Mutation bias and GC content shape antimutator invasions

Mutators are expected to re-evolve low mutation rates to reduce deleterious load, but empirical evidence is mixed. Here, the authors show that load can vary across mutators and genetic backgrounds, which their simulations suggest can substantially alter antimutator dynamics.

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Detalles Bibliográficos
Autores principales:	Alejandro Couce, Olivier Tenaillon
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/67417fa7d81b4f77964910427aefd29a
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spelling	oai:doaj.org-article:67417fa7d81b4f77964910427aefd29a2021-12-02T15:35:29ZMutation bias and GC content shape antimutator invasions10.1038/s41467-019-11217-62041-1723https://doaj.org/article/67417fa7d81b4f77964910427aefd29a2019-07-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-11217-6https://doaj.org/toc/2041-1723Mutators are expected to re-evolve low mutation rates to reduce deleterious load, but empirical evidence is mixed. Here, the authors show that load can vary across mutators and genetic backgrounds, which their simulations suggest can substantially alter antimutator dynamics.Alejandro CouceOlivier TenaillonNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-9 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Alejandro Couce Olivier Tenaillon Mutation bias and GC content shape antimutator invasions
description	Mutators are expected to re-evolve low mutation rates to reduce deleterious load, but empirical evidence is mixed. Here, the authors show that load can vary across mutators and genetic backgrounds, which their simulations suggest can substantially alter antimutator dynamics.
format	article
author	Alejandro Couce Olivier Tenaillon
author_facet	Alejandro Couce Olivier Tenaillon
author_sort	Alejandro Couce
title	Mutation bias and GC content shape antimutator invasions
title_short	Mutation bias and GC content shape antimutator invasions
title_full	Mutation bias and GC content shape antimutator invasions
title_fullStr	Mutation bias and GC content shape antimutator invasions
title_full_unstemmed	Mutation bias and GC content shape antimutator invasions
title_sort	mutation bias and gc content shape antimutator invasions
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/67417fa7d81b4f77964910427aefd29a
work_keys_str_mv	AT alejandrocouce mutationbiasandgccontentshapeantimutatorinvasions AT oliviertenaillon mutationbiasandgccontentshapeantimutatorinvasions
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Mutation bias and GC content shape antimutator invasions

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