Pyroptosis: A New Regulating Mechanism in Cardiovascular Disease
Nan Ji,1,2,* Zhongwen Qi,1,* Yueyao Wang,1 Xiaoya Yang,1 Zhipeng Yan,1 Meng Li,1 Qihui Ge,1 Junping Zhang1 1First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin, 300183, People’s Republic of China; 2National Clinical Research Center for Chinese Medicine Ac...
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Dove Medical Press
2021
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oai:doaj.org-article:674f6b8743ae427b859a77a8a5c3ce3d2021-12-02T17:44:39ZPyroptosis: A New Regulating Mechanism in Cardiovascular Disease1178-7031https://doaj.org/article/674f6b8743ae427b859a77a8a5c3ce3d2021-06-01T00:00:00Zhttps://www.dovepress.com/pyroptosis-a-new-regulating-mechanism-in-cardiovascular-disease-peer-reviewed-fulltext-article-JIRhttps://doaj.org/toc/1178-7031Nan Ji,1,2,* Zhongwen Qi,1,* Yueyao Wang,1 Xiaoya Yang,1 Zhipeng Yan,1 Meng Li,1 Qihui Ge,1 Junping Zhang1 1First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin, 300183, People’s Republic of China; 2National Clinical Research Center for Chinese Medicine Acupuncture and Moxibustion, Tianjin, 300193, People’s Republic of China*These authors contributed equally to this workCorrespondence: Junping Zhang Email tjzhtcm@163.comAbstract: Pyroptosis is a kind of pro-inflammatory cell death. Compared with autophagy and apoptosis, pyroptosis has unique characteristics in morphology and mechanism. Specifically, pyroptosis is a kind of cell lysis mediated by the Gasdermin family, releases inflammatory cytokines IL-1β and IL-18. There are three different forms of mechanism, which are caspase-1-mediated, caspase-4/5/11-mediated and caspase-3-mediated. A large number of studies have proved that pyroptosis is closely related to cardiovascular disease. This paper reviewed the recent progress in the related research on pyroptosis and myocardial infarction, ischemia-reperfusion, atherosclerosis, diabetic cardiomyopathy, arrhythmia, heart failure hypertension and Kawasaki disease. Therefore, we believe that pyroptosis may be a new therapeutic target in the cardiovascular field.Keywords: pyroptosis, cardiopathy, NLRP3, caspase-1, IL-1βJi NQi ZWang YYang XYan ZLi MGe QZhang JDove Medical Pressarticlepyroptosiscardiopathynlrp3caspase-1il-1βPathologyRB1-214Therapeutics. PharmacologyRM1-950ENJournal of Inflammation Research, Vol Volume 14, Pp 2647-2666 (2021) |
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pyroptosis cardiopathy nlrp3 caspase-1 il-1β Pathology RB1-214 Therapeutics. Pharmacology RM1-950 |
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pyroptosis cardiopathy nlrp3 caspase-1 il-1β Pathology RB1-214 Therapeutics. Pharmacology RM1-950 Ji N Qi Z Wang Y Yang X Yan Z Li M Ge Q Zhang J Pyroptosis: A New Regulating Mechanism in Cardiovascular Disease |
| description |
Nan Ji,1,2,* Zhongwen Qi,1,* Yueyao Wang,1 Xiaoya Yang,1 Zhipeng Yan,1 Meng Li,1 Qihui Ge,1 Junping Zhang1 1First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin, 300183, People’s Republic of China; 2National Clinical Research Center for Chinese Medicine Acupuncture and Moxibustion, Tianjin, 300193, People’s Republic of China*These authors contributed equally to this workCorrespondence: Junping Zhang Email tjzhtcm@163.comAbstract: Pyroptosis is a kind of pro-inflammatory cell death. Compared with autophagy and apoptosis, pyroptosis has unique characteristics in morphology and mechanism. Specifically, pyroptosis is a kind of cell lysis mediated by the Gasdermin family, releases inflammatory cytokines IL-1β and IL-18. There are three different forms of mechanism, which are caspase-1-mediated, caspase-4/5/11-mediated and caspase-3-mediated. A large number of studies have proved that pyroptosis is closely related to cardiovascular disease. This paper reviewed the recent progress in the related research on pyroptosis and myocardial infarction, ischemia-reperfusion, atherosclerosis, diabetic cardiomyopathy, arrhythmia, heart failure hypertension and Kawasaki disease. Therefore, we believe that pyroptosis may be a new therapeutic target in the cardiovascular field.Keywords: pyroptosis, cardiopathy, NLRP3, caspase-1, IL-1β |
| format |
article |
| author |
Ji N Qi Z Wang Y Yang X Yan Z Li M Ge Q Zhang J |
| author_facet |
Ji N Qi Z Wang Y Yang X Yan Z Li M Ge Q Zhang J |
| author_sort |
Ji N |
| title |
Pyroptosis: A New Regulating Mechanism in Cardiovascular Disease |
| title_short |
Pyroptosis: A New Regulating Mechanism in Cardiovascular Disease |
| title_full |
Pyroptosis: A New Regulating Mechanism in Cardiovascular Disease |
| title_fullStr |
Pyroptosis: A New Regulating Mechanism in Cardiovascular Disease |
| title_full_unstemmed |
Pyroptosis: A New Regulating Mechanism in Cardiovascular Disease |
| title_sort |
pyroptosis: a new regulating mechanism in cardiovascular disease |
| publisher |
Dove Medical Press |
| publishDate |
2021 |
| url |
https://doaj.org/article/674f6b8743ae427b859a77a8a5c3ce3d |
| work_keys_str_mv |
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| _version_ |
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