Comparison of the effects of sibling and parental history of type 2 diabetes on metabolic syndrome

Abstract The aim of this study was to investigate the associations between sibling history, parental history and simultaneous sibling and parental history of diabetes, and the presence of the metabolic syndrome (MetS) and its components. Our study comprised 5000 participants from Taiwan Biobank unti...

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Autores principales:	Hsuan Chiu, Mei-Yueh Lee, Pei-Yu Wu, Jiun-Chi Huang, Szu-Chia Chen, Jer-Ming Chang
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/675b2e3df1c54aa4b8cd009d5a247773
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spelling	oai:doaj.org-article:675b2e3df1c54aa4b8cd009d5a2477732021-12-02T11:57:57ZComparison of the effects of sibling and parental history of type 2 diabetes on metabolic syndrome10.1038/s41598-020-79382-z2045-2322https://doaj.org/article/675b2e3df1c54aa4b8cd009d5a2477732020-12-01T00:00:00Zhttps://doi.org/10.1038/s41598-020-79382-zhttps://doaj.org/toc/2045-2322Abstract The aim of this study was to investigate the associations between sibling history, parental history and simultaneous sibling and parental history of diabetes, and the presence of the metabolic syndrome (MetS) and its components. Our study comprised 5000 participants from Taiwan Biobank until April, 2014. The participants were stratified into four groups according to sibling and/or parental family history (FH) of DM. MetS was defined as having 3 of the following 5 abnormalities based on the standard of the NCEP ATP III and modified criteria for Asians. The prevalence of MetS and its traits was estimated and compared among the four familial risk strata. Multivariate logistic regression analysis showed participants with sibling FH of DM [vs. no FH of DM; odds ratio (OR) 1.815; 95% confidence interval (CI) 1.293 to 2.548; p = 0.001], participants with parental FH of DM (vs. no FH of DM; OR 1.771; 95% CI 1.468 to 2.135; p < 0.001), and participants with simultaneous sibling and parental FH of DM (vs. no FH of DM; OR 2.961; 95% CI 2.108 to 4.161; p < 0.001) were significantly associated with MetS. A synergistic effect of sibling FH of DM and parental FH of DM on the association of MetS was also observed. In a nationally representative sample of Taiwan adults, a simultaneous sibling and parental history of diabetes shows a significant, independent association with MetS and its components, except for abdominal obesity. The association highlights the importance of obtaining stratified FH information in clinical practice and may help to identify individuals who should be targeted for screening and early prevention of MetS.Hsuan ChiuMei-Yueh LeePei-Yu WuJiun-Chi HuangSzu-Chia ChenJer-Ming ChangNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 10, Iss 1, Pp 1-8 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Hsuan Chiu Mei-Yueh Lee Pei-Yu Wu Jiun-Chi Huang Szu-Chia Chen Jer-Ming Chang Comparison of the effects of sibling and parental history of type 2 diabetes on metabolic syndrome
description	Abstract The aim of this study was to investigate the associations between sibling history, parental history and simultaneous sibling and parental history of diabetes, and the presence of the metabolic syndrome (MetS) and its components. Our study comprised 5000 participants from Taiwan Biobank until April, 2014. The participants were stratified into four groups according to sibling and/or parental family history (FH) of DM. MetS was defined as having 3 of the following 5 abnormalities based on the standard of the NCEP ATP III and modified criteria for Asians. The prevalence of MetS and its traits was estimated and compared among the four familial risk strata. Multivariate logistic regression analysis showed participants with sibling FH of DM [vs. no FH of DM; odds ratio (OR) 1.815; 95% confidence interval (CI) 1.293 to 2.548; p = 0.001], participants with parental FH of DM (vs. no FH of DM; OR 1.771; 95% CI 1.468 to 2.135; p < 0.001), and participants with simultaneous sibling and parental FH of DM (vs. no FH of DM; OR 2.961; 95% CI 2.108 to 4.161; p < 0.001) were significantly associated with MetS. A synergistic effect of sibling FH of DM and parental FH of DM on the association of MetS was also observed. In a nationally representative sample of Taiwan adults, a simultaneous sibling and parental history of diabetes shows a significant, independent association with MetS and its components, except for abdominal obesity. The association highlights the importance of obtaining stratified FH information in clinical practice and may help to identify individuals who should be targeted for screening and early prevention of MetS.
format	article
author	Hsuan Chiu Mei-Yueh Lee Pei-Yu Wu Jiun-Chi Huang Szu-Chia Chen Jer-Ming Chang
author_facet	Hsuan Chiu Mei-Yueh Lee Pei-Yu Wu Jiun-Chi Huang Szu-Chia Chen Jer-Ming Chang
author_sort	Hsuan Chiu
title	Comparison of the effects of sibling and parental history of type 2 diabetes on metabolic syndrome
title_short	Comparison of the effects of sibling and parental history of type 2 diabetes on metabolic syndrome
title_full	Comparison of the effects of sibling and parental history of type 2 diabetes on metabolic syndrome
title_fullStr	Comparison of the effects of sibling and parental history of type 2 diabetes on metabolic syndrome
title_full_unstemmed	Comparison of the effects of sibling and parental history of type 2 diabetes on metabolic syndrome
title_sort	comparison of the effects of sibling and parental history of type 2 diabetes on metabolic syndrome
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/675b2e3df1c54aa4b8cd009d5a247773
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Comparison of the effects of sibling and parental history of type 2 diabetes on metabolic syndrome

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