Cell-type and subcellular compartment-specific APEX2 proximity labeling reveals activity-dependent nuclear proteome dynamics in the striatum

Mapping neuronal proteomes with genetic, subcellular, and temporal specificity is a challenging task. This study uncovers proteome dynamics in two classes of striatal spiny projection neurons in the mouse brain using a genetically targeted APEX2-based proximity labeling approach.

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Autores principales:	V. Dumrongprechachan, R. B. Salisbury, G. Soto, M. Kumar, M. L. MacDonald, Y. Kozorovitskiy
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/67677c39a9624b73b9068c013279223c
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spelling	oai:doaj.org-article:67677c39a9624b73b9068c013279223c2021-12-02T18:50:44ZCell-type and subcellular compartment-specific APEX2 proximity labeling reveals activity-dependent nuclear proteome dynamics in the striatum10.1038/s41467-021-25144-y2041-1723https://doaj.org/article/67677c39a9624b73b9068c013279223c2021-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-25144-yhttps://doaj.org/toc/2041-1723Mapping neuronal proteomes with genetic, subcellular, and temporal specificity is a challenging task. This study uncovers proteome dynamics in two classes of striatal spiny projection neurons in the mouse brain using a genetically targeted APEX2-based proximity labeling approach.V. DumrongprechachanR. B. SalisburyG. SotoM. KumarM. L. MacDonaldY. KozorovitskiyNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-16 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q V. Dumrongprechachan R. B. Salisbury G. Soto M. Kumar M. L. MacDonald Y. Kozorovitskiy Cell-type and subcellular compartment-specific APEX2 proximity labeling reveals activity-dependent nuclear proteome dynamics in the striatum
description	Mapping neuronal proteomes with genetic, subcellular, and temporal specificity is a challenging task. This study uncovers proteome dynamics in two classes of striatal spiny projection neurons in the mouse brain using a genetically targeted APEX2-based proximity labeling approach.
format	article
author	V. Dumrongprechachan R. B. Salisbury G. Soto M. Kumar M. L. MacDonald Y. Kozorovitskiy
author_facet	V. Dumrongprechachan R. B. Salisbury G. Soto M. Kumar M. L. MacDonald Y. Kozorovitskiy
author_sort	V. Dumrongprechachan
title	Cell-type and subcellular compartment-specific APEX2 proximity labeling reveals activity-dependent nuclear proteome dynamics in the striatum
title_short	Cell-type and subcellular compartment-specific APEX2 proximity labeling reveals activity-dependent nuclear proteome dynamics in the striatum
title_full	Cell-type and subcellular compartment-specific APEX2 proximity labeling reveals activity-dependent nuclear proteome dynamics in the striatum
title_fullStr	Cell-type and subcellular compartment-specific APEX2 proximity labeling reveals activity-dependent nuclear proteome dynamics in the striatum
title_full_unstemmed	Cell-type and subcellular compartment-specific APEX2 proximity labeling reveals activity-dependent nuclear proteome dynamics in the striatum
title_sort	cell-type and subcellular compartment-specific apex2 proximity labeling reveals activity-dependent nuclear proteome dynamics in the striatum
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/67677c39a9624b73b9068c013279223c
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Cell-type and subcellular compartment-specific APEX2 proximity labeling reveals activity-dependent nuclear proteome dynamics in the striatum

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