Manganese-Doped N-Hydroxyphthalimide-Derived Carbon Dots—Theranostics Applications in Experimental Breast Cancer Models

Background: Theranostics, a novel concept in medicine, is based on the use of an agent for simultaneous diagnosis and treatment. Nanomaterials provide promising novel approaches to theranostics. Carbon Dots have been shown to exhibit anti-tumoral properties in various cancer models. The aim of the p...

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Autores principales:	Adrian Tiron, Corneliu S. Stan, Gabriel Luta, Cristina M. Uritu, Irina-Cezara Vacarean-Trandafir, Gabriela D. Stanciu, Adina Coroaba, Crina E. Tiron
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	carbon dots anti-cancer MRI nanomedicine theranostic Pharmacy and materia medica RS1-441
Acceso en línea:	https://doaj.org/article/67366e954b194e2b846df790ee36d9d7
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spelling	oai:doaj.org-article:67366e954b194e2b846df790ee36d9d72021-11-25T18:42:48ZManganese-Doped N-Hydroxyphthalimide-Derived Carbon Dots—Theranostics Applications in Experimental Breast Cancer Models10.3390/pharmaceutics131119821999-4923https://doaj.org/article/67366e954b194e2b846df790ee36d9d72021-11-01T00:00:00Zhttps://www.mdpi.com/1999-4923/13/11/1982https://doaj.org/toc/1999-4923Background: Theranostics, a novel concept in medicine, is based on the use of an agent for simultaneous diagnosis and treatment. Nanomaterials provide promising novel approaches to theranostics. Carbon Dots have been shown to exhibit anti-tumoral properties in various cancer models. The aim of the present study is to develop gadolinium, Fe<sup>3+</sup>, and Mn<sup>2+</sup>-doped N-hydroxyphthalimide-derived Carbon Dots. The resulted doped Carbon Dots should preserve the anti-tumoral properties while gaining magnetic resonance imaging properties. Methods: Normal and cancer cell lines have been treated with doped Carbon Dots, and the cell viability has been measured. The doped Carbon Dots that exhibited the most prominent anti-tumoral effect accompanied by the lowest toxicity have been further in vivo tested. Magnetic resonance imaging evaluates both in vitro and in vivo the possibility of using doped Carbon Dots as a contrast agent. Results: According to the results obtained from both the in vitro and in vivo experimental models used in our study, Mn<sup>2+</sup>-doped Carbon Dots (Mn-CDs-NHF) exhibit anti-tumoral properties, do not significantly impair the cell viability of normal cells, and reduce lung metastasis and the volume of mammary primary tumors while allowing magnetic resonance imaging. Conclusions: Our findings prove that Mn-CDs-NHF can be used as theranostics agents in pre-clinical models.Adrian TironCorneliu S. StanGabriel LutaCristina M. UrituIrina-Cezara Vacarean-TrandafirGabriela D. StanciuAdina CoroabaCrina E. TironMDPI AGarticlecarbon dotsanti-cancerMRInanomedicinetheranosticPharmacy and materia medicaRS1-441ENPharmaceutics, Vol 13, Iss 1982, p 1982 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	carbon dots anti-cancer MRI nanomedicine theranostic Pharmacy and materia medica RS1-441
spellingShingle	carbon dots anti-cancer MRI nanomedicine theranostic Pharmacy and materia medica RS1-441 Adrian Tiron Corneliu S. Stan Gabriel Luta Cristina M. Uritu Irina-Cezara Vacarean-Trandafir Gabriela D. Stanciu Adina Coroaba Crina E. Tiron Manganese-Doped N-Hydroxyphthalimide-Derived Carbon Dots—Theranostics Applications in Experimental Breast Cancer Models
description	Background: Theranostics, a novel concept in medicine, is based on the use of an agent for simultaneous diagnosis and treatment. Nanomaterials provide promising novel approaches to theranostics. Carbon Dots have been shown to exhibit anti-tumoral properties in various cancer models. The aim of the present study is to develop gadolinium, Fe<sup>3+</sup>, and Mn<sup>2+</sup>-doped N-hydroxyphthalimide-derived Carbon Dots. The resulted doped Carbon Dots should preserve the anti-tumoral properties while gaining magnetic resonance imaging properties. Methods: Normal and cancer cell lines have been treated with doped Carbon Dots, and the cell viability has been measured. The doped Carbon Dots that exhibited the most prominent anti-tumoral effect accompanied by the lowest toxicity have been further in vivo tested. Magnetic resonance imaging evaluates both in vitro and in vivo the possibility of using doped Carbon Dots as a contrast agent. Results: According to the results obtained from both the in vitro and in vivo experimental models used in our study, Mn<sup>2+</sup>-doped Carbon Dots (Mn-CDs-NHF) exhibit anti-tumoral properties, do not significantly impair the cell viability of normal cells, and reduce lung metastasis and the volume of mammary primary tumors while allowing magnetic resonance imaging. Conclusions: Our findings prove that Mn-CDs-NHF can be used as theranostics agents in pre-clinical models.
format	article
author	Adrian Tiron Corneliu S. Stan Gabriel Luta Cristina M. Uritu Irina-Cezara Vacarean-Trandafir Gabriela D. Stanciu Adina Coroaba Crina E. Tiron
author_facet	Adrian Tiron Corneliu S. Stan Gabriel Luta Cristina M. Uritu Irina-Cezara Vacarean-Trandafir Gabriela D. Stanciu Adina Coroaba Crina E. Tiron
author_sort	Adrian Tiron
title	Manganese-Doped N-Hydroxyphthalimide-Derived Carbon Dots—Theranostics Applications in Experimental Breast Cancer Models
title_short	Manganese-Doped N-Hydroxyphthalimide-Derived Carbon Dots—Theranostics Applications in Experimental Breast Cancer Models
title_full	Manganese-Doped N-Hydroxyphthalimide-Derived Carbon Dots—Theranostics Applications in Experimental Breast Cancer Models
title_fullStr	Manganese-Doped N-Hydroxyphthalimide-Derived Carbon Dots—Theranostics Applications in Experimental Breast Cancer Models
title_full_unstemmed	Manganese-Doped N-Hydroxyphthalimide-Derived Carbon Dots—Theranostics Applications in Experimental Breast Cancer Models
title_sort	manganese-doped n-hydroxyphthalimide-derived carbon dots—theranostics applications in experimental breast cancer models
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/67366e954b194e2b846df790ee36d9d7
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Manganese-Doped N-Hydroxyphthalimide-Derived Carbon Dots—Theranostics Applications in Experimental Breast Cancer Models

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