Estimation of Cardiovascular Relative Pressure Using Virtual Work-Energy

Abstract Many cardiovascular diseases lead to local increases in relative pressure, reflecting the higher costs of driving blood flow. The utility of this biomarker for stratifying the severity of disease has thus driven the development of methods to measure these relative pressures. While intravasc...

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Autores principales:	David Marlevi, Bram Ruijsink, Maximilian Balmus, Desmond Dillon-Murphy, Daniel Fovargue, Kuberan Pushparajah, Cristóbal Bertoglio, Massimiliano Colarieti-Tosti, Matilda Larsson, Pablo Lamata, C. Alberto Figueroa, Reza Razavi, David A. Nordsletten
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/676f52cf1ebe445f9e91454e25b4ed5d
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spelling	oai:doaj.org-article:676f52cf1ebe445f9e91454e25b4ed5d2021-12-02T16:08:43ZEstimation of Cardiovascular Relative Pressure Using Virtual Work-Energy10.1038/s41598-018-37714-02045-2322https://doaj.org/article/676f52cf1ebe445f9e91454e25b4ed5d2019-02-01T00:00:00Zhttps://doi.org/10.1038/s41598-018-37714-0https://doaj.org/toc/2045-2322Abstract Many cardiovascular diseases lead to local increases in relative pressure, reflecting the higher costs of driving blood flow. The utility of this biomarker for stratifying the severity of disease has thus driven the development of methods to measure these relative pressures. While intravascular catheterisation remains the most direct measure, its invasiveness limits clinical application in many instances. Non-invasive Doppler ultrasound estimates have partially addressed this gap; however only provide relative pressure estimates for a range of constricted cardiovascular conditions. Here we introduce a non-invasive method that enables arbitrary interrogation of relative pressures throughout an imaged vascular structure, leveraging modern phase contrast magnetic resonance imaging, the virtual work-energy equations, and a virtual field to provide robust and accurate estimates. The versatility and accuracy of the method is verified in a set of complex patient-specific cardiovascular models, where relative pressures into previously inaccessible flow regions are assessed. The method is further validated within a cohort of congenital heart disease patients, providing a novel tool for probing relative pressures in-vivo.David MarleviBram RuijsinkMaximilian BalmusDesmond Dillon-MurphyDaniel FovargueKuberan PushparajahCristóbal BertoglioMassimiliano Colarieti-TostiMatilda LarssonPablo LamataC. Alberto FigueroaReza RazaviDavid A. NordslettenNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 9, Iss 1, Pp 1-16 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q David Marlevi Bram Ruijsink Maximilian Balmus Desmond Dillon-Murphy Daniel Fovargue Kuberan Pushparajah Cristóbal Bertoglio Massimiliano Colarieti-Tosti Matilda Larsson Pablo Lamata C. Alberto Figueroa Reza Razavi David A. Nordsletten Estimation of Cardiovascular Relative Pressure Using Virtual Work-Energy
description	Abstract Many cardiovascular diseases lead to local increases in relative pressure, reflecting the higher costs of driving blood flow. The utility of this biomarker for stratifying the severity of disease has thus driven the development of methods to measure these relative pressures. While intravascular catheterisation remains the most direct measure, its invasiveness limits clinical application in many instances. Non-invasive Doppler ultrasound estimates have partially addressed this gap; however only provide relative pressure estimates for a range of constricted cardiovascular conditions. Here we introduce a non-invasive method that enables arbitrary interrogation of relative pressures throughout an imaged vascular structure, leveraging modern phase contrast magnetic resonance imaging, the virtual work-energy equations, and a virtual field to provide robust and accurate estimates. The versatility and accuracy of the method is verified in a set of complex patient-specific cardiovascular models, where relative pressures into previously inaccessible flow regions are assessed. The method is further validated within a cohort of congenital heart disease patients, providing a novel tool for probing relative pressures in-vivo.
format	article
author	David Marlevi Bram Ruijsink Maximilian Balmus Desmond Dillon-Murphy Daniel Fovargue Kuberan Pushparajah Cristóbal Bertoglio Massimiliano Colarieti-Tosti Matilda Larsson Pablo Lamata C. Alberto Figueroa Reza Razavi David A. Nordsletten
author_facet	David Marlevi Bram Ruijsink Maximilian Balmus Desmond Dillon-Murphy Daniel Fovargue Kuberan Pushparajah Cristóbal Bertoglio Massimiliano Colarieti-Tosti Matilda Larsson Pablo Lamata C. Alberto Figueroa Reza Razavi David A. Nordsletten
author_sort	David Marlevi
title	Estimation of Cardiovascular Relative Pressure Using Virtual Work-Energy
title_short	Estimation of Cardiovascular Relative Pressure Using Virtual Work-Energy
title_full	Estimation of Cardiovascular Relative Pressure Using Virtual Work-Energy
title_fullStr	Estimation of Cardiovascular Relative Pressure Using Virtual Work-Energy
title_full_unstemmed	Estimation of Cardiovascular Relative Pressure Using Virtual Work-Energy
title_sort	estimation of cardiovascular relative pressure using virtual work-energy
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/676f52cf1ebe445f9e91454e25b4ed5d
work_keys_str_mv	AT davidmarlevi estimationofcardiovascularrelativepressureusingvirtualworkenergy AT bramruijsink estimationofcardiovascularrelativepressureusingvirtualworkenergy AT maximilianbalmus estimationofcardiovascularrelativepressureusingvirtualworkenergy AT desmonddillonmurphy estimationofcardiovascularrelativepressureusingvirtualworkenergy AT danielfovargue estimationofcardiovascularrelativepressureusingvirtualworkenergy AT kuberanpushparajah estimationofcardiovascularrelativepressureusingvirtualworkenergy AT cristobalbertoglio estimationofcardiovascularrelativepressureusingvirtualworkenergy AT massimilianocolarietitosti estimationofcardiovascularrelativepressureusingvirtualworkenergy AT matildalarsson estimationofcardiovascularrelativepressureusingvirtualworkenergy AT pablolamata estimationofcardiovascularrelativepressureusingvirtualworkenergy AT calbertofigueroa estimationofcardiovascularrelativepressureusingvirtualworkenergy AT rezarazavi estimationofcardiovascularrelativepressureusingvirtualworkenergy AT davidanordsletten estimationofcardiovascularrelativepressureusingvirtualworkenergy
_version_	1718384474165608448

Estimation of Cardiovascular Relative Pressure Using Virtual Work-Energy

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