencing and analyzes of antibody repertoire provide important information on immune responses, but current methodologies are limited in sequence assembly precision and haplotype inference validity. Here the authors propose a new Bayesian haplotyping method, and attest its broad ap...

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Autores principales:	Moriah Gidoni, Omri Snir, Ayelet Peres, Pazit Polak, Ida Lindeman, Ivana Mikocziova, Vikas Kumar Sarna, Knut E. A. Lundin, Christopher Clouser, Francois Vigneault, Andrew M. Collins, Ludvig M. Sollid, Gur Yaari
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/673286972274442fbf2f5824de7b4daa
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spelling	oai:doaj.org-article:673286972274442fbf2f5824de7b4daa2021-12-02T15:35:06ZMosaic deletion patterns of the human antibody heavy chain gene locus shown by Bayesian haplotyping10.1038/s41467-019-08489-32041-1723https://doaj.org/article/673286972274442fbf2f5824de7b4daa2019-02-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-08489-3https://doaj.org/toc/2041-1723High-throughput sequencing and analyzes of antibody repertoire provide important information on immune responses, but current methodologies are limited in sequence assembly precision and haplotype inference validity. Here the authors propose a new Bayesian haplotyping method, and attest its broad application with a large, multi-individual dataset.Moriah GidoniOmri SnirAyelet PeresPazit PolakIda LindemanIvana MikocziovaVikas Kumar SarnaKnut E. A. LundinChristopher ClouserFrancois VigneaultAndrew M. CollinsLudvig M. SollidGur YaariNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Moriah Gidoni Omri Snir Ayelet Peres Pazit Polak Ida Lindeman Ivana Mikocziova Vikas Kumar Sarna Knut E. A. Lundin Christopher Clouser Francois Vigneault Andrew M. Collins Ludvig M. Sollid Gur Yaari Mosaic deletion patterns of the human antibody heavy chain gene locus shown by Bayesian haplotyping
description	High-throughput sequencing and analyzes of antibody repertoire provide important information on immune responses, but current methodologies are limited in sequence assembly precision and haplotype inference validity. Here the authors propose a new Bayesian haplotyping method, and attest its broad application with a large, multi-individual dataset.
format	article
author	Moriah Gidoni Omri Snir Ayelet Peres Pazit Polak Ida Lindeman Ivana Mikocziova Vikas Kumar Sarna Knut E. A. Lundin Christopher Clouser Francois Vigneault Andrew M. Collins Ludvig M. Sollid Gur Yaari
author_facet	Moriah Gidoni Omri Snir Ayelet Peres Pazit Polak Ida Lindeman Ivana Mikocziova Vikas Kumar Sarna Knut E. A. Lundin Christopher Clouser Francois Vigneault Andrew M. Collins Ludvig M. Sollid Gur Yaari
author_sort	Moriah Gidoni
title	Mosaic deletion patterns of the human antibody heavy chain gene locus shown by Bayesian haplotyping
title_short	Mosaic deletion patterns of the human antibody heavy chain gene locus shown by Bayesian haplotyping
title_full	Mosaic deletion patterns of the human antibody heavy chain gene locus shown by Bayesian haplotyping
title_fullStr	Mosaic deletion patterns of the human antibody heavy chain gene locus shown by Bayesian haplotyping
title_full_unstemmed	Mosaic deletion patterns of the human antibody heavy chain gene locus shown by Bayesian haplotyping
title_sort	mosaic deletion patterns of the human antibody heavy chain gene locus shown by bayesian haplotyping
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/673286972274442fbf2f5824de7b4daa
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Mosaic deletion patterns of the human antibody heavy chain gene locus shown by Bayesian haplotyping

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