Avoidance memory requires CaMKII activity to persist after recall

Abstract Avoidance memory is destabilized when recalled concurrently with conflicting information, and must undergo a hippocampus-dependent restabilization process called reconsolidation to persist. CaMKII is a serine/threonine protein kinase essential for memory processing; however, its possible in...

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Autores principales:	Andressa Radiske, Maria Carolina Gonzalez, Janine I. Rossato, Gênedy Apolinário, João R. de Oliveira, Lia R. M. Bevilaqua, Martín Cammarota
Formato:	article
Lenguaje:	EN
Publicado:	BMC 2021
Materias:	Reconsolidation PTSD Fear Hippocampus Retrieval Neurology. Diseases of the nervous system RC346-429
Acceso en línea:	https://doaj.org/article/674679b96aa943ea8b8f97e59bc6c340
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id	oai:doaj.org-article:674679b96aa943ea8b8f97e59bc6c340
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spelling	oai:doaj.org-article:674679b96aa943ea8b8f97e59bc6c3402021-11-21T12:41:54ZAvoidance memory requires CaMKII activity to persist after recall10.1186/s13041-021-00877-51756-6606https://doaj.org/article/674679b96aa943ea8b8f97e59bc6c3402021-11-01T00:00:00Zhttps://doi.org/10.1186/s13041-021-00877-5https://doaj.org/toc/1756-6606Abstract Avoidance memory is destabilized when recalled concurrently with conflicting information, and must undergo a hippocampus-dependent restabilization process called reconsolidation to persist. CaMKII is a serine/threonine protein kinase essential for memory processing; however, its possible involvement in avoidance memory reconsolidation has not yet been studied. Using pharmacological, electrophysiological and optogenetic tools, we found that in adult male Wistar rats hippocampal CaMKII is necessary to reconsolidate avoidance memory, but not to keep it stored while inactive, and that blocking reconsolidation via CaMKII inhibition erases learned avoidance responses.Andressa RadiskeMaria Carolina GonzalezJanine I. RossatoGênedy ApolinárioJoão R. de OliveiraLia R. M. BevilaquaMartín CammarotaBMCarticleReconsolidationPTSDFearHippocampusRetrievalNeurology. Diseases of the nervous systemRC346-429ENMolecular Brain, Vol 14, Iss 1, Pp 1-4 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Reconsolidation PTSD Fear Hippocampus Retrieval Neurology. Diseases of the nervous system RC346-429
spellingShingle	Reconsolidation PTSD Fear Hippocampus Retrieval Neurology. Diseases of the nervous system RC346-429 Andressa Radiske Maria Carolina Gonzalez Janine I. Rossato Gênedy Apolinário João R. de Oliveira Lia R. M. Bevilaqua Martín Cammarota Avoidance memory requires CaMKII activity to persist after recall
description	Abstract Avoidance memory is destabilized when recalled concurrently with conflicting information, and must undergo a hippocampus-dependent restabilization process called reconsolidation to persist. CaMKII is a serine/threonine protein kinase essential for memory processing; however, its possible involvement in avoidance memory reconsolidation has not yet been studied. Using pharmacological, electrophysiological and optogenetic tools, we found that in adult male Wistar rats hippocampal CaMKII is necessary to reconsolidate avoidance memory, but not to keep it stored while inactive, and that blocking reconsolidation via CaMKII inhibition erases learned avoidance responses.
format	article
author	Andressa Radiske Maria Carolina Gonzalez Janine I. Rossato Gênedy Apolinário João R. de Oliveira Lia R. M. Bevilaqua Martín Cammarota
author_facet	Andressa Radiske Maria Carolina Gonzalez Janine I. Rossato Gênedy Apolinário João R. de Oliveira Lia R. M. Bevilaqua Martín Cammarota
author_sort	Andressa Radiske
title	Avoidance memory requires CaMKII activity to persist after recall
title_short	Avoidance memory requires CaMKII activity to persist after recall
title_full	Avoidance memory requires CaMKII activity to persist after recall
title_fullStr	Avoidance memory requires CaMKII activity to persist after recall
title_full_unstemmed	Avoidance memory requires CaMKII activity to persist after recall
title_sort	avoidance memory requires camkii activity to persist after recall
publisher	BMC
publishDate	2021
url	https://doaj.org/article/674679b96aa943ea8b8f97e59bc6c340
work_keys_str_mv	AT andressaradiske avoidancememoryrequirescamkiiactivitytopersistafterrecall AT mariacarolinagonzalez avoidancememoryrequirescamkiiactivitytopersistafterrecall AT janineirossato avoidancememoryrequirescamkiiactivitytopersistafterrecall AT genedyapolinario avoidancememoryrequirescamkiiactivitytopersistafterrecall AT joaordeoliveira avoidancememoryrequirescamkiiactivitytopersistafterrecall AT liarmbevilaqua avoidancememoryrequirescamkiiactivitytopersistafterrecall AT martincammarota avoidancememoryrequirescamkiiactivitytopersistafterrecall
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Avoidance memory requires CaMKII activity to persist after recall

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