Orexinergic descending inhibitory pathway mediates linalool odor-induced analgesia in mice

Abstract Linalool odor exposure induces an analgesic effect in mice. This effect disappeared in the anosmic model mice, indicating that olfactory input evoked by linalool odor triggered this effect. Furthermore, hypothalamic orexinergic neurons play a pivotal role in this effect. However, the neuron...

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Autores principales:	Yurina Higa, Hideki Kashiwadani, Mitsutaka Sugimura, Tomoyuki Kuwaki
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/673b3c0670f2485484880dfedd516320
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spelling	oai:doaj.org-article:673b3c0670f2485484880dfedd5163202021-12-02T16:55:34ZOrexinergic descending inhibitory pathway mediates linalool odor-induced analgesia in mice10.1038/s41598-021-88359-52045-2322https://doaj.org/article/673b3c0670f2485484880dfedd5163202021-04-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-88359-5https://doaj.org/toc/2045-2322Abstract Linalool odor exposure induces an analgesic effect in mice. This effect disappeared in the anosmic model mice, indicating that olfactory input evoked by linalool odor triggered this effect. Furthermore, hypothalamic orexinergic neurons play a pivotal role in this effect. However, the neuronal circuit mechanisms underlying this effect have not been fully addressed. In this study, we focused on the descending orexinergic projection to the spinal cord and examined whether this pathway contributes to the effect. We assessed the effect of intrathecal administration of orexin receptor antagonists on linalool odor-induced analgesia in the tail capsaicin test. We found that the selective orexin type 1 receptor antagonist, but not the selective orexin type 2 receptor antagonist, prevented the odor-induced analgesic effect. Furthermore, immunohistochemical analyses of c-Fos expression induced by the capsaicin test revealed that neuronal activity of spinal cord neurons was suppressed by linalool odor exposure, which was prevented by intrathecal administration of the orexin 1 receptor antagonist. These results indicate that linalool odor exposure drives the orexinergic descending pathway and suppresses nociceptive information flow at the spinal level.Yurina HigaHideki KashiwadaniMitsutaka SugimuraTomoyuki KuwakiNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Yurina Higa Hideki Kashiwadani Mitsutaka Sugimura Tomoyuki Kuwaki Orexinergic descending inhibitory pathway mediates linalool odor-induced analgesia in mice
description	Abstract Linalool odor exposure induces an analgesic effect in mice. This effect disappeared in the anosmic model mice, indicating that olfactory input evoked by linalool odor triggered this effect. Furthermore, hypothalamic orexinergic neurons play a pivotal role in this effect. However, the neuronal circuit mechanisms underlying this effect have not been fully addressed. In this study, we focused on the descending orexinergic projection to the spinal cord and examined whether this pathway contributes to the effect. We assessed the effect of intrathecal administration of orexin receptor antagonists on linalool odor-induced analgesia in the tail capsaicin test. We found that the selective orexin type 1 receptor antagonist, but not the selective orexin type 2 receptor antagonist, prevented the odor-induced analgesic effect. Furthermore, immunohistochemical analyses of c-Fos expression induced by the capsaicin test revealed that neuronal activity of spinal cord neurons was suppressed by linalool odor exposure, which was prevented by intrathecal administration of the orexin 1 receptor antagonist. These results indicate that linalool odor exposure drives the orexinergic descending pathway and suppresses nociceptive information flow at the spinal level.
format	article
author	Yurina Higa Hideki Kashiwadani Mitsutaka Sugimura Tomoyuki Kuwaki
author_facet	Yurina Higa Hideki Kashiwadani Mitsutaka Sugimura Tomoyuki Kuwaki
author_sort	Yurina Higa
title	Orexinergic descending inhibitory pathway mediates linalool odor-induced analgesia in mice
title_short	Orexinergic descending inhibitory pathway mediates linalool odor-induced analgesia in mice
title_full	Orexinergic descending inhibitory pathway mediates linalool odor-induced analgesia in mice
title_fullStr	Orexinergic descending inhibitory pathway mediates linalool odor-induced analgesia in mice
title_full_unstemmed	Orexinergic descending inhibitory pathway mediates linalool odor-induced analgesia in mice
title_sort	orexinergic descending inhibitory pathway mediates linalool odor-induced analgesia in mice
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/673b3c0670f2485484880dfedd516320
work_keys_str_mv	AT yurinahiga orexinergicdescendinginhibitorypathwaymediateslinaloolodorinducedanalgesiainmice AT hidekikashiwadani orexinergicdescendinginhibitorypathwaymediateslinaloolodorinducedanalgesiainmice AT mitsutakasugimura orexinergicdescendinginhibitorypathwaymediateslinaloolodorinducedanalgesiainmice AT tomoyukikuwaki orexinergicdescendinginhibitorypathwaymediateslinaloolodorinducedanalgesiainmice
_version_	1718382803568033792

Orexinergic descending inhibitory pathway mediates linalool odor-induced analgesia in mice

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