The role of Fusobacterium nucleatum in colorectal cancer: from carcinogenesis to clinical management

Colorectal cancer (CRC) is a common malignant tumor that affects people worldwide. Metagenomic analyses have shown an enrichment of Fusobacterium nucleatum (F. nucleatum) in colorectal carcinoma tissue; many studies have indicated that F. nucleatum is closely related to the colorectal carcinogenesis...

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Autores principales:	Chun-Hui Sun, Bin-Bin Li, Bo Wang, Jing Zhao, Xiao-Ying Zhang, Ting-Ting Li, Wen-Bing Li, Di Tang, Miao-Juan Qiu, Xin-Cheng Wang, Cheng-Ming Zhu, Zhi-Rong Qian
Formato:	article
Lenguaje:	EN
Publicado:	KeAi Communications Co., Ltd. 2019
Materias:	Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/67664864bb25488e97f0ef64e0f7163f
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spelling	oai:doaj.org-article:67664864bb25488e97f0ef64e0f7163f2021-12-02T13:22:38ZThe role of Fusobacterium nucleatum in colorectal cancer: from carcinogenesis to clinical management2095-882X10.1016/j.cdtm.2019.09.001https://doaj.org/article/67664864bb25488e97f0ef64e0f7163f2019-09-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S2095882X19300738https://doaj.org/toc/2095-882XColorectal cancer (CRC) is a common malignant tumor that affects people worldwide. Metagenomic analyses have shown an enrichment of Fusobacterium nucleatum (F. nucleatum) in colorectal carcinoma tissue; many studies have indicated that F. nucleatum is closely related to the colorectal carcinogenesis. In this review, we provide the latest information to reveal the related molecular mechanisms. The known virulence factors of F. nucleatum promote adhesion to intestinal epithelial cells via FadA and Fap2. Besides, Fap2 also binds to immune cells causing immunosuppression. Furthermore, F. nucleatum recruits tumor-infiltrating immune cells, thus yielding a pro-inflammatory microenvironment, which promotes colorectal neoplasia progression. F. nucleatum was also found to potentiate CRC development through toll-like receptor 2 (TLR2)/toll-like receptor 4 (TLR4) signaling and microRNA (miRNA)-21 expression. In addition, F. nucleatum increases CRC recurrence along with chemoresistance by mediating a molecular network of miRNA-18a*, miRNA-4802, and autophagy components. Moreover, viable F. nucleatum was detected in mouse xenografts of human primary colorectal adenocarcinomas through successive passages. These findings indicated that an increased number of F. nucleatum in the tissues is a biomarker for the diagnosis and prognosis of CRC, and the underlying molecular mechanism can probably provide a potential intervention treatment strategy for patients with F. nucleatum-associated CRC. Keywords: Fusobacterium nucleatum, Colorectal carcinoma, Carcinogenesis, Immune microenvironment, Intervention therapyChun-Hui SunBin-Bin LiBo WangJing ZhaoXiao-Ying ZhangTing-Ting LiWen-Bing LiDi TangMiao-Juan QiuXin-Cheng WangCheng-Ming ZhuZhi-Rong QianKeAi Communications Co., Ltd.articleMedicine (General)R5-920ENChronic Diseases and Translational Medicine, Vol 5, Iss 3, Pp 178-187 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine (General) R5-920
spellingShingle	Medicine (General) R5-920 Chun-Hui Sun Bin-Bin Li Bo Wang Jing Zhao Xiao-Ying Zhang Ting-Ting Li Wen-Bing Li Di Tang Miao-Juan Qiu Xin-Cheng Wang Cheng-Ming Zhu Zhi-Rong Qian The role of Fusobacterium nucleatum in colorectal cancer: from carcinogenesis to clinical management
description	Colorectal cancer (CRC) is a common malignant tumor that affects people worldwide. Metagenomic analyses have shown an enrichment of Fusobacterium nucleatum (F. nucleatum) in colorectal carcinoma tissue; many studies have indicated that F. nucleatum is closely related to the colorectal carcinogenesis. In this review, we provide the latest information to reveal the related molecular mechanisms. The known virulence factors of F. nucleatum promote adhesion to intestinal epithelial cells via FadA and Fap2. Besides, Fap2 also binds to immune cells causing immunosuppression. Furthermore, F. nucleatum recruits tumor-infiltrating immune cells, thus yielding a pro-inflammatory microenvironment, which promotes colorectal neoplasia progression. F. nucleatum was also found to potentiate CRC development through toll-like receptor 2 (TLR2)/toll-like receptor 4 (TLR4) signaling and microRNA (miRNA)-21 expression. In addition, F. nucleatum increases CRC recurrence along with chemoresistance by mediating a molecular network of miRNA-18a*, miRNA-4802, and autophagy components. Moreover, viable F. nucleatum was detected in mouse xenografts of human primary colorectal adenocarcinomas through successive passages. These findings indicated that an increased number of F. nucleatum in the tissues is a biomarker for the diagnosis and prognosis of CRC, and the underlying molecular mechanism can probably provide a potential intervention treatment strategy for patients with F. nucleatum-associated CRC. Keywords: Fusobacterium nucleatum, Colorectal carcinoma, Carcinogenesis, Immune microenvironment, Intervention therapy
format	article
author	Chun-Hui Sun Bin-Bin Li Bo Wang Jing Zhao Xiao-Ying Zhang Ting-Ting Li Wen-Bing Li Di Tang Miao-Juan Qiu Xin-Cheng Wang Cheng-Ming Zhu Zhi-Rong Qian
author_facet	Chun-Hui Sun Bin-Bin Li Bo Wang Jing Zhao Xiao-Ying Zhang Ting-Ting Li Wen-Bing Li Di Tang Miao-Juan Qiu Xin-Cheng Wang Cheng-Ming Zhu Zhi-Rong Qian
author_sort	Chun-Hui Sun
title	The role of Fusobacterium nucleatum in colorectal cancer: from carcinogenesis to clinical management
title_short	The role of Fusobacterium nucleatum in colorectal cancer: from carcinogenesis to clinical management
title_full	The role of Fusobacterium nucleatum in colorectal cancer: from carcinogenesis to clinical management
title_fullStr	The role of Fusobacterium nucleatum in colorectal cancer: from carcinogenesis to clinical management
title_full_unstemmed	The role of Fusobacterium nucleatum in colorectal cancer: from carcinogenesis to clinical management
title_sort	role of fusobacterium nucleatum in colorectal cancer: from carcinogenesis to clinical management
publisher	KeAi Communications Co., Ltd.
publishDate	2019
url	https://doaj.org/article/67664864bb25488e97f0ef64e0f7163f
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The role of Fusobacterium nucleatum in colorectal cancer: from carcinogenesis to clinical management

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