A general framework for automatic closed-loop control of bladder voiding induced by intraspinal microstimulation in rats

Abstract Individuals with spinal cord injury or neurological disorders have problems in voiding function due to the dyssynergic contraction of the urethral sphincter. Here, we introduce a closed-loop control of intraspinal microstimulation (ISMS) for efficient bladder voiding. The strategy is based...

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Autores principales:	Abolhasan Yousefpour, Abbas Erfanian
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/675494800f1247a4a41b481787d928fe
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spelling	oai:doaj.org-article:675494800f1247a4a41b481787d928fe2021-12-02T13:30:34ZA general framework for automatic closed-loop control of bladder voiding induced by intraspinal microstimulation in rats10.1038/s41598-021-82933-72045-2322https://doaj.org/article/675494800f1247a4a41b481787d928fe2021-02-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-82933-7https://doaj.org/toc/2045-2322Abstract Individuals with spinal cord injury or neurological disorders have problems in voiding function due to the dyssynergic contraction of the urethral sphincter. Here, we introduce a closed-loop control of intraspinal microstimulation (ISMS) for efficient bladder voiding. The strategy is based on asynchronous two-electrode ISMS with combined pulse-amplitude and pulse-frequency modulation without requiring rhizotomy, neurotomy, or high-frequency blocking. Intermittent stimulation is alternately applied to the two electrodes that are implanted in the S2 lateral ventral horn and S1 dorsal gray commissure, to excite the bladder motoneurons and to inhibit the urethral sphincter motoneurons. Asynchronous stimulation would lead to reduce the net electric field and to maximize the selective stimulation. The proposed closed-loop system attains a highly voiding efficiency of 77.2–100%, with an average of 91.28 ± 8.4%. This work represents a promising approach to the development of a natural and robust motor neuroprosthesis device for restoring bladder functions.Abolhasan YousefpourAbbas ErfanianNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-16 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Abolhasan Yousefpour Abbas Erfanian A general framework for automatic closed-loop control of bladder voiding induced by intraspinal microstimulation in rats
description	Abstract Individuals with spinal cord injury or neurological disorders have problems in voiding function due to the dyssynergic contraction of the urethral sphincter. Here, we introduce a closed-loop control of intraspinal microstimulation (ISMS) for efficient bladder voiding. The strategy is based on asynchronous two-electrode ISMS with combined pulse-amplitude and pulse-frequency modulation without requiring rhizotomy, neurotomy, or high-frequency blocking. Intermittent stimulation is alternately applied to the two electrodes that are implanted in the S2 lateral ventral horn and S1 dorsal gray commissure, to excite the bladder motoneurons and to inhibit the urethral sphincter motoneurons. Asynchronous stimulation would lead to reduce the net electric field and to maximize the selective stimulation. The proposed closed-loop system attains a highly voiding efficiency of 77.2–100%, with an average of 91.28 ± 8.4%. This work represents a promising approach to the development of a natural and robust motor neuroprosthesis device for restoring bladder functions.
format	article
author	Abolhasan Yousefpour Abbas Erfanian
author_facet	Abolhasan Yousefpour Abbas Erfanian
author_sort	Abolhasan Yousefpour
title	A general framework for automatic closed-loop control of bladder voiding induced by intraspinal microstimulation in rats
title_short	A general framework for automatic closed-loop control of bladder voiding induced by intraspinal microstimulation in rats
title_full	A general framework for automatic closed-loop control of bladder voiding induced by intraspinal microstimulation in rats
title_fullStr	A general framework for automatic closed-loop control of bladder voiding induced by intraspinal microstimulation in rats
title_full_unstemmed	A general framework for automatic closed-loop control of bladder voiding induced by intraspinal microstimulation in rats
title_sort	general framework for automatic closed-loop control of bladder voiding induced by intraspinal microstimulation in rats
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/675494800f1247a4a41b481787d928fe
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A general framework for automatic closed-loop control of bladder voiding induced by intraspinal microstimulation in rats

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