AUTOIMMUNE ORIGIN OF SARCOIDOSIS: DETERMINATION OF SPECIFIC IMMUNE COMPLEXES IN PATIENTS WITH RESPIRATORY SARCOIDOSIS

The etiology of sarcoidosis is not completely understood. A hypothesis exists about the relationship between sarcoidosis and a complex of pathological autoimmune reactions that occur under the influence of triggering factors. In this study, specific immune complexes in the blood plasma of patients h...

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Autores principales:	Yu. S. Zinchenko, A. A. Starshinova, M. V. Filatov, N. V. Denisova, S. B. Landa, V. S. Burdakov, P. K. Yablonskiy
Formato:	article
Lenguaje:	RU
Publicado:	SPb RAACI 2019
Materias:	sarcoidosis autoimmunity specific immune complexes dynamic light scattering method Immunologic diseases. Allergy RC581-607
Acceso en línea:	https://doaj.org/article/6753db96dc274647b7122aaee64e2bee
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spelling	oai:doaj.org-article:6753db96dc274647b7122aaee64e2bee2021-11-18T08:03:48ZAUTOIMMUNE ORIGIN OF SARCOIDOSIS: DETERMINATION OF SPECIFIC IMMUNE COMPLEXES IN PATIENTS WITH RESPIRATORY SARCOIDOSIS1563-06252313-741X10.15789/1563-0625-2019-3-479-486https://doaj.org/article/6753db96dc274647b7122aaee64e2bee2019-07-01T00:00:00Zhttps://www.mimmun.ru/mimmun/article/view/1821https://doaj.org/toc/1563-0625https://doaj.org/toc/2313-741XThe etiology of sarcoidosis is not completely understood. A hypothesis exists about the relationship between sarcoidosis and a complex of pathological autoimmune reactions that occur under the influence of triggering factors. In this study, specific immune complexes in the blood plasma of patients have been determined, which can indirectly reveal the causes of the disease.The study included 33 patients with lung sarcoidosis (I group), compared to 24 healthy donors who served as a control group (II group). The patients underwent standard examination. Their blood plasma was investigated by the dynamic light scattering method with addition of tuberculosis antigens (ESAT-6/SFP-10) and “lung healthy tissue extract”. Statistical analysis was performed using the Statistica 7.0 program. Test results were considered significant at p < 0.05.Аccording to the data obtained, addition of ESAT-6/SFP-10 to patient’s blood plasma almost did not lead to the formation of immune complexes in most samples. Meanwhile, development of such complexes after addition of “lung tissue extract” was revealed in all the patients. The immune complexes were not detected in any donor from control group after stimulation with both kinds of antigens (p < 0.01).The data on distinct formation of immune complexes with the addition of “lung healthy tissue extract” in patients with lung sarcoidosis may be considered an indirect evidence for occurrence of autoimmune reaction under the influence of some pathogenic factors. Absence of de novo immune complex formation after addition of tuberculosis antigens (ESAT-6/SFP-10) makes it unlikely any direct effects of tuberculosis bacteria upon development of sarcoidosis.Yu. S. ZinchenkoA. A. StarshinovaM. V. FilatovN. V. DenisovaS. B. LandaV. S. BurdakovP. K. YablonskiySPb RAACIarticlesarcoidosisautoimmunityspecific immune complexesdynamic light scattering methodImmunologic diseases. AllergyRC581-607RUMedicinskaâ Immunologiâ, Vol 21, Iss 3, Pp 479-486 (2019)
institution	DOAJ
collection	DOAJ
language	RU
topic	sarcoidosis autoimmunity specific immune complexes dynamic light scattering method Immunologic diseases. Allergy RC581-607
spellingShingle	sarcoidosis autoimmunity specific immune complexes dynamic light scattering method Immunologic diseases. Allergy RC581-607 Yu. S. Zinchenko A. A. Starshinova M. V. Filatov N. V. Denisova S. B. Landa V. S. Burdakov P. K. Yablonskiy AUTOIMMUNE ORIGIN OF SARCOIDOSIS: DETERMINATION OF SPECIFIC IMMUNE COMPLEXES IN PATIENTS WITH RESPIRATORY SARCOIDOSIS
