Proliferative polyploid cells give rise to tumors via ploidy reduction

Proliferative polyploid cells give rise to tumors via ploidy reduction

The involvement of polyploid hepatocytes in liver tumorigenesis is unclear. Here the authors use in vivo lineage tracing and show that polyploid hepatocytes initiate tumour formation through frequent ploidy reduction.

Guardado en:
Detalles Bibliográficos
Autores principales: Tomonori Matsumoto, Leslie Wakefield, Alexander Peters, Myron Peto, Paul Spellman, Markus Grompe
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
Materias:
Science
Q
Acceso en línea:https://doaj.org/article/6740ee9eb13f4308b1052f02c670e913
Etiquetas: Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
id oai:doaj.org-article:6740ee9eb13f4308b1052f02c670e913
record_format dspace
spelling oai:doaj.org-article:6740ee9eb13f4308b1052f02c670e9132021-12-02T13:57:32ZProliferative polyploid cells give rise to tumors via ploidy reduction10.1038/s41467-021-20916-y2041-1723https://doaj.org/article/6740ee9eb13f4308b1052f02c670e9132021-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-20916-yhttps://doaj.org/toc/2041-1723The involvement of polyploid hepatocytes in liver tumorigenesis is unclear. Here the authors use in vivo lineage tracing and show that polyploid hepatocytes initiate tumour formation through frequent ploidy reduction.Tomonori MatsumotoLeslie WakefieldAlexander PetersMyron PetoPaul SpellmanMarkus GrompeNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-11 (2021)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Tomonori Matsumoto
Leslie Wakefield
Alexander Peters
Myron Peto
Paul Spellman
Markus Grompe
Proliferative polyploid cells give rise to tumors via ploidy reduction
description The involvement of polyploid hepatocytes in liver tumorigenesis is unclear. Here the authors use in vivo lineage tracing and show that polyploid hepatocytes initiate tumour formation through frequent ploidy reduction.
format article
author Tomonori Matsumoto
Leslie Wakefield
Alexander Peters
Myron Peto
Paul Spellman
Markus Grompe
author_facet Tomonori Matsumoto
Leslie Wakefield
Alexander Peters
Myron Peto
Paul Spellman
Markus Grompe
author_sort Tomonori Matsumoto
title Proliferative polyploid cells give rise to tumors via ploidy reduction
title_short Proliferative polyploid cells give rise to tumors via ploidy reduction
title_full Proliferative polyploid cells give rise to tumors via ploidy reduction
title_fullStr Proliferative polyploid cells give rise to tumors via ploidy reduction
title_full_unstemmed Proliferative polyploid cells give rise to tumors via ploidy reduction
title_sort proliferative polyploid cells give rise to tumors via ploidy reduction
publisher Nature Portfolio
publishDate 2021
url https://doaj.org/article/6740ee9eb13f4308b1052f02c670e913
work_keys_str_mv AT tomonorimatsumoto proliferativepolyploidcellsgiverisetotumorsviaploidyreduction
AT lesliewakefield proliferativepolyploidcellsgiverisetotumorsviaploidyreduction
AT alexanderpeters proliferativepolyploidcellsgiverisetotumorsviaploidyreduction
AT myronpeto proliferativepolyploidcellsgiverisetotumorsviaploidyreduction
AT paulspellman proliferativepolyploidcellsgiverisetotumorsviaploidyreduction
AT markusgrompe proliferativepolyploidcellsgiverisetotumorsviaploidyreduction
_version_ 1718392325884870656

Ejemplares similares