Hematological Abnormalities of Adult HIV-Infected Patients Before and After Initiation of Highly Active Antiretroviral Treatment at Debre Tabor Comprehensive Specialized Hospital, Northcentral Ethiopia: A Cross-Sectional Study

Shewaneh Damtie, Lemma Workineh, Teklehaimanot Kiros, Tahir Eyayu, Tegenaw Tiruneh Debre Tabor University, College of Health Sciences, Department of Medical Laboratory Science, Debre Tabor, EthiopiaCorrespondence: Shewaneh DamtieDebre Tabor University, College of Health Sciences, Department of Medic...

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Autores principales:	Damtie S, Workineh L, Kiros T, Eyayu T, Tiruneh T
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2021
Materias:	hiv anemia leucopenia thrombocytopenia haart Immunologic diseases. Allergy RC581-607
Acceso en línea:	https://doaj.org/article/6739aec68fcc4c9b91ebdcf88656be2f
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spelling	oai:doaj.org-article:6739aec68fcc4c9b91ebdcf88656be2f2021-12-02T15:20:04ZHematological Abnormalities of Adult HIV-Infected Patients Before and After Initiation of Highly Active Antiretroviral Treatment at Debre Tabor Comprehensive Specialized Hospital, Northcentral Ethiopia: A Cross-Sectional Study1179-1373https://doaj.org/article/6739aec68fcc4c9b91ebdcf88656be2f2021-05-01T00:00:00Zhttps://www.dovepress.com/hematological-abnormalities-of-adult-hiv-infected-patients-before-and--peer-reviewed-fulltext-article-HIVhttps://doaj.org/toc/1179-1373Shewaneh Damtie, Lemma Workineh, Teklehaimanot Kiros, Tahir Eyayu, Tegenaw Tiruneh Debre Tabor University, College of Health Sciences, Department of Medical Laboratory Science, Debre Tabor, EthiopiaCorrespondence: Shewaneh DamtieDebre Tabor University, College of Health Sciences, Department of Medical Laboratory Science, Debre Tabor, EthiopiaTel +251 918735194Email yeshiworkazene@yahoo.comBackground: Hematological abnormalities have been associated with an increased risk of disease progression and death in people living with human immunodeficiency virus (HIV). The use of antiretroviral medications can have a positive or negative effect on the hematological disorder. However, little is known about its impact on hematological parameters in antiretroviral-treated patients in Ethiopia, especially in the study area.Methods: A cross-sectional study was conducted at Debre Tabor Comprehensive Specialized Hospital from September to November 2020. A total of 334 HIV-infected patients taking highly active antiretroviral treatment (HAART) at least for 6 months were selected using a simple random sampling technique. Socio-demographic and clinical characteristics of the study subjects were collected using a semi-structured questionnaire. Hematological and immunological parameters were determined using Sysmex kx-21 hematology analyzer and BD FACS count CD4 analyzer, respectively. Statistical analysis was done using SPSS version 20 statistical software. A P-value < 0.05 was considered statistically significant.Results: A total of 334 HIV patients were included in this study. The prevalence of anemia, leucopenia, neutropenia, lymphopenia and thrombocytopenia were 37.1%, 22.8%, 8.4%, 10.5% and 17.1% before initiation of HAART and 17.4%, 34.2%, 18.8%, 13.1% and 8.3% after initiation of HAART, respectively. There was a significant difference in total white blood cell (WBC) count, absolute neutrophil count (ANC), red blood cell (RBC) count, hemoglobin value, mean cell volume (MCV), mean cell hemoglobin (MCH), mean cell hemoglobin concentration (MCHC), red cell distribution width (RDW), platelet and CD4+ T cell counts in HIV patients before and after initiation of HAART (P< 0.05).Conclusion: The most common hematological abnormalities observed in this study before and after HAART initiation were anemia, leucopenia, neutropenia, lymphopenia, and thrombocytopenia. However, after beginning HAART, the prevalence of anemia and thrombocytopenia decreased dramatically.Keywords: HIV, anemia, leucopenia, thrombocytopenia, HAARTDamtie SWorkineh LKiros TEyayu TTiruneh TDove Medical PressarticlehivanemialeucopeniathrombocytopeniahaartImmunologic diseases. AllergyRC581-607ENHIV/AIDS: Research and Palliative Care, Vol Volume 13, Pp 477-484 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	hiv anemia leucopenia thrombocytopenia haart Immunologic diseases. Allergy RC581-607
spellingShingle	hiv anemia leucopenia thrombocytopenia haart Immunologic diseases. Allergy RC581-607 Damtie S Workineh L Kiros T Eyayu T Tiruneh T Hematological Abnormalities of Adult HIV-Infected Patients Before and After Initiation of Highly Active Antiretroviral Treatment at Debre Tabor Comprehensive Specialized Hospital, Northcentral Ethiopia: A Cross-Sectional Study
