Lack of Association between Chlamydophila psittaci and Ocular Adnexal MALT Lymphoma in Korean Patients—Is the Geographic or Genetic Difference Significant?

Clamydophila psittaci (C. psittaci) has been proposed to be an etiologic factor in extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue (MALT lymphoma) in the ocular adnexa. However, the pathogenetical significance of the infection has not been...

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Autores principales:	Uiju Cho, Inju Cho, Sung Hak Lee, Suk Woo Yang, Seok Goo Cho, Youn Soo Lee, Hye Won Lee, Gyeongsin Park
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	<i>Chlamydophila</i> <i>psittaci</i> <i>Chlamydia</i> lymphoma B cell marginal zone MALT lymphoma Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/673ce986f41e4d04ab9a5e5ddf3fcde6
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id	oai:doaj.org-article:673ce986f41e4d04ab9a5e5ddf3fcde6
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spelling	oai:doaj.org-article:673ce986f41e4d04ab9a5e5ddf3fcde62021-11-25T17:21:20ZLack of Association between <i>Chlamydophila psittaci</i> and Ocular Adnexal MALT Lymphoma in Korean Patients—Is the Geographic or Genetic Difference Significant?10.3390/diagnostics111120692075-4418https://doaj.org/article/673ce986f41e4d04ab9a5e5ddf3fcde62021-11-01T00:00:00Zhttps://www.mdpi.com/2075-4418/11/11/2069https://doaj.org/toc/2075-4418<i>Clamydophila psittaci</i> (<i>C. psittaci</i>) has been proposed to be an etiologic factor in extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue (MALT lymphoma) in the ocular adnexa. However, the pathogenetical significance of the infection has not been fully elucidated. Many previous studies have shown controversial results regarding <i>C.</i> <i>psittaci</i> detection rates in said patients, ranging from 0 to 87%. We investigated the presence of <i>C. psittaci</i> in a single institutional cohort (<i>n</i> = 150) of ocular adnexal MALT lymphoma (OAML) patients in Korea. We tried to exclude the methodological biases derived from the different primer sets in polymerase chain reaction-based studies. For that reason, we applied five sets of primers, including four previously reported and one newly designed primer set. There was no case of <i>C. psittaci</i>-positive OAML in repeated trials validated with appropriate positive and negative controls. All 150 cases showed negative results with five primer sets. These results suggest that the pathogenetic role of <i>C. psittaci</i> in ocular adnexal MALT lymphoma might have been overestimated to date, at least in the Korean population. Therefore, the molecular diagnosis of <i>C. psittaci</i> is considered a very low priority.Uiju ChoInju ChoSung Hak LeeSuk Woo YangSeok Goo ChoYoun Soo LeeHye Won LeeGyeongsin ParkMDPI AGarticle<i>Chlamydophila</i> <i>psittaci</i><i>Chlamydia</i>lymphomaB cellmarginal zoneMALT lymphomaMedicine (General)R5-920ENDiagnostics, Vol 11, Iss 2069, p 2069 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	<i>Chlamydophila</i> <i>psittaci</i> <i>Chlamydia</i> lymphoma B cell marginal zone MALT lymphoma Medicine (General) R5-920
spellingShingle	<i>Chlamydophila</i> <i>psittaci</i> <i>Chlamydia</i> lymphoma B cell marginal zone MALT lymphoma Medicine (General) R5-920 Uiju Cho Inju Cho Sung Hak Lee Suk Woo Yang Seok Goo Cho Youn Soo Lee Hye Won Lee Gyeongsin Park Lack of Association between <i>Chlamydophila psittaci</i> and Ocular Adnexal MALT Lymphoma in Korean Patients—Is the Geographic or Genetic Difference Significant?
description	<i>Clamydophila psittaci</i> (<i>C. psittaci</i>) has been proposed to be an etiologic factor in extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue (MALT lymphoma) in the ocular adnexa. However, the pathogenetical significance of the infection has not been fully elucidated. Many previous studies have shown controversial results regarding <i>C.</i> <i>psittaci</i> detection rates in said patients, ranging from 0 to 87%. We investigated the presence of <i>C. psittaci</i> in a single institutional cohort (<i>n</i> = 150) of ocular adnexal MALT lymphoma (OAML) patients in Korea. We tried to exclude the methodological biases derived from the different primer sets in polymerase chain reaction-based studies. For that reason, we applied five sets of primers, including four previously reported and one newly designed primer set. There was no case of <i>C. psittaci</i>-positive OAML in repeated trials validated with appropriate positive and negative controls. All 150 cases showed negative results with five primer sets. These results suggest that the pathogenetic role of <i>C. psittaci</i> in ocular adnexal MALT lymphoma might have been overestimated to date, at least in the Korean population. Therefore, the molecular diagnosis of <i>C. psittaci</i> is considered a very low priority.
format	article
author	Uiju Cho Inju Cho Sung Hak Lee Suk Woo Yang Seok Goo Cho Youn Soo Lee Hye Won Lee Gyeongsin Park
author_facet	Uiju Cho Inju Cho Sung Hak Lee Suk Woo Yang Seok Goo Cho Youn Soo Lee Hye Won Lee Gyeongsin Park
author_sort	Uiju Cho
title	Lack of Association between <i>Chlamydophila psittaci</i> and Ocular Adnexal MALT Lymphoma in Korean Patients—Is the Geographic or Genetic Difference Significant?
title_short	Lack of Association between <i>Chlamydophila psittaci</i> and Ocular Adnexal MALT Lymphoma in Korean Patients—Is the Geographic or Genetic Difference Significant?
title_full	Lack of Association between <i>Chlamydophila psittaci</i> and Ocular Adnexal MALT Lymphoma in Korean Patients—Is the Geographic or Genetic Difference Significant?
title_fullStr	Lack of Association between <i>Chlamydophila psittaci</i> and Ocular Adnexal MALT Lymphoma in Korean Patients—Is the Geographic or Genetic Difference Significant?
title_full_unstemmed	Lack of Association between <i>Chlamydophila psittaci</i> and Ocular Adnexal MALT Lymphoma in Korean Patients—Is the Geographic or Genetic Difference Significant?
title_sort	lack of association between <i>chlamydophila psittaci</i> and ocular adnexal malt lymphoma in korean patients—is the geographic or genetic difference significant?
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/673ce986f41e4d04ab9a5e5ddf3fcde6
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Lack of Association between <i>Chlamydophila psittaci</i> and Ocular Adnexal MALT Lymphoma in Korean Patients—Is the Geographic or Genetic Difference Significant?

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