Insight into Potential Anticancer Activity of Algal Flavonoids: Current Status and Challenges

Flavonoids are some of the most precious phytochemicals, believed to be found largely in terrestrial plants. With the advancement of phytochemical research and marine bioprospecting, flavonoids have also been reported by the research of microalgae and macroalgae. High growth rate with minimal nutrit...

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Autores principales:	Umme Tamanna Ferdous, Zetty Norhana Balia Yusof
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	anticancer antioxidant flavonoid microalgae seaweed Organic chemistry QD241-441
Acceso en línea:	https://doaj.org/article/67444843de8147bd9d1dcfa50cd2bee1
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spelling	oai:doaj.org-article:67444843de8147bd9d1dcfa50cd2bee12021-11-25T18:27:43ZInsight into Potential Anticancer Activity of Algal Flavonoids: Current Status and Challenges10.3390/molecules262268441420-3049https://doaj.org/article/67444843de8147bd9d1dcfa50cd2bee12021-11-01T00:00:00Zhttps://www.mdpi.com/1420-3049/26/22/6844https://doaj.org/toc/1420-3049Flavonoids are some of the most precious phytochemicals, believed to be found largely in terrestrial plants. With the advancement of phytochemical research and marine bioprospecting, flavonoids have also been reported by the research of microalgae and macroalgae. High growth rate with minimal nutritional and growth requirement, saving arable land and rich metabolic profile make microalgae an excellent repertoire of novel anticancer compounds, such as flavonoids. In addition, marine algae, especially seaweeds contain different types of flavonoids which are assumed to have unique chemical structures and bioactivities than their terrestrial counterparts. Flavonoids are not only good antioxidants but also have the abilities to kill cancer cells by inducing apoptosis and autophagy. However, the study of the anticancer properties of flavonoids is largely limited to terrestrial plants. This review offers an insight into the distribution of different classes of flavonoids in eukaryotic microalgae, cyanobacteria and seaweeds with their possible anticancer activities. In addition, extraction and purification methods of these flavonoids have been highlighted. Finally, prospects and challenges to use algal flavonoids as anticancer agents have been discussed.Umme Tamanna FerdousZetty Norhana Balia YusofMDPI AGarticleanticancerantioxidantflavonoidmicroalgaeseaweedOrganic chemistryQD241-441ENMolecules, Vol 26, Iss 6844, p 6844 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	anticancer antioxidant flavonoid microalgae seaweed Organic chemistry QD241-441
spellingShingle	anticancer antioxidant flavonoid microalgae seaweed Organic chemistry QD241-441 Umme Tamanna Ferdous Zetty Norhana Balia Yusof Insight into Potential Anticancer Activity of Algal Flavonoids: Current Status and Challenges
description	Flavonoids are some of the most precious phytochemicals, believed to be found largely in terrestrial plants. With the advancement of phytochemical research and marine bioprospecting, flavonoids have also been reported by the research of microalgae and macroalgae. High growth rate with minimal nutritional and growth requirement, saving arable land and rich metabolic profile make microalgae an excellent repertoire of novel anticancer compounds, such as flavonoids. In addition, marine algae, especially seaweeds contain different types of flavonoids which are assumed to have unique chemical structures and bioactivities than their terrestrial counterparts. Flavonoids are not only good antioxidants but also have the abilities to kill cancer cells by inducing apoptosis and autophagy. However, the study of the anticancer properties of flavonoids is largely limited to terrestrial plants. This review offers an insight into the distribution of different classes of flavonoids in eukaryotic microalgae, cyanobacteria and seaweeds with their possible anticancer activities. In addition, extraction and purification methods of these flavonoids have been highlighted. Finally, prospects and challenges to use algal flavonoids as anticancer agents have been discussed.
format	article
author	Umme Tamanna Ferdous Zetty Norhana Balia Yusof
author_facet	Umme Tamanna Ferdous Zetty Norhana Balia Yusof
author_sort	Umme Tamanna Ferdous
title	Insight into Potential Anticancer Activity of Algal Flavonoids: Current Status and Challenges
title_short	Insight into Potential Anticancer Activity of Algal Flavonoids: Current Status and Challenges
title_full	Insight into Potential Anticancer Activity of Algal Flavonoids: Current Status and Challenges
title_fullStr	Insight into Potential Anticancer Activity of Algal Flavonoids: Current Status and Challenges
title_full_unstemmed	Insight into Potential Anticancer Activity of Algal Flavonoids: Current Status and Challenges
title_sort	insight into potential anticancer activity of algal flavonoids: current status and challenges
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/67444843de8147bd9d1dcfa50cd2bee1
work_keys_str_mv	AT ummetamannaferdous insightintopotentialanticanceractivityofalgalflavonoidscurrentstatusandchallenges AT zettynorhanabaliayusof insightintopotentialanticanceractivityofalgalflavonoidscurrentstatusandchallenges
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Insight into Potential Anticancer Activity of Algal Flavonoids: Current Status and Challenges

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