description	Shewaneh Damtie, Lemma Workineh, Teklehaimanot Kiros, Tahir Eyayu, Tegenaw Tiruneh Debre Tabor University, College of Health Sciences, Department of Medical Laboratory Science, Debre Tabor, EthiopiaCorrespondence: Shewaneh DamtieDebre Tabor University, College of Health Sciences, Department of Medical Laboratory Science, Debre Tabor, EthiopiaTel +251 918735194Email yeshiworkazene@yahoo.comBackground: Hematological abnormalities have been associated with an increased risk of disease progression and death in people living with human immunodeficiency virus (HIV). The use of antiretroviral medications can have a positive or negative effect on the hematological disorder. However, little is known about its impact on hematological parameters in antiretroviral-treated patients in Ethiopia, especially in the study area.Methods: A cross-sectional study was conducted at Debre Tabor Comprehensive Specialized Hospital from September to November 2020. A total of 334 HIV-infected patients taking highly active antiretroviral treatment (HAART) at least for 6 months were selected using a simple random sampling technique. Socio-demographic and clinical characteristics of the study subjects were collected using a semi-structured questionnaire. Hematological and immunological parameters were determined using Sysmex kx-21 hematology analyzer and BD FACS count CD4 analyzer, respectively. Statistical analysis was done using SPSS version 20 statistical software. A P-value < 0.05 was considered statistically significant.Results: A total of 334 HIV patients were included in this study. The prevalence of anemia, leucopenia, neutropenia, lymphopenia and thrombocytopenia were 37.1%, 22.8%, 8.4%, 10.5% and 17.1% before initiation of HAART and 17.4%, 34.2%, 18.8%, 13.1% and 8.3% after initiation of HAART, respectively. There was a significant difference in total white blood cell (WBC) count, absolute neutrophil count (ANC), red blood cell (RBC) count, hemoglobin value, mean cell volume (MCV), mean cell hemoglobin (MCH), mean cell hemoglobin concentration (MCHC), red cell distribution width (RDW), platelet and CD4+ T cell counts in HIV patients before and after initiation of HAART (P< 0.05).Conclusion: The most common hematological abnormalities observed in this study before and after HAART initiation were anemia, leucopenia, neutropenia, lymphopenia, and thrombocytopenia. However, after beginning HAART, the prevalence of anemia and thrombocytopenia decreased dramatically.Keywords: HIV, anemia, leucopenia, thrombocytopenia, HAART
format	article
author	Damtie S Workineh L Kiros T Eyayu T Tiruneh T
author_facet	Damtie S Workineh L Kiros T Eyayu T Tiruneh T
author_sort	Damtie S
title	Hematological Abnormalities of Adult HIV-Infected Patients Before and After Initiation of Highly Active Antiretroviral Treatment at Debre Tabor Comprehensive Specialized Hospital, Northcentral Ethiopia: A Cross-Sectional Study
title_short	Hematological Abnormalities of Adult HIV-Infected Patients Before and After Initiation of Highly Active Antiretroviral Treatment at Debre Tabor Comprehensive Specialized Hospital, Northcentral Ethiopia: A Cross-Sectional Study
title_full	Hematological Abnormalities of Adult HIV-Infected Patients Before and After Initiation of Highly Active Antiretroviral Treatment at Debre Tabor Comprehensive Specialized Hospital, Northcentral Ethiopia: A Cross-Sectional Study
title_fullStr	Hematological Abnormalities of Adult HIV-Infected Patients Before and After Initiation of Highly Active Antiretroviral Treatment at Debre Tabor Comprehensive Specialized Hospital, Northcentral Ethiopia: A Cross-Sectional Study
title_full_unstemmed	Hematological Abnormalities of Adult HIV-Infected Patients Before and After Initiation of Highly Active Antiretroviral Treatment at Debre Tabor Comprehensive Specialized Hospital, Northcentral Ethiopia: A Cross-Sectional Study
title_sort	hematological abnormalities of adult hiv-infected patients before and after initiation of highly active antiretroviral treatment at debre tabor comprehensive specialized hospital, northcentral ethiopia: a cross-sectional study
publisher	Dove Medical Press
publishDate	2021
url	https://doaj.org/article/6739aec68fcc4c9b91ebdcf88656be2f
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Hematological Abnormalities of Adult HIV-Infected Patients Before and After Initiation of Highly Active Antiretroviral Treatment at Debre Tabor Comprehensive Specialized Hospital, Northcentral Ethiopia: A Cross-Sectional Study

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