Antibody-Based Therapeutic Interventions for Amyotrophic Lateral Sclerosis: A Systematic Literature Review

Amyotrophic Lateral Sclerosis (ALS) is a mid-life onset neurodegenerative disease that manifests its symptomatology with motor impairments and cognitive deficits overlapping with Frontotemporal Lobar Degeneration (FTLD). The etiology of ALS remains elusive, with various mechanisms and cellular targe...

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Autores principales:	Amélie Poulin-Brière, Edris Rezaei, Silvia Pozzi
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	amyotrophic lateral sclerosis antibody-based therapy systematic review knowledge synthesis passive immunization Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571
Acceso en línea:	https://doaj.org/article/677940c8688947009b4e499213572c04
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spelling	oai:doaj.org-article:677940c8688947009b4e499213572c042021-12-01T13:58:55ZAntibody-Based Therapeutic Interventions for Amyotrophic Lateral Sclerosis: A Systematic Literature Review1662-453X10.3389/fnins.2021.790114https://doaj.org/article/677940c8688947009b4e499213572c042021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fnins.2021.790114/fullhttps://doaj.org/toc/1662-453XAmyotrophic Lateral Sclerosis (ALS) is a mid-life onset neurodegenerative disease that manifests its symptomatology with motor impairments and cognitive deficits overlapping with Frontotemporal Lobar Degeneration (FTLD). The etiology of ALS remains elusive, with various mechanisms and cellular targets implicated, and no treatment can reverse or stop the progression of the pathology. Therapeutic interventions based on passive immunization are gaining attention for neurodegenerative diseases, and FDA recently approved the first antibody-based approach for Alzheimer's disease. The present systematic review of the literature aims to highlight the efforts made over the past years at developing antibody-based strategies to cure ALS. Thirty-one original research papers have been selected where the therapeutic efficacy of antibodies were investigated and described in patients and animal models of ALS. Antibody-based interventions analyzed, target both extracellular molecules implicated in the pathology and intracellular pathogenic proteins known to drive the disease, such as SOD1, TDP-43 or C9ORF72 repeats expansions. The potentials and limitations of these therapeutic interventions have been described and discussed in the present review.Amélie Poulin-BrièreEdris RezaeiSilvia PozziSilvia PozziFrontiers Media S.A.articleamyotrophic lateral sclerosisantibody-based therapysystematic reviewknowledge synthesispassive immunizationNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571ENFrontiers in Neuroscience, Vol 15 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	amyotrophic lateral sclerosis antibody-based therapy systematic review knowledge synthesis passive immunization Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571
spellingShingle	amyotrophic lateral sclerosis antibody-based therapy systematic review knowledge synthesis passive immunization Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Amélie Poulin-Brière Edris Rezaei Silvia Pozzi Silvia Pozzi Antibody-Based Therapeutic Interventions for Amyotrophic Lateral Sclerosis: A Systematic Literature Review
description	Amyotrophic Lateral Sclerosis (ALS) is a mid-life onset neurodegenerative disease that manifests its symptomatology with motor impairments and cognitive deficits overlapping with Frontotemporal Lobar Degeneration (FTLD). The etiology of ALS remains elusive, with various mechanisms and cellular targets implicated, and no treatment can reverse or stop the progression of the pathology. Therapeutic interventions based on passive immunization are gaining attention for neurodegenerative diseases, and FDA recently approved the first antibody-based approach for Alzheimer's disease. The present systematic review of the literature aims to highlight the efforts made over the past years at developing antibody-based strategies to cure ALS. Thirty-one original research papers have been selected where the therapeutic efficacy of antibodies were investigated and described in patients and animal models of ALS. Antibody-based interventions analyzed, target both extracellular molecules implicated in the pathology and intracellular pathogenic proteins known to drive the disease, such as SOD1, TDP-43 or C9ORF72 repeats expansions. The potentials and limitations of these therapeutic interventions have been described and discussed in the present review.
format	article
author	Amélie Poulin-Brière Edris Rezaei Silvia Pozzi Silvia Pozzi
author_facet	Amélie Poulin-Brière Edris Rezaei Silvia Pozzi Silvia Pozzi
author_sort	Amélie Poulin-Brière
title	Antibody-Based Therapeutic Interventions for Amyotrophic Lateral Sclerosis: A Systematic Literature Review
title_short	Antibody-Based Therapeutic Interventions for Amyotrophic Lateral Sclerosis: A Systematic Literature Review
title_full	Antibody-Based Therapeutic Interventions for Amyotrophic Lateral Sclerosis: A Systematic Literature Review
title_fullStr	Antibody-Based Therapeutic Interventions for Amyotrophic Lateral Sclerosis: A Systematic Literature Review
title_full_unstemmed	Antibody-Based Therapeutic Interventions for Amyotrophic Lateral Sclerosis: A Systematic Literature Review
title_sort	antibody-based therapeutic interventions for amyotrophic lateral sclerosis: a systematic literature review
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/677940c8688947009b4e499213572c04
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Antibody-Based Therapeutic Interventions for Amyotrophic Lateral Sclerosis: A Systematic Literature Review

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