Genome wide association study of body weight and feed efficiency traits in a commercial broiler chicken population, a re-visitation

Abstract Genome wide association study was conducted using a mixed linear model (MLM) approach that accounted for family structure to identify single nucleotide polymorphisms (SNPs) and candidate genes associated with body weight (BW) and feed efficiency (FE) traits in a broiler chicken population....

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Autores principales:	Wossenie Mebratie, Henry Reyer, Klaus Wimmers, Henk Bovenhuis, Just Jensen
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/6758b430489c49328634f4f2339194d6
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spelling	oai:doaj.org-article:6758b430489c49328634f4f2339194d62021-12-02T15:09:46ZGenome wide association study of body weight and feed efficiency traits in a commercial broiler chicken population, a re-visitation10.1038/s41598-018-37216-z2045-2322https://doaj.org/article/6758b430489c49328634f4f2339194d62019-01-01T00:00:00Zhttps://doi.org/10.1038/s41598-018-37216-zhttps://doaj.org/toc/2045-2322Abstract Genome wide association study was conducted using a mixed linear model (MLM) approach that accounted for family structure to identify single nucleotide polymorphisms (SNPs) and candidate genes associated with body weight (BW) and feed efficiency (FE) traits in a broiler chicken population. The results of the MLM approach were compared with the results of a general linear model approach that does not take family structure in to account. In total, 11 quantitative trait loci (QTL) and 21 SNPs, were identified to be significantly associated with BW traits and 5 QTL and 5 SNPs were found associated with FE traits using MLM approach. Besides some overlaps between the results of the two GWAS approaches, there are considerable differences in the detected QTL. Even though the genomic inflation factor (λ) values indicate that there is no strong family structure in this population, using models that account for the existing family structure may reduce bias and increase accuracy of the estimated SNP effects in the association analysis. The SNPs and candidate genes identified in this study provide information on the genetic background of BW and FE traits in broiler chickens and might be used as prior information for genomic selection.Wossenie MebratieHenry ReyerKlaus WimmersHenk BovenhuisJust JensenNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 9, Iss 1, Pp 1-10 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Wossenie Mebratie Henry Reyer Klaus Wimmers Henk Bovenhuis Just Jensen Genome wide association study of body weight and feed efficiency traits in a commercial broiler chicken population, a re-visitation
description	Abstract Genome wide association study was conducted using a mixed linear model (MLM) approach that accounted for family structure to identify single nucleotide polymorphisms (SNPs) and candidate genes associated with body weight (BW) and feed efficiency (FE) traits in a broiler chicken population. The results of the MLM approach were compared with the results of a general linear model approach that does not take family structure in to account. In total, 11 quantitative trait loci (QTL) and 21 SNPs, were identified to be significantly associated with BW traits and 5 QTL and 5 SNPs were found associated with FE traits using MLM approach. Besides some overlaps between the results of the two GWAS approaches, there are considerable differences in the detected QTL. Even though the genomic inflation factor (λ) values indicate that there is no strong family structure in this population, using models that account for the existing family structure may reduce bias and increase accuracy of the estimated SNP effects in the association analysis. The SNPs and candidate genes identified in this study provide information on the genetic background of BW and FE traits in broiler chickens and might be used as prior information for genomic selection.
format	article
author	Wossenie Mebratie Henry Reyer Klaus Wimmers Henk Bovenhuis Just Jensen
author_facet	Wossenie Mebratie Henry Reyer Klaus Wimmers Henk Bovenhuis Just Jensen
author_sort	Wossenie Mebratie
title	Genome wide association study of body weight and feed efficiency traits in a commercial broiler chicken population, a re-visitation
title_short	Genome wide association study of body weight and feed efficiency traits in a commercial broiler chicken population, a re-visitation
title_full	Genome wide association study of body weight and feed efficiency traits in a commercial broiler chicken population, a re-visitation
title_fullStr	Genome wide association study of body weight and feed efficiency traits in a commercial broiler chicken population, a re-visitation
title_full_unstemmed	Genome wide association study of body weight and feed efficiency traits in a commercial broiler chicken population, a re-visitation
title_sort	genome wide association study of body weight and feed efficiency traits in a commercial broiler chicken population, a re-visitation
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/6758b430489c49328634f4f2339194d6
work_keys_str_mv	AT wosseniemebratie genomewideassociationstudyofbodyweightandfeedefficiencytraitsinacommercialbroilerchickenpopulationarevisitation AT henryreyer genomewideassociationstudyofbodyweightandfeedefficiencytraitsinacommercialbroilerchickenpopulationarevisitation AT klauswimmers genomewideassociationstudyofbodyweightandfeedefficiencytraitsinacommercialbroilerchickenpopulationarevisitation AT henkbovenhuis genomewideassociationstudyofbodyweightandfeedefficiencytraitsinacommercialbroilerchickenpopulationarevisitation AT justjensen genomewideassociationstudyofbodyweightandfeedefficiencytraitsinacommercialbroilerchickenpopulationarevisitation
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Genome wide association study of body weight and feed efficiency traits in a commercial broiler chicken population, a re-visitation

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