description	The etiology of sarcoidosis is not completely understood. A hypothesis exists about the relationship between sarcoidosis and a complex of pathological autoimmune reactions that occur under the influence of triggering factors. In this study, specific immune complexes in the blood plasma of patients have been determined, which can indirectly reveal the causes of the disease.The study included 33 patients with lung sarcoidosis (I group), compared to 24 healthy donors who served as a control group (II group). The patients underwent standard examination. Their blood plasma was investigated by the dynamic light scattering method with addition of tuberculosis antigens (ESAT-6/SFP-10) and “lung healthy tissue extract”. Statistical analysis was performed using the Statistica 7.0 program. Test results were considered significant at p < 0.05.Аccording to the data obtained, addition of ESAT-6/SFP-10 to patient’s blood plasma almost did not lead to the formation of immune complexes in most samples. Meanwhile, development of such complexes after addition of “lung tissue extract” was revealed in all the patients. The immune complexes were not detected in any donor from control group after stimulation with both kinds of antigens (p < 0.01).The data on distinct formation of immune complexes with the addition of “lung healthy tissue extract” in patients with lung sarcoidosis may be considered an indirect evidence for occurrence of autoimmune reaction under the influence of some pathogenic factors. Absence of de novo immune complex formation after addition of tuberculosis antigens (ESAT-6/SFP-10) makes it unlikely any direct effects of tuberculosis bacteria upon development of sarcoidosis.
format	article
author	Yu. S. Zinchenko A. A. Starshinova M. V. Filatov N. V. Denisova S. B. Landa V. S. Burdakov P. K. Yablonskiy
author_facet	Yu. S. Zinchenko A. A. Starshinova M. V. Filatov N. V. Denisova S. B. Landa V. S. Burdakov P. K. Yablonskiy
author_sort	Yu. S. Zinchenko
title	AUTOIMMUNE ORIGIN OF SARCOIDOSIS: DETERMINATION OF SPECIFIC IMMUNE COMPLEXES IN PATIENTS WITH RESPIRATORY SARCOIDOSIS
title_short	AUTOIMMUNE ORIGIN OF SARCOIDOSIS: DETERMINATION OF SPECIFIC IMMUNE COMPLEXES IN PATIENTS WITH RESPIRATORY SARCOIDOSIS
title_full	AUTOIMMUNE ORIGIN OF SARCOIDOSIS: DETERMINATION OF SPECIFIC IMMUNE COMPLEXES IN PATIENTS WITH RESPIRATORY SARCOIDOSIS
title_fullStr	AUTOIMMUNE ORIGIN OF SARCOIDOSIS: DETERMINATION OF SPECIFIC IMMUNE COMPLEXES IN PATIENTS WITH RESPIRATORY SARCOIDOSIS
title_full_unstemmed	AUTOIMMUNE ORIGIN OF SARCOIDOSIS: DETERMINATION OF SPECIFIC IMMUNE COMPLEXES IN PATIENTS WITH RESPIRATORY SARCOIDOSIS
title_sort	autoimmune origin of sarcoidosis: determination of specific immune complexes in patients with respiratory sarcoidosis
publisher	SPb RAACI
publishDate	2019
url	https://doaj.org/article/6753db96dc274647b7122aaee64e2bee
work_keys_str_mv	AT yuszinchenko autoimmuneoriginofsarcoidosisdeterminationofspecificimmunecomplexesinpatientswithrespiratorysarcoidosis AT aastarshinova autoimmuneoriginofsarcoidosisdeterminationofspecificimmunecomplexesinpatientswithrespiratorysarcoidosis AT mvfilatov autoimmuneoriginofsarcoidosisdeterminationofspecificimmunecomplexesinpatientswithrespiratorysarcoidosis AT nvdenisova autoimmuneoriginofsarcoidosisdeterminationofspecificimmunecomplexesinpatientswithrespiratorysarcoidosis AT sblanda autoimmuneoriginofsarcoidosisdeterminationofspecificimmunecomplexesinpatientswithrespiratorysarcoidosis AT vsburdakov autoimmuneoriginofsarcoidosisdeterminationofspecificimmunecomplexesinpatientswithrespiratorysarcoidosis AT pkyablonskiy autoimmuneoriginofsarcoidosisdeterminationofspecificimmunecomplexesinpatientswithrespiratorysarcoidosis
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AUTOIMMUNE ORIGIN OF SARCOIDOSIS: DETERMINATION OF SPECIFIC IMMUNE COMPLEXES IN PATIENTS WITH RESPIRATORY SARCOIDOSIS

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