Development of antitumor biguanides targeting energy metabolism and stress responses in the tumor microenvironment

Development of antitumor biguanides targeting energy metabolism and stress responses in the tumor microenvironment

Abstract To develop antitumor drugs capable of targeting energy metabolism in the tumor microenvironment, we produced a series of potent new biguanide derivatives via structural modification of the arylbiguanide scaffold. We then conducted biological screening using hypoxia inducible factor (HIF)-1-...

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Autores principales: Takayuki Sakai, Yoshiyuki Matsuo, Kensuke Okuda, Kiichi Hirota, Mieko Tsuji, Tasuku Hirayama, Hideko Nagasawa
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
Materias:
Medicine
R
Science
Q
Acceso en línea:https://doaj.org/article/6759b22745514a5c8c9a25f41acea83c
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