The enzymatic activity of inositol hexakisphosphate kinase controls circulating phosphate in mammals

Inositol hexakisphosphate kinase (IP6K) is involved in diverse cellular signalling pathways, but the physiological roles of IP6K in vivo remain unknown in mammals. Here, the authors show that the enzymatic activity of IP6K is essential for phosphate regulation in vivo.

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Autores principales:	Yusuke Moritoh, Shin-ichi Abe, Hiroki Akiyama, Akihiro Kobayashi, Ryokichi Koyama, Ryoma Hara, Shizuo Kasai, Masanori Watanabe
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/6758204230a747738df3dd582c9c832d
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spelling	oai:doaj.org-article:6758204230a747738df3dd582c9c832d2021-12-02T16:27:51ZThe enzymatic activity of inositol hexakisphosphate kinase controls circulating phosphate in mammals10.1038/s41467-021-24934-82041-1723https://doaj.org/article/6758204230a747738df3dd582c9c832d2021-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-24934-8https://doaj.org/toc/2041-1723Inositol hexakisphosphate kinase (IP6K) is involved in diverse cellular signalling pathways, but the physiological roles of IP6K in vivo remain unknown in mammals. Here, the authors show that the enzymatic activity of IP6K is essential for phosphate regulation in vivo.Yusuke MoritohShin-ichi AbeHiroki AkiyamaAkihiro KobayashiRyokichi KoyamaRyoma HaraShizuo KasaiMasanori WatanabeNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Yusuke Moritoh Shin-ichi Abe Hiroki Akiyama Akihiro Kobayashi Ryokichi Koyama Ryoma Hara Shizuo Kasai Masanori Watanabe The enzymatic activity of inositol hexakisphosphate kinase controls circulating phosphate in mammals
description	Inositol hexakisphosphate kinase (IP6K) is involved in diverse cellular signalling pathways, but the physiological roles of IP6K in vivo remain unknown in mammals. Here, the authors show that the enzymatic activity of IP6K is essential for phosphate regulation in vivo.
format	article
author	Yusuke Moritoh Shin-ichi Abe Hiroki Akiyama Akihiro Kobayashi Ryokichi Koyama Ryoma Hara Shizuo Kasai Masanori Watanabe
author_facet	Yusuke Moritoh Shin-ichi Abe Hiroki Akiyama Akihiro Kobayashi Ryokichi Koyama Ryoma Hara Shizuo Kasai Masanori Watanabe
author_sort	Yusuke Moritoh
title	The enzymatic activity of inositol hexakisphosphate kinase controls circulating phosphate in mammals
title_short	The enzymatic activity of inositol hexakisphosphate kinase controls circulating phosphate in mammals
title_full	The enzymatic activity of inositol hexakisphosphate kinase controls circulating phosphate in mammals
title_fullStr	The enzymatic activity of inositol hexakisphosphate kinase controls circulating phosphate in mammals
title_full_unstemmed	The enzymatic activity of inositol hexakisphosphate kinase controls circulating phosphate in mammals
title_sort	enzymatic activity of inositol hexakisphosphate kinase controls circulating phosphate in mammals
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/6758204230a747738df3dd582c9c832d
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The enzymatic activity of inositol hexakisphosphate kinase controls circulating phosphate in mammals

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