Regulation of T cell afferent lymphatic migration by targeting LTβR-mediated non-classical NFκB signaling

Lymphotoxin beta receptor (LTβR) signalling regulates leukocyte migration through the lymphatic endothelial layers. Here, the authors show that treatment of an LTβR-derived decoy peptide can target the non-classical NFκB pathway to inhibit T cell and dendritic cell migration and ameliorate contact h...

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Autores principales:	Wenji Piao, Yanbao Xiong, Konrad Famulski, C. Colin Brinkman, Lushen Li, Nicholas Toney, Chelsea Wagner, Vikas Saxena, Thomas Simon, Jonathan S. Bromberg
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/674590e81a5d4d56a95ca57bb0bc7d07
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spelling	oai:doaj.org-article:674590e81a5d4d56a95ca57bb0bc7d072021-12-02T17:31:42ZRegulation of T cell afferent lymphatic migration by targeting LTβR-mediated non-classical NFκB signaling10.1038/s41467-018-05412-02041-1723https://doaj.org/article/674590e81a5d4d56a95ca57bb0bc7d072018-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-05412-0https://doaj.org/toc/2041-1723Lymphotoxin beta receptor (LTβR) signalling regulates leukocyte migration through the lymphatic endothelial layers. Here, the authors show that treatment of an LTβR-derived decoy peptide can target the non-classical NFκB pathway to inhibit T cell and dendritic cell migration and ameliorate contact hypersensitivity in mouse models.Wenji PiaoYanbao XiongKonrad FamulskiC. Colin BrinkmanLushen LiNicholas ToneyChelsea WagnerVikas SaxenaThomas SimonJonathan S. BrombergNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-15 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Wenji Piao Yanbao Xiong Konrad Famulski C. Colin Brinkman Lushen Li Nicholas Toney Chelsea Wagner Vikas Saxena Thomas Simon Jonathan S. Bromberg Regulation of T cell afferent lymphatic migration by targeting LTβR-mediated non-classical NFκB signaling
description	Lymphotoxin beta receptor (LTβR) signalling regulates leukocyte migration through the lymphatic endothelial layers. Here, the authors show that treatment of an LTβR-derived decoy peptide can target the non-classical NFκB pathway to inhibit T cell and dendritic cell migration and ameliorate contact hypersensitivity in mouse models.
format	article
author	Wenji Piao Yanbao Xiong Konrad Famulski C. Colin Brinkman Lushen Li Nicholas Toney Chelsea Wagner Vikas Saxena Thomas Simon Jonathan S. Bromberg
author_facet	Wenji Piao Yanbao Xiong Konrad Famulski C. Colin Brinkman Lushen Li Nicholas Toney Chelsea Wagner Vikas Saxena Thomas Simon Jonathan S. Bromberg
author_sort	Wenji Piao
title	Regulation of T cell afferent lymphatic migration by targeting LTβR-mediated non-classical NFκB signaling
title_short	Regulation of T cell afferent lymphatic migration by targeting LTβR-mediated non-classical NFκB signaling
title_full	Regulation of T cell afferent lymphatic migration by targeting LTβR-mediated non-classical NFκB signaling
title_fullStr	Regulation of T cell afferent lymphatic migration by targeting LTβR-mediated non-classical NFκB signaling
title_full_unstemmed	Regulation of T cell afferent lymphatic migration by targeting LTβR-mediated non-classical NFκB signaling
title_sort	regulation of t cell afferent lymphatic migration by targeting ltβr-mediated non-classical nfκb signaling
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/674590e81a5d4d56a95ca57bb0bc7d07
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Regulation of T cell afferent lymphatic migration by targeting LTβR-mediated non-classical NFκB signaling

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