Efficacy of ginkgo biloba extract as augmentation of venlafaxine in treating post-stroke depression

Zi-Hong Liang,1 Yan-Bo Jia,2 Mei-Ling Wang,1 Zi-Ru Li,1 Min Li,1 Yong-Li Yun,1 Run-Xiu Zhu1 1Department of Neurology, Inner Mongolia Autonomous Region People’s Hospital, Huhhot, Inner Mongolia, People’s Republic of China; 2Dep...

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Autores principales:	Liang ZH, Jia YB, Wang ML, Li ZR, Li M, Yun YL, Zhu RX
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2019
Materias:	ginkgo biloba extract venlafaxine post-stroke depression PSD Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
Acceso en línea:	https://doaj.org/article/67648f1225da4a1e8fe6f697397820a7
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spelling	oai:doaj.org-article:67648f1225da4a1e8fe6f697397820a72021-12-02T02:16:51ZEfficacy of ginkgo biloba extract as augmentation of venlafaxine in treating post-stroke depression1178-2021https://doaj.org/article/67648f1225da4a1e8fe6f697397820a72019-09-01T00:00:00Zhttps://www.dovepress.com/efficacy-of-ginkgo-biloba-extract-as-augmentation-of-venlafaxine-in-tr-peer-reviewed-article-NDThttps://doaj.org/toc/1178-2021Zi-Hong Liang,1 Yan-Bo Jia,2 Mei-Ling Wang,1 Zi-Ru Li,1 Min Li,1 Yong-Li Yun,1 Run-Xiu Zhu1 1Department of Neurology, Inner Mongolia Autonomous Region People’s Hospital, Huhhot, Inner Mongolia, People’s Republic of China; 2Department of Orthopaedics, The Second Affiliated Hospital of Inner Mongolia Medical University, Huhhot, Inner Mongolia, People’s Republic of ChinaCorrespondence: Run-Xiu ZhuDepartment of Neurology, Inner Mongolia Autonomous Region People’s Hospital, No. 20 Zhaowuda Road, Huhhot, Inner Mongolia010017, People’s Republic of ChinaTel +86 0 471 328 3999Fax +86 0 471 328 3999Email xcinhah-21@foxmail.comBackground: Post-stroke depression (PSD) is one of the most common psychiatric diseases afflicting stroke survivors. This study was conducted to assess the efficacy of ginkgo biloba extract as augmentation of venlafaxine in treating PSD.Methods: The included PSD patients were randomly assigned into the experiment group (receiving ginkgo biloba extract plus venlafaxine) and control group (receiving venlafaxine alone). The treatment was continued for eight weeks. The Hamilton Depression Rating Scale (HDRS) and the Self-rating Depression Scale (SDS) were used to assess the depressive symptoms. The National Institutes of Health Stroke Scale (NIHSS) was used to assess the neurological defect, and the Activities of Daily Living (ADL) was used to assess recovery of abilities of patients after stroke. Meanwhile, the levels of serum 5-hydroxytryptamine (5-HT) and brain-derived neurotrophic factor (BDNF) were measured before and after treatment. The dose of venlafaxine used and adverse events were also recorded.Results: Each group had 40 PSD patients. After treatment, the depressive symptoms, neurological defect and living function were significantly improved in both groups. But the patients receiving ginkgo biloba extract plus venlafaxine had the significantly lower average HDRS score (p=0.0008), SDS score (p<0.00001), NIHSS score (p=0.00001), and higher average ADL score (p=0.0005). Meanwhile, compared to the control group, patients in the experiment group had the significantly higher 5-HT (p<0.00001) level and BDNF level (p<0.00001), needed lower dose of venlafaxine (p=0.007), and experienced fewer adverse events.Conclusion: These results demonstrated that the ginkgo biloba extract was a good augmentation of venlafaxine in treating PSD and should be further investigated.Keywords: ginkgo biloba extract, venlafaxine, post-stroke depression, PSD  Liang ZHJia YBWang MLLi ZRLi MYun YLZhu RXDove Medical Pressarticleginkgo biloba extractvenlafaxinepost-stroke depressionPSDNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571Neurology. Diseases of the nervous systemRC346-429ENNeuropsychiatric Disease and Treatment, Vol Volume 15, Pp 2551-2557 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	ginkgo biloba extract venlafaxine post-stroke depression PSD Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
spellingShingle	ginkgo biloba extract venlafaxine post-stroke depression PSD Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429 Liang ZH Jia YB Wang ML Li ZR Li M Yun YL Zhu RX Efficacy of ginkgo biloba extract as augmentation of venlafaxine in treating post-stroke depression
description	Zi-Hong Liang,1 Yan-Bo Jia,2 Mei-Ling Wang,1 Zi-Ru Li,1 Min Li,1 Yong-Li Yun,1 Run-Xiu Zhu1 1Department of Neurology, Inner Mongolia Autonomous Region People’s Hospital, Huhhot, Inner Mongolia, People’s Republic of China; 2Department of Orthopaedics, The Second Affiliated Hospital of Inner Mongolia Medical University, Huhhot, Inner Mongolia, People’s Republic of ChinaCorrespondence: Run-Xiu ZhuDepartment of Neurology, Inner Mongolia Autonomous Region People’s Hospital, No. 20 Zhaowuda Road, Huhhot, Inner Mongolia010017, People’s Republic of ChinaTel +86 0 471 328 3999Fax +86 0 471 328 3999Email xcinhah-21@foxmail.comBackground: Post-stroke depression (PSD) is one of the most common psychiatric diseases afflicting stroke survivors. This study was conducted to assess the efficacy of ginkgo biloba extract as augmentation of venlafaxine in treating PSD.Methods: The included PSD patients were randomly assigned into the experiment group (receiving ginkgo biloba extract plus venlafaxine) and control group (receiving venlafaxine alone). The treatment was continued for eight weeks. The Hamilton Depression Rating Scale (HDRS) and the Self-rating Depression Scale (SDS) were used to assess the depressive symptoms. The National Institutes of Health Stroke Scale (NIHSS) was used to assess the neurological defect, and the Activities of Daily Living (ADL) was used to assess recovery of abilities of patients after stroke. Meanwhile, the levels of serum 5-hydroxytryptamine (5-HT) and brain-derived neurotrophic factor (BDNF) were measured before and after treatment. The dose of venlafaxine used and adverse events were also recorded.Results: Each group had 40 PSD patients. After treatment, the depressive symptoms, neurological defect and living function were significantly improved in both groups. But the patients receiving ginkgo biloba extract plus venlafaxine had the significantly lower average HDRS score (p=0.0008), SDS score (p<0.00001), NIHSS score (p=0.00001), and higher average ADL score (p=0.0005). Meanwhile, compared to the control group, patients in the experiment group had the significantly higher 5-HT (p<0.00001) level and BDNF level (p<0.00001), needed lower dose of venlafaxine (p=0.007), and experienced fewer adverse events.Conclusion: These results demonstrated that the ginkgo biloba extract was a good augmentation of venlafaxine in treating PSD and should be further investigated.Keywords: ginkgo biloba extract, venlafaxine, post-stroke depression, PSD
format	article
author	Liang ZH Jia YB Wang ML Li ZR Li M Yun YL Zhu RX
author_facet	Liang ZH Jia YB Wang ML Li ZR Li M Yun YL Zhu RX
author_sort	Liang ZH
title	Efficacy of ginkgo biloba extract as augmentation of venlafaxine in treating post-stroke depression
title_short	Efficacy of ginkgo biloba extract as augmentation of venlafaxine in treating post-stroke depression
title_full	Efficacy of ginkgo biloba extract as augmentation of venlafaxine in treating post-stroke depression
title_fullStr	Efficacy of ginkgo biloba extract as augmentation of venlafaxine in treating post-stroke depression
title_full_unstemmed	Efficacy of ginkgo biloba extract as augmentation of venlafaxine in treating post-stroke depression
title_sort	efficacy of ginkgo biloba extract as augmentation of venlafaxine in treating post-stroke depression
publisher	Dove Medical Press
publishDate	2019
url	https://doaj.org/article/67648f1225da4a1e8fe6f697397820a7
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Efficacy of ginkgo biloba extract as augmentation of venlafaxine in treating post-stroke depression

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