Genome-wide profiling in colorectal cancer identifies PHF19 and TBC1D16 as oncogenic super enhancers

Active enhancers are still understudied in colorectal cancers (CRC). Here the authors analyse active enhancers in CRC patients using genomics, transcriptomics, and epigenomics, identifying and validating variant super-enhancer loci as well as KLF3 as a relevant transcription factor.

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Autores principales:	Qing-Lan Li, Xiang Lin, Ya-Li Yu, Lin Chen, Qi-Xin Hu, Meng Chen, Nan Cao, Chen Zhao, Chen-Yu Wang, Cheng-Wei Huang, Lian-Yun Li, Mei Ye, Min Wu
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/674cf176220842dd92978ff6bc45defa
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spelling	oai:doaj.org-article:674cf176220842dd92978ff6bc45defa2021-11-08T11:12:21ZGenome-wide profiling in colorectal cancer identifies PHF19 and TBC1D16 as oncogenic super enhancers10.1038/s41467-021-26600-52041-1723https://doaj.org/article/674cf176220842dd92978ff6bc45defa2021-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-26600-5https://doaj.org/toc/2041-1723Active enhancers are still understudied in colorectal cancers (CRC). Here the authors analyse active enhancers in CRC patients using genomics, transcriptomics, and epigenomics, identifying and validating variant super-enhancer loci as well as KLF3 as a relevant transcription factor.Qing-Lan LiXiang LinYa-Li YuLin ChenQi-Xin HuMeng ChenNan CaoChen ZhaoChen-Yu WangCheng-Wei HuangLian-Yun LiMei YeMin WuNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Qing-Lan Li Xiang Lin Ya-Li Yu Lin Chen Qi-Xin Hu Meng Chen Nan Cao Chen Zhao Chen-Yu Wang Cheng-Wei Huang Lian-Yun Li Mei Ye Min Wu Genome-wide profiling in colorectal cancer identifies PHF19 and TBC1D16 as oncogenic super enhancers
description	Active enhancers are still understudied in colorectal cancers (CRC). Here the authors analyse active enhancers in CRC patients using genomics, transcriptomics, and epigenomics, identifying and validating variant super-enhancer loci as well as KLF3 as a relevant transcription factor.
format	article
author	Qing-Lan Li Xiang Lin Ya-Li Yu Lin Chen Qi-Xin Hu Meng Chen Nan Cao Chen Zhao Chen-Yu Wang Cheng-Wei Huang Lian-Yun Li Mei Ye Min Wu
author_facet	Qing-Lan Li Xiang Lin Ya-Li Yu Lin Chen Qi-Xin Hu Meng Chen Nan Cao Chen Zhao Chen-Yu Wang Cheng-Wei Huang Lian-Yun Li Mei Ye Min Wu
author_sort	Qing-Lan Li
title	Genome-wide profiling in colorectal cancer identifies PHF19 and TBC1D16 as oncogenic super enhancers
title_short	Genome-wide profiling in colorectal cancer identifies PHF19 and TBC1D16 as oncogenic super enhancers
title_full	Genome-wide profiling in colorectal cancer identifies PHF19 and TBC1D16 as oncogenic super enhancers
title_fullStr	Genome-wide profiling in colorectal cancer identifies PHF19 and TBC1D16 as oncogenic super enhancers
title_full_unstemmed	Genome-wide profiling in colorectal cancer identifies PHF19 and TBC1D16 as oncogenic super enhancers
title_sort	genome-wide profiling in colorectal cancer identifies phf19 and tbc1d16 as oncogenic super enhancers
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/674cf176220842dd92978ff6bc45defa
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Genome-wide profiling in colorectal cancer identifies PHF19 and TBC1D16 as oncogenic super enhancers